Andy C. W. Lui

ORCID: 0000-0002-9604-7676
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About
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Research Areas
  • Plant biochemistry and biosynthesis
  • Plant Gene Expression Analysis
  • Photosynthetic Processes and Mechanisms
  • Antioxidant Activity and Oxidative Stress
  • Lignin and Wood Chemistry
  • Biochemical and biochemical processes
  • Fermentation and Sensory Analysis
  • Biofuel production and bioconversion
  • Phytochemicals and Antioxidant Activities
  • Plant Molecular Biology Research
  • Microbial Metabolites in Food Biotechnology
  • Plant-Microbe Interactions and Immunity
  • Chemical Synthesis and Analysis
  • Plant Micronutrient Interactions and Effects
  • Plant Disease Resistance and Genetics
  • Cynara cardunculus studies
  • Microbial Natural Products and Biosynthesis
  • Click Chemistry and Applications
  • Aluminum toxicity and tolerance in plants and animals
  • Cocoa and Sweet Potato Agronomy
  • Plant Reproductive Biology
  • Selenium in Biological Systems
  • Plant nutrient uptake and metabolism
  • Aldose Reductase and Taurine

Cornell University
2022-2025

Robert W. Holley Center for Agriculture & Health
2022-2025

University of Hong Kong
2018-2023

Abstract Carotenoids are essential for photosynthesis and photoprotection. Plants must evolve multifaceted regulatory mechanisms to control carotenoid biosynthesis. However, the regulators conserved among plant species remain elusive. Phytoene synthase (PSY) catalyzes highly regulated step of carotenogenesis geranylgeranyl diphosphate (GGPPS) acts as a hub interact with GGPP-utilizing enzymes synthesis specific downstream isoprenoids. Here, we report function Nudix hydrolase 23 (NUDX23),...

10.1093/plcell/koae030 article EN The Plant Cell 2024-01-31

Fungal pathogens are a major constraint to global crop production; hence, plant genes encoding pathogen resistance important tools for combating disease. A few identified date provide partial, durable multiple and the wheat (Triticum aestivum) Lr67 hexose transporter variant (Lr67res) fits into this category. Two amino acids differ between wild-type resistant alleles - G144R V387L. Exome sequence data from 267 barley (Hordeum vulgare) landraces wild accessions was screened neither of Lr67res...

10.1104/pp.18.00945 article EN PLANT PHYSIOLOGY 2018-10-10

Abstract Flavonoids are essential for male fertility in some but not all plant species. In rice (Oryza sativa), the chalcone synthase mutant oschs1 produces flavonoid-depleted pollen and is sterile. The grains viable with normal structure, they display reduced germination rate pollen-tube length. Analysis of oschs1/+ heterozygous lines shows that flavonoid deposition a paternal effect independent haploid genotypes (OsCHS1 or oschs1). To understand which classes flavonoids involved fertility,...

10.1093/jxb/eraa204 article EN Journal of Experimental Botany 2020-04-23

Abstract Lignin is a complex phenylpropanoid polymer deposited in the secondary cell walls of vascular plants. Unlike most gymnosperm and eudicot lignins that are generated via polymerization monolignols, grass additionally incorporate flavonoid tricin as natural lignin monomer. The biosynthesis functions tricin-integrated (tricin-lignin) its effects on utility biomass remain largely unknown. We herein report comparative analysis rice (Oryza sativa) mutants deficient early biosynthetic genes...

10.1093/plphys/kiab606 article EN PLANT PHYSIOLOGY 2021-12-24

Natural products perennially serve as prolific sources of drug leads and chemical probes, fueling the development numerous therapeutics. Despite their scarcity, natural that modulate protein function through covalent interactions with lysine residues hold immense potential to unlock new therapeutic interventions advance our understanding biological processes governed by these modifications. Phloroglucinol meroterpenoids constitute one most expansive classes products, displaying a plethora...

10.1021/jacs.3c10741 article EN Journal of the American Chemical Society 2024-01-17

Flavonoids are ubiquitous in terrestrial plants with important physiological functions. The planta flavonoid profile depends on the activities of different biosynthesis enzymes (Figure 1a). Flavanone 3-hydroxylase (F3H) is a key enzyme channelling carbon flow towards production 3-hydroxylated flavonoids, including flavonols and anthocyanidins. In Poaceae, F3H-encoding genes generally inactive vegetative tissues which accumulate flavone derivatives as predominant metabolites. Meanwhile,...

10.1111/pbi.13397 article EN cc-by Plant Biotechnology Journal 2020-05-06

In rice (Oryza sativa), OsF2H and OsFNSII direct flavanones to independent pathways that form soluble flavone C-glycosides tricin-type metabolites (both lignin-bound), respectively. Production of tricin requires CYP75B4 as a chrysoeriol 5'-hydroxylase. Meanwhile, the close homologue CYP75B3 is canonical flavonoid 3'-hydroxylase (F3'H). However, their precise roles in biosynthesis tricin-lignins cell walls remain unknown. We examined expression vegetative tissues, analyzed extractable...

10.1111/nph.15795 article EN New Phytologist 2019-03-18

Summary Tricin (3′,5′‐dimethoxylated flavone) is a predominant flavonoid amongst monocots but occurs only in isolated and unrelated dicot lineages. Although tricin biosynthesis has been intensively studied monocots, it remained largely elusive tricin‐accumulating dicots. We investigated subgroup of cytochrome P450 (CYP) 75B subfamily B‐ring hydroxylases (FBHs) from two legumes, Medicago truncatula alfalfa ( sativa ), by phylogenetic, molecular, biochemical mutant analyses. Five CYP75B FBHs...

10.1111/nph.16498 article EN New Phytologist 2020-02-21

Chromoplasts are plant organelles with a unique ability to sequester and store massive carotenoids. have been hypothesized enable high levels of carotenoid accumulation due enhanced sequestration or substructure formation. However, the regulators that control component formation in chromoplasts remain unknown. In melon (Cucumis melo) fruit, β-carotene is governed by ORANGE (OR), key regulator for chromoplasts. By using comparative proteomic analysis variety its isogenic line low-β mutant...

10.1093/plphys/kiad312 article EN PLANT PHYSIOLOGY 2023-05-26

Summary Carotenoids are vital photosynthetic pigments for plants. Golden2‐like transcription factors (GLKs) widely recognized as major regulators of Chl biosynthesis and chloroplast development. However, despite GLKs being subjected to intensive investigations, whether directly regulate carotenoid the molecular mechanisms by which transcriptionally activate their target genes remain unclear. Here, we report that in a G‐box binding factor (GBF)‐dependent manner Arabidopsis. Both vitro vivo...

10.1111/nph.20457 article EN New Phytologist 2025-02-14

Abstract O -Methylated stilbenes are prominent nutraceuticals but rarely produced by crops. Here, the inherent ability of two Saccharinae grasses to produce regioselectively -methylated is reported. A stilbene -methyltransferase, SbSOMT, first shown be indispensable for pathogen-inducible pterostilbene (3,5-bis- -methylated) biosynthesis in sorghum ( Sorghum bicolor ). Phylogenetic analysis indicates recruitment genus-specific SOMTs from canonical caffeic acid -methyltransferases (COMTs)...

10.1038/s41467-023-38908-5 article EN cc-by Nature Communications 2023-06-12
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