A5025898482- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Polymer Surface Interaction Studies
- Bone Tissue Engineering Materials
- Polymer crystallization and properties
- Polymer Nanocomposites and Properties
- Knee injuries and reconstruction techniques
- Orthopaedic implants and arthroplasty
- Hydrogels: synthesis, properties, applications
- Total Knee Arthroplasty Outcomes
- Advanced Polymer Synthesis and Characterization
- Mechanical Behavior of Composites
- 3D Printing in Biomedical Research
- Polymer composites and self-healing
- Bone health and osteoporosis research
- Surface Modification and Superhydrophobicity
- Polymer Science and Applications
- Adhesion, Friction, and Surface Interactions
- Material Dynamics and Properties
- Advanced Neural Network Applications
- Theoretical and Computational Physics
- 3D Shape Modeling and Analysis
- Block Copolymer Self-Assembly
- Material Properties and Applications
- Pickering emulsions and particle stabilization
Centre des Matériaux
2015-2024
Centre National de la Recherche Scientifique
2010-2024
Université Paris Sciences et Lettres
2017-2024
ESPCI Paris
2016-2024
Laboratoire de Chimie Moléculaire
2017-2023
Chimie Moléculaire, Macromoléculaire, Matériaux
2003-2023
ParisTech
2010-2022
Laboratoire de Chimie Moléculaire et Thioorganique
2022
École Nationale Supérieure des Mines de Paris
2009-2017
New York University
2008-2009
A remarkable self-healing property has been achieved recently with rubbers formed by a supramolecular network of oligomers. Here we explore this through tack-like experiment where two parts rubber are simply brought into contact and then taken apart. These experiments reveal that the self-adhesive strength surfaces is significantly enhanced fracture or other damaging processes. The mechanical energy required to separate were back about one order magnitude larger than for close thermodynamic...
Attaching hydrogels to soft internal tissues is a key the development of number biomedical devices. Nevertheless, wet nature and renders this adhesion most difficult achieve control. Here, we show that transport fluids across hydrogel-tissue interfaces plays central role in adhesion. Using ex vivo peeling experiments on porcine liver, characterized between model hydrogel membranes liver capsule parenchyma. By varying contact time, tissue hydration, swelling ratio membrane, transition two...
Dispersing particles within a semicrystalline polymer can result in remarkable impact strength improvement and opens promising routes toward super-tough materials. Although the technique is extensively employed to modify properties, predicting which dispersions yield toughness remains challenging issue. By comparing characteristic lengths deformation processes involved toughening, we explain why minimum matrix confinement or ligament thickness required induce ductility. Our model was used...
The adsorption of polymers at the surface mesoporous silica nanoparticles (MSNs) has been shown to provide a versatile way create adhesion between hydrogels or biological tissues. Nevertheless, above critical number deposited nanoparticles, thick multilayers accumulate interface and strength decreases as cracks easily propagate weakly cohesive polymer-free nanoparticles. In order suppress this limitation, we prepared spherical aggregates by spray drying during which MSNs are strongly adhered...
Significance This work reports a processing route to fabricate hydrogel films through their rapid and spontaneous growth in aqueous solutions. approach exploits the strong solvent depletion created at surface of polymer substrate swelling solution. By immersing substrates that swell associative solutions, we showed this local suction effect induces gelation films. Experiments simple model captured how kinetics process can be deliberately controlled by handy parameters. Other solutes easily...
Recent studies reveal that suspensions of neutrally buoyant non-brownian particles driven by slow periodic shear can undergo a dynamical phase transition between fluctuating irreversible steady state and an absorbing reversible state. Using computer model, we show such systems exhibit self-organized criticality when finite particle sedimentation velocity v(s) is introduced. Under shear, these evolve, without external intervention, towards the shear-dependent critical concentration phi(c) as...
Since the development of first vascular grafts, fabrication vessel replacements with diameters smaller than 6 mm remains a challenge. The present work aimed to develop PVA (poly (vinyl alcohol))-gelatin hybrids as tubes suitable for replacement very small vessels and evaluate their performance using rat abdominal aorta interposition model. PVA-gelatin hybrid internal external 1.4 1.8 mm, respectively, composed 4 different gelatin ratios were prepared one-step strategy both chemical physical...
In semicrystalline polymers, important toughening is obtained with dispersions of rubber particles. However, adding most often induces a substantial loss in elastic modulus. the present study, we investigate how to avoid such softening by using ABC triblock copolymers low content. A polyamide-12 matrix toughened polystyrene-block-polybutadiene-block-poly(methyl methacrylate) (SBM) containing less than 40 wt % rubber. We compare mechanical properties systems those pure reactive Impact are...
Bone tunnel healing is an important consideration after anterior cruciate ligament (ACL) replacement surgery. Recently, a variety of materials have been proposed for improving this process, including autologous bone tissue, cells, artificial proteins, and calcium salts. Amongst these are phosphates (CaPs), which known their biocompatibility widely commercially available. As with the majority investigated, CaPs shown to advance tissue in animal studies. Mechanical testing shows fixation...
In pathologies of the esophagus such as esophageal atresia, cancers, and caustic injuries, methods for full thickness replacement require sacrifice healthy intra-abdominal organs stomach colon are associated with high morbidity, mortality, poor functional results. To overcome these problems, tissue engineering developed to create a substitute scaffolds cells. The aim this study was develop simple safe decellularization process in order obtain clinical grade extracellular matrix. Following...
Equilibrium morphologies in molten ABC triblock terpolymers are much more difficult to attain than AB diblocks. Here, we show that even the simplest lamellar structures exhibit high sensitivity preparation conditions and strongly trapped structural defects inherent architecture cannot be removed by long annealing. Poly(styrene)-block-poly(butadiene)-block-poly(methyl methacrylate) (SBM) with nearly symmetric composition low molar mass studied combining transmission electron microscopy...
We report the synthesis of networks having adjustable topologies and mechanical properties. Our approach consists photopolymerizing poly(ethylene glycol) diacrylates (PEG-DA) in presence mixtures mono- multifunctional thiols. show that introduction monothiols as non-cross-linking transfer agents provides a simple way to tune topology produce soft extensible networks. In systematic study with model short PEG-DA (Mn = 700 g·mol–1), we explored how gel point network properties, such swelling...
Insufficient bone anchoring is a major limitation of artificial substitutes for connective osteoarticular tissues. The use coatings containing osseoconductive ceramic particles one the actively explored strategies to improve osseointegration and strengthen bone-implant interface general tissue engineering. Our hypothesis that hydroxyapatite (HA) can be coated robustly on specific assemblies PVA hydrogel fibers potential ligament replacements. A simple dip-coating method described produce...
The fixation of hydrogels to biological tissues is a major challenge conditioning the development implants and surgical techniques. Here, coatings procoagulant nanoparticles are devised which use presence blood create adhesion between soft internal organs. Those nanostructured simply adsorbed at hydrogel surfaces can rapidly activate formation an interfacial clot acting as adhesive joint. This concept demonstrated on pig liver capsules with model poly(ethylene-glycol) membranes that...
Adsorption of particles across interfaces has been proposed as a way to create adhesion between hydrogels and biological tissues. Here, we explore how this particle bridging approach can be applied attach soft polymer substrate tissues, using bioresorbable nanostructured hydroxyapatite-bioactive glass microparticles. For this, microparticles aggregated flower-like hydroxyapatite bioactive (HA-BG) were synthesized
Few surfaces can exist at rest in either wrinkled or unwrinkled states and switch reversibly between these states. Here, we report a new approach to creating wrinkling systems using the halogenation of rubber induce local increase glass-transition temperature within thin layer surface. Such are obtained by bromination molded films. By means thermomechanical experiments situ observations, show that microscopic wrinkles produced unstretching stretched film below brominated layer. These surface...