A5042084582- Sarcoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Neurofibromatosis and Schwannoma Cases
- Cancer-related gene regulation
- Glioma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Quinazolinone synthesis and applications
- Chronic Lymphocytic Leukemia Research
- X-ray Spectroscopy and Fluorescence Analysis
- Surgical site infection prevention
- Lung Cancer Treatments and Mutations
- Hematological disorders and diagnostics
- Occupational and environmental lung diseases
- Hepatitis C virus research
- Antibiotic Use and Resistance
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Pancreatic and Hepatic Oncology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Multiple Myeloma Research and Treatments
- Central Venous Catheters and Hemodialysis
- HIV-related health complications and treatments
National Cancer Institute
2021-2024
National Institutes of Health
2021-2024
Center for Cancer Research
2021-2024
University of Illinois Chicago
2023
University of Milan
2023
Federal Reserve
2021
College of Medical Sciences
2013-2015
Zhejiang Center for Disease Control and Prevention
2014
Agenzia Sanitaria e Sociale Regionale
2011-2013
Regione Emilia-Romagna
2013
<b>Objectives</b> To test the hypothesis that a multifaceted, local public campaign could be feasible and influence antibiotic prescribing for outpatients. <b>Design</b> Community level, controlled, non-randomised trial. <b>Setting</b> Provinces of Modena Parma in Emilia-Romagna, northern Italy, November 2011 to February 2012. <b>Population</b> 1 150 000 residents (intervention group) 3 250 provinces same region but where no had been implemented (control group). <b>Interventions</b> Campaign...
Abstract Purpose: Antibodies against insulin-like growth factor (IGF) type 1 receptor have shown meaningful but transient tumor responses in patients with rhabdomyosarcoma (RMS). The SRC family member YES has been to mediate IGF (IGF-1R) antibody acquired resistance, and cotargeting IGF-1R resulted sustained murine RMS models. We conducted a phase I trial of the anti–IGF-1R ganitumab combined dasatinib, multi-kinase inhibitor targeting YES, (NCT03041701). Patients Methods:...
To assess the incidence of nosocomial bloodstream infections (NBSIs) in human immunodeficiency virus (HIV)—infected patients, and to analyze main associated risk factors, we performed a 1-year multicenter prospective study patients with advanced HIV infection who were consecutively admitted 17 Italian infectious diseases wards. As May 1999, total 65 NBSIs (4.7%) occurred 1379 admissions, for an 2.45 per 1000 patient-days. Twenty-nine catheter-related infections, rate 9.6 central venous...
Early detection of neurofibromatosis type 1 (NF1)-associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, enabling early definitive treatment and potentially averting deadly outcomes. In this study, we describe a cell-free DNA (cfDNA) fragmentomic approach that distinguishes nonmalignant, premalignant, malignant forms PNST in the cancer predisposition syndrome, NF1.
Introduction: Acute respiratory infection is a leading cause of morbidity and mortality in under 5 children developing countries. There are various modifiable risk factors associated with Respiratory Tract Infection (ARI). Hence, identification for ARI may be helpful to reduce the burden disease. The aims this study were five hospitalized correlate related morbidity. It was hospital- based prospective study. Materials Methods: Children less than years admitted ward diagnosis enrolled as...
Early detection of neurofibromatosis type 1 (NF1) associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, potentially averting deadly outcomes. Here, we describe a cell-free DNA (cfDNA) fragmentomic approach which distinguishes non-malignant, pre-malignant and malignant forms NF1 PNST. Using plasma samples from novel cohort 101 patients 21 healthy controls, validated that our previous cfDNA copy number alteration (CNA)-based identifies tumor (MPNST) but cannot...
Antibiotic resistance is closely related to antibiotic use and Italy a country with high levels of both antimicrobial resistance. We analysed the trend in community among adults (≥15 years) elderly, period 2003-2009, Emilia-Romagna, Italy, region over 4 000 inhabitants. Data regarding were obtained from regional public health system databases. Between 2003 2009 consumption increased 15.4 18.7 defined daily doses/1000 inhabitants per day (DID) (+21.4%, p <0.0001). The prescription rate was...
<p>Serial samples demonstrate recurrent loci with copy number alterations for each patient.</p>
<p>Fusion-positive RMS enhancer sites; Universal DNAase-hypersensitivity YES1 and IGF1R region sets</p>