A5065145098- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Transgenic Plants and Applications
- Bacteriophages and microbial interactions
- SARS-CoV-2 and COVID-19 Research
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- CRISPR and Genetic Engineering
- Herpesvirus Infections and Treatments
- Helicobacter pylori-related gastroenterology studies
- Fibroblast Growth Factor Research
- Corneal Surgery and Treatments
- Poxvirus research and outbreaks
- Wound Healing and Treatments
- Polysaccharides and Plant Cell Walls
- Machine Learning in Bioinformatics
- Sulfur Compounds in Biology
- Postharvest Quality and Shelf Life Management
- Computational Drug Discovery Methods
- Cytomegalovirus and herpesvirus research
- Bacillus and Francisella bacterial research
- Viral Infections and Outbreaks Research
- Glycosylation and Glycoproteins Research
- Genomics and Chromatin Dynamics
Semnan University of Medical Sciences
2023-2024
Iran University of Medical Sciences
2024
Shahrekord University of Medical Sciences
2019-2023
Azarbaijan Shahid Madani University
2018
Monkeypox virus (MPXV) outbreaks have been reported in various countries worldwide; however, there is no specific vaccine against MPXV. In this study, therefore, we employed computational approaches to design a multi-epitope Initially, cytotoxic T lymphocyte (CTL), helper (HTL), linear B lymphocytes (LBL) epitopes were predicted from the cell surface-binding protein and envelope A28 homolog, both of which play essential roles MPXV pathogenesis. All evaluated using key parameters. A total 7...
Abstract Ebola virus (EBOV) is a dangerous zoonotic infectious disease. To date, more than 25 EBOV outbreaks have been documented, the majority of which occurred in Central Africa. The rVSVG-ZEBOV-GP vaccine (ERVEBO), live attenuated vaccine, has approved by US Food and Drug Administration (FDA) to combat EBOV. Because several drawbacks vaccines, multi-epitope vaccines probably appear be safer vaccines. In this work, we employed immunoinformatics tools design against We collected sequences...
Background: SARS-CoV-2 is a life-threatening virus in the world. Scientific evidence indicates that this pathogen will emerge again future. Although current vaccines have pivotal role control of pathogen, emergence new variants has negative impact on their effectiveness. Objective: Therefore, it urgent to consider protective and safe vaccine against all subcoronavirus species based conserved region virus. Multi-epitope peptide (MEV), comprised immune-dominant epitopes, designed by...
The ongoing antibiotic-resistance crisis is becoming a global problem affecting public health. Urgent efforts are required to design novel therapeutics against pathogenic bacterial species. Brucella melitensis an etiological agent of brucellosis, which mostly affects sheep and goats but several cases have also been reported in cattle, water buffalo, yaks dogs. Infected animals represent the major source infection for humans. Development safer effective vaccines brucellosis remains priority...
In July 2022, Langya henipavirus (LayV) was identified in febrile patients China. There is currently no approved vaccine against this virus. Therefore, research aimed to design a multi-epitope LayV using reverse vaccinology. The best epitopes were selected from LayV's fusion protein (F) and glycoprotein (G), designed these epitopes, adjuvant, appropriate linkers. physicochemical properties, antigenicity, allergenicity, toxicity, solubility of the evaluated. vaccine's secondary 3D structures...
Cervical cancer, caused by human papillomavirus (HPV), is the fourth most common type of cancer among women worldwide. While HPV prophylactic vaccines are available, they have no therapeutic effects and do not clear up existing infections. This study aims to design a vaccine against cervical using reverse vaccinology. In this study, E6 E7 oncoproteins from HPV16 were chosen as target antigens for epitope prediction. Cytotoxic T lymphocytes (CTL) helper (HTL) epitopes predicted, best selected...
Cervical cancer is the fourth most common affecting women and caused by human Papillomavirus (HPV) infections that are sexually transmitted. There currently commercially available prophylactic vaccines have been shown to protect vaccinated individuals against HPV infections, however, these no therapeutic effects for those who previously infected with virus. The current study's aim was use immunoinformatics develop a multi-epitope vaccine potential cervical cancer.In this study, T-cell...
The fibroblast growth factor receptor 3 (FGFR3) is warranted as a promising therapeutic target in bladder cancer it described 75% of papillary tumors. Considering this, the present study was conducted to use different approaches computer-aided drug discovery (CADD) identify best binding compounds against active pocket FGFR3. Compared control pyrimidine derivative, identified three lead structures; BDC_24037121, BDC_21200852, and BDC_21206757 with energy value −14.80 kcal/mol, −12.22 −11.67...
Blood-brain barrier (BBB) permeability prediction plays a pivotal role in drug discovery for neurological disorders which is essential the development of central nervous system (CNS) drugs. Compounds having high must be found to synthesize brain drugs treatment different such as Alzheimer's, Parkinson's, and tumors. Developing an accurate mathematical computational model determine exact value possible advancing improving success rate treatment. We developed combined method capable...
Coronary artery disease (CAD) due to atherosclerosis is one of the important reasons for death worldwide. Recent evidence has suggested essential role inflammation in progression atherosclerosis. Interleukin (IL)-37 a critical anti-inflammatory member IL-1 family which regulates inflammatory processes. The aim this study was compare serum levels IL-37 patients with CAD compared control group and its correlation oxidative stress, cholesterol homeostasis, CAD. A total 42 sex-matched age-...
Fanconi anemia (FA) is a genetic disorder that occurs when certain genes responsible for repairing DNA replication and promoting homologous recombination fail to function properly. This leads severe clinical symptoms wide range of cancer-related characteristics. Recent treatment approaches FA involve hematopoietic stem cell transplantation (HSCT), which helps restore the population cells. A survival study using p-values indicated specific hub play significant role in diagnosing predicting...
Abstract Background: Gastric cancer and peptic ulcers can both be caused by Helicobacter pylori ( H. ). So the complexity of such bacterium made it difficult to develop an effective treatment. Thus, a computational approach developing antigenicity, stability, safety in vaccines against this pathogen will aid management related diseases. Methods: This investigation chose two proteins, SabA BabA, as epitope prediction targets. Therefore, study used immunoinformatics platform create subunit...
The severe acute respiratory syndrome coronavirus 2 spike (S) glycoprotein facilitates receptor binding to initiate cell entry that is the critical initial step in infection cycle. Due S glycoprotein's pivotal role, this review, we pointed show potential functional and structural consequences of its variants, which has been related with increased viral load humans SARS-CoV-2 infection.