A5051937026- Asthma and respiratory diseases
- Human Health and Disease
- Vitamin D Research Studies
- Hormonal Regulation and Hypertension
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Stress Responses and Cortisol
- Health and Conflict Studies
- Adipose Tissue and Metabolism
- Systemic Sclerosis and Related Diseases
- Medical History and Research
- Inflammatory Myopathies and Dermatomyositis
- Estrogen and related hormone effects
- Receptor Mechanisms and Signaling
- Iron Metabolism and Disorders
- Diet and metabolism studies
- Respiratory and Cough-Related Research
- Rheumatoid Arthritis Research and Therapies
- Dupuytren's Contracture and Treatments
- Social Media in Health Education
- Radiomics and Machine Learning in Medical Imaging
- Skin Diseases and Diabetes
- Chemical Reactions and Isotopes
- Glycosylation and Glycoproteins Research
- Child and Adolescent Health
Sumy State University
2020-2024
(GR) gene with the body mass index (BMI) of patients bronchial asthma (BA), considering age BA onset. Materials and methods. 553 95 practically healthy persons who previously signed an informed consent to participate in study were examined. Patients divided into two clinical groups according Group I included 282 late-onset (late phenotype), II 271 early onset (early phenotype). The diagnosis severity course established recommendations GINA-2016 subsequent versions. Diagnosis obesity was...
Aim: The study aimed to assess the frequency of Gln27Glu polymorphic variant in β2-AR gene among patients with early and late-onset asthma risks depending on disease phenotype. Materials Methods: Our included a total 553 who consented participate study. Asthma was diagnosed according 2016 GINA recommendations its later versions. approved by Bioethics Committee Medical Institute Sumy State University. analysis for determining genetic polymorphism (designated as rs1042714) conducted through...
Introduction. Previous studies have identified two primary phenotypes of bronchial asthma (BA) associated with obesity: early atopic and late without atopy. These differ in age onset, pathogenic mechanisms development, response to basic treatment. The aim present study was analyze clinical anamnestic data patients BA accompanied obesity, focusing on the onset. Material methods. A cohort 195 obesity were examined. obtained results compared database similar indeces a control group consisted 95...
Introduction. Studies have shown that bronchial asthma (BA) associated with obesity has a more severe course, lower control, frequent cases of low efficacy basic treatment, and exacerbations. Two phenotypes been distinguished in BA-obesity comorbidity based on age onset: early atopic late non-atopic. It is known genetic factors β2-adrenoceptor (AR) genes are important the development both obesity.
 The purpose study aimed to analyze association Gln27Glu polymorphism gene severity course...
РЕЗЮМЕ. Мета дослідження – порівняльна оцінка клінічної та лабораторної ефективності залучення аторвастатину вітаміну D до базисного лікування хворих на БА із ожирінням залежно від віку дебюту.
 Матеріал і методи. Обстежено 195 95 практично здорових осіб. Пацієнтів поділено дві групи дебюту БА: 100 раннім дебютом склали І групу, пізнім ІІ групу. Пацієнти повним контролем початковому етапі ті, які досягли контролю після корекції лікування, були виключені з подальшого дослідження. (n=65)...
The objective of the study was a comparative assessment clinical effectiveness atorvastatin and vitamin D effect on proteolytic activity in obese patients with BA depending age onset. Materials Methods. We examined 195 obesity 95 apparently healthy individuals. were divided into 2 groups regard to onset: Group I included 100 early-onset asthma, II late-onset asthma. Patients complete control at baseline those having achieved after background therapy adjustment excluded from further study....
Вступ. Рання бронхіяльна астма (БА) має генетичні чинники, відмінні від таких у разі пізньої БА, що уможливлює частково пояснити патофізіологічні відмінности між фенотипами БА в дитячому й дорослому віці. Водночас відомо, пов’язані з плейотропними ефектами генів рецепторів до глюкокортикоїдів, β2-адренорецепторів і вітаміну D, лептину, фактора некрозу пухлин (TNF)-α мають важливе значення не лише для ліпшого розуміння виникнення а корелюють тяжкістю її перебігу та прогностичне ефективности...
Introduction. The beginning of the patient-physician relationship often involves delivery bad news. work rheumatologists is unique in that they have to form strong relationships with their patients while delivering Many rheumatology stay doctors for entire lives, which makes it essential create a positive and caring experience them. This depends on physician's professional skills, ability understand patient, engage respectful understandable communication when discussing complicated...
Abstract. It is widely known that both obesity and vitamin D deficiency can lead to increased symptoms of bronchial asthma (ВА) in children adults. Obesity linked higher levels pro-inflammatory mediators lower D. In turn, closely related contribute hyperreactivity, clinical BA, the development pulmonary fibrosis. The study aimed determine patients with considering their body mass index (BMI), age onset, functional characteristics. Research material methods. 553 BA were examined. control...
The study aimed to assess the link between Gln27Glu polymorphism of β2-adrenoceptor (AR) gene and severity asthma course depending on age onset. Methods. 553 patients 95 healthy individuals were examined. Asthma was diagnosed in accordance with GINA recommendations. Patients divided into two groups onset: Group I - 282 late-onset, II 271 early (rs1042714) determined using polymerase chain reaction, analysis restriction fragments. SPSS-17 program used for statistical analysis. Results....
<b>Aim:</b> To analyze the role of Gln27Glu polymorphism β<sub>2</sub>-adrenoreceptor (AR) gene in asthma development <b>Methods:</b> 553 patients and 95 healthy individuals were examined. The β<sub>2</sub>-AR (rs1042714) was determined using polymerase chain reaction. Statistical analysis performed within SPSS-21. <b>Results:</b> According to gene, distribution alleles genotypes corresponded theoretically expected Hardy-Weinberg equilibrium. frequency Gln/Gln,Gln/Glu,Glu/Glu 52.8/37.8/9.4%,...
Early cancer detection through active screening can have a significant impact on mortality rates. Low-Dose CT scan has traditionally been considered an effective method for the early of lung cancer, but its widespread use in patients with COVID-19 allowed us to look at it much more broadly. <b>Purpose:</b> To analyze feasibility performing diagnosis malignant neoplasms by analyzing frequency various locations pneumonia scan. <b>Materials and methods.</b> We analyzed results 6325 aged...
The aim: objective of the study was to analyze frequency Arg16Gly polymorphism in β2 -adrenoceptor (β2 -АR) gene patients with bronchial asthma (BA) and assess association BA risk. Materials methods: We examined 553 95 apparently healthy individuals. -АR (rs1042713) determined using polymerase chain reaction-restriction fragment length analysis. Statistical analysis obtained results performed SPSS–17 program. Results: It established that distribution Arg/Arg, Arg/Gly, Gly/Gly genotypes for...
The aim of our work was to study the indicators systemic inflammation in patients with chronic obstructive pulmonary disease (COPD) anemia (AHD). Materials and methods: included 144 COPD (1 group) without (hemoglobin> 120 g/l for women and> 130 men), 33 (2 ACD (hemoglobin <120 <130 men, soluble transferrin receptors (sTFR) – 8.7 28.1 nmol/l). control group 62 practically healthy people. All were evaluated content ferritin, C-reactive protein (C-RP) hepcidin. Statistical...
It is well known, that anemia of chronic disease (ACD) one the systemic manifestations COPD it leads to a worsening and should be corrected. <b>Aims:</b> Comparative analysis different ACD correction schemes among patients. <b>Materials Methods:</b> 52 patients were included randomized into 3 groups: 1st (n=20) – received 80 mg Fe<sup>2+</sup> 2 times per day os (21 days), 2nd 100 sucrose complex iron hydroxide (III) iv week (4 weeks), 3rd (n=12) human recombinant erythropoietin 3,000 IU...
The study aimed to analyze the frequency of ER22/23EK and Tth111I polymorphisms in glucocorticoid receptor gene (GR) patients with early-onset late-onset asthma assess risk its phenotypes development. <b>Materials Methods:</b> We examined 553 (282 late-onset, group I II – 271 early-onset) 95 apparently healthy individuals. were determined using polymerase chain reaction-restriction fragment length polymorphism analysis. Statistical analysis was performed SPSS–17 program. <b>Results:</b> GG,...
Резюме.Бронхіальна астма (БА), асоційована із ожирінням, представляє окремий фенотип, для якого характерний важчий перебіг захворювання та нижча відповідь на базисну терапію.БА ожиріння визнані як класичні мультифакторіальні захворювання, що виникають в осіб певним генотипом під дією провокуючих факторів зовнішнього середовища.Дослідження генів-кандидатів БА сприятиме поглибленню наших знань і розумінь загальної генетичної основи даних захворювань.Мета.Огляд літератури, містить результати...
Objective — to analyze the control level of obesity‑associated bronchial asthma (BA) with early or late onset depending on Arg16Gly polymorphism b2‑adrenoreceptor gene (b2‑AP). Materials and methods. The study involved 553 BA patients 95 apparently healthy individuals. They were divided into 2 groups: group I included 282 late‑onset (late‑onset phenotype) II 271 early‑onset (early‑onset phenotype). has been approved by Bioethics Committee Medical Institute Sumy State University. in...
The majority of the world population carry gastric pathogen
Aim: The objective of the study was to evaluate frequency ER22/23EK and Tth111I polymorphic variants in glucocorticoid receptor (GR) gene patients with BA assess risk development regard these polymorphisms.Materials Methods: We examined 553 95 apparently healthy individuals. diagnosed according 2016 GINA recommendations its later versions. approved by Bioethics Committee Medical Institute Sumy State University. (rs 6189/6190) (rs10052957) polymorphisms GR were determined using polymerase...