Clara Dibenedetto
A5073202915- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Systemic Lupus Erythematosus Research
- Drug-Induced Hepatotoxicity and Protection
- SARS-CoV-2 and COVID-19 Research
- Transplantation: Methods and Outcomes
- Liver Diseases and Immunity
- HIV/AIDS drug development and treatment
- Adrenal Hormones and Disorders
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Impact on Reproduction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Donation and Transplantation
- Cardiac Ischemia and Reperfusion
- Glycosylation and Glycoproteins Research
- Viral-associated cancers and disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Antibiotics Pharmacokinetics and Efficacy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2022-2025
Ospedale Maggiore
2022-2025
Ospedale San Paolo
2019-2021
University of Milan
2011-2021
Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
2019
ASST Melegnano e della Martesana
2016
Centre Hospitalier Universitaire de Poitiers
2011
IRCCS Policlinico San Donato
2011
Abstract Background & Aims Bacterial strains resistant to antibiotics are a serious clinical challenge. We assessed the antibiotic susceptibility of bacteria isolated from infections in patients with cirrhosis by multicentre investigation. Results Three hundred and thirteen culture‐positive (173 community acquired [ CA ] 140 hospital HA ]) were identified 308 patients. Urinary tract infections, spontaneous bacterial peritonitis bacteremias most frequent. Quinolone‐resistant Gram‐negative...
Background: The COVID-19 pandemic highlighted the vulnerability of immunocompromised individuals, including liver transplant recipients (LTRs), who often exhibit reduced vaccine immunogenicity. While initial doses and subsequent boosters improved immune response, LTRs were prioritized for vaccination. Studies have shown increased antibody response after each booster dose. Vaccine hesitancy, defined as delayed or refused vaccination despite availability, poses a public health challenge,...
Background: Coronavirus disease 2019 (COVID-19) vaccination hesitancy is a threat as COVID-19 vaccines have reduced both viral transmission and virus-associated mortality rates, particularly in high-risk subgroups. Solid organ transplant recipients (SOTRs) are vulnerable, the underlying causes of their failure chronic immunosuppression associated with lower immune response to vaccines, an excessive risk death due SARS-CoV-2 infection. We aimed evaluate its reasons population SOTRs. Methods:...
This study assessed humoral and T cell-mediated immune responses to the BNT162b2 vaccine in orthotopic liver transplant (OLT) lung (LUT) recipients who received three doses of from March 2021 at our institution. Serum samples were collected 60 days post-second third dose quantify antibodies against spike region SARS-CoV-2 while whole blood analyze SARS-CoV-2-specific T-cell response using an IFN-γ ELISpot assay. We enrolled 244 OLT 120 LUT recipients. The increased antibody titres (from a...
In routine clinical practice, hepatitis C virus-infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in who discontinued directly acting antiviral (DAA) regimens and assess shortest effective duration DAA able lead SVR12. We retrospectively collected SVR patients, registered NAVIGATORE-Lombardia Network database from January 2015, DAAs before predefined end treatment....
Background: Treatment of chronic Hepatitis C with directly acting antivirals (DAAs) can bring to sustained virologic response (SVR) in approximately 95% patients. Efficacy and safety DAAs aging patients has not been widely analyzed. We aimed determine efficacy DAA-based regimens a cohort elderly real-life setting.Research Design Methods: retrospectively investigated HCV 80 years or older treated three Hepatology Units.Results Expert opinion: During the study period, 170 than received DAAs....
Background Coronary artery disease (CAD) is associated with perioperative liver transplantation (LT) mortality. In absence of a defined risk algorithm, we aimed to test whether stress echocardiography and coronary computed tomography angiography (CCTA) could detect CAD in end-stage (ESLD) patients without previous evidence heart disease.