A5045131182- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Trace Elements in Health
- Nitric Oxide and Endothelin Effects
- Infant Nutrition and Health
- Lipoproteins and Cardiovascular Health
- Iron Metabolism and Disorders
- Medical and Biological Ozone Research
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Antimicrobial Peptides and Activities
- Circadian rhythm and melatonin
- S100 Proteins and Annexins
- RNA Interference and Gene Delivery
- Erythrocyte Function and Pathophysiology
- Vanadium and Halogenation Chemistry
- Lipid metabolism and disorders
- Immune Response and Inflammation
- Atherosclerosis and Cardiovascular Diseases
- Pancreatic function and diabetes
- Streptococcal Infections and Treatments
- Neurological Disorders and Treatments
- Advanced Nanomaterials in Catalysis
University of Warwick
2023-2025
A.E. Arbuzov Institute of Organic and Physical Chemistry
2025
Kazan Federal University
2025
Institute of Experimental Medicine
2014-2023
St Petersburg University
2014-2022
Czech Academy of Sciences, Institute of Experimental Medicine
2007-2022
Petrozavodsk State University
2017
HUN-REN Institute of Experimental Medicine
2016
Academy of Medical Sciences
2008-2015
Russian Academy of Sciences
2008-2015
Recent studies have established that the circadian clock influences onset, progression and therapeutic outcomes in a number of diseases including cancer heart diseases. Therefore, there is need for tools to measure functional state molecular its downstream targets patients. Moreover, multi-dimensional stochastic oscillator are few analysing it as noisy multigene dynamical system. In this paper we consider methodology behind TimeTeller, machine learning tool analyses system aims estimate...
Copper-containing ferroxidase ceruloplasmin (Cp) forms binary and ternary complexes with cationic proteins lactoferrin (Lf) myeloperoxidase (Mpo) during inflammation. We present an X-ray crystal structure of a 2Cp-Mpo complex at 4.7 Å resolution. This allows one to identify major protein–protein interaction areas provides explanation for competitive inhibition Mpo by Cp the activation p-phenylenediamine oxidation Mpo. Small angle scattering was employed construct low-resolution models Cp-Lf...
Here we report on investigation of the role POU domain genes Skin-1a/i (Skn-1a/i/Epoc/Oct-11) and Testes-1 (Tst-1/Oct-6/SCIP) in epidermis where proliferating basal keratinocytes withdraw from cell cycle, migrate suprabasally, terminally differentiate to form a multilayered, stratified epithelium. The expression Skn-1a/i Tst-1 is linked keratinocyte differentiation vivo vitro, whereas ubiquitous factor Oct-1 expressed highly both post-mitotic keratinocytes. Analysis gene-deleted mice reveals...
The mammalian suprachiasmatic nucleus (SCN), situated in the ventral hypothalamus, directs daily cellular and physiological rhythms across body. SCN clockwork is a self-sustaining transcriptional-translational feedback loop (TTFL) that turn co-ordinates expression of clock-controlled genes (CCGs) directing circadian programmes activity. In mouse, transcription factor, ZFHX3 (zinc finger homeobox-3), necessary for development influences behaviour adult. molecular mechanisms by which affects...
The mammalian suprachiasmatic nucleus (SCN), situated in the ventral hypothalamus, directs daily cellular and physiological rhythms across body. SCN clockwork is a self-sustaining transcriptional-translational feedback loop (TTFL) that turn co-ordinates expression of clock-controlled genes (CCGs) directing circadian programmes activity. In mouse, transcription factor, ZFHX3 (zinc finger homeobox-3), necessary for development influences behaviour adult. molecular mechanisms by which affects...
The mammalian suprachiasmatic nucleus (SCN), situated in the ventral hypothalamus, directs daily cellular and physiological rhythms across body. SCN clockwork is a self-sustaining transcriptional-translational feedback loop (TTFL) that turn co-ordinates expression of clock-controlled genes (CCGs) directing circadian programmes activity. In mouse, transcription factor, ZFHX3 (zinc finger homeobox-3), necessary for development influences behaviour adult. molecular mechanisms by which affects...
Lanthanide complexes with organic ligands exhibit unique photophysical properties, including long-lived emission lifetimes, large Stokes shifts, and sharp bands, making them highly attractive for bioanalytical biomedical applications. Incorporating these into nanoparticles can further enhance signal intensity assay sensitivity in both vitro vivo settings. Here, we report the first successful use of desolvation method to synthesize bovine serum albumin (BSA) loaded europium complexes. This...
The mammalian suprachiasmatic nucleus (SCN), situated in the ventral hypothalamus, directs daily cellular and physiological rhythms across body. SCN clockwork is a self-sustaining transcriptional-translational feedback loop (TTFL) that turn coordinates expression of clock-controlled genes (CCGs) directing circadian programmes activity. In mouse, transcription factor, ZFHX3 (zinc finger homeobox-3), necessary for development influences behaviour adult. molecular mechanisms by which affects at...
Ceruloplasmin (CP), the multicopper oxidase of plasma, interacts with myeloperoxidase (MPO), an enzyme leukocytes, and inhibits its peroxidase chlorinating activity. Studies on enzymatic properties shows that CP behaves as a competitive inhibitor impeding binding aromatic substrates to active centre MPO. The contact between MPO probably entails conformational changes close p-phenylenediamine site in CP, which explains observed activation by substrate's oxidation. subjected partial...
Myeloperoxidase (MPO) is a challenging molecular target which, if put under control, may allow regulating the development of inflammatory reactions associated with oxidative/halogenative stress. In this paper, new kinetic method for assaying halogenating activity MPO described. The based on measuring rate iodide-catalyzed oxidation celestine blue B (CB) by oxygen and taurine N-chloramine (bromamine). latter produced in reaction HOCl (HOBr). CB not substrate peroxidase does react hydrogen...
Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) are involved in the development of halogenative stress during inflammation. We previously described a complex between MPO ceruloplasmin (CP). Considering high structural homology EPO, we studied latter's interaction with CP checked whether EPO becomes inhibited CP. Disc-electrophoresis gel filtration showed that form stoichiometry 1:1. Affinity chromatography on CP-agarose (150 mM NaCl, 10 Na-phosphate buffer, pH 7.4) resulted retention...
Familial hypercholesterolemia is a human monogenic disease caused by population-specific mutations in the low density lipoprotein (LDL) receptor gene. Despite thirteen different of LDL gene were reported from Russia prior to 2003, whole spectrum disease-causing alterations this country poorly known and requires further investigation provided current study.Forty-five patients with clinical diagnosis FH tested for apolipoprotein B (apoB) mutation R3500Q restriction fragment length analysis....
Myeloperoxidase (MPO) is a heme-containing enzyme released from activated leukocytes into the extracellular space during inflammation. Its main function production of hypohalous acids that are potent oxidants. MPO can also modulate cell signaling and inflammatory responses independently its enzymatic activity. Because regarded as an important risk factor for cardiovascular diseases associated with increased platelet activity, we studied effects on human functional properties. Laser scanning...