A5030638022- Fungal Biology and Applications
- Antifungal resistance and susceptibility
- Fungal and yeast genetics research
- Vibrio bacteria research studies
- Fungal Infections and Studies
- Bacterial biofilms and quorum sensing
- Mycotoxins in Agriculture and Food
- Antibiotic Resistance in Bacteria
- Bacterial Genetics and Biotechnology
- Plant-Microbe Interactions and Immunity
- Microbial Natural Products and Biosynthesis
- Probiotics and Fermented Foods
- Polysaccharides and Plant Cell Walls
- Parasite Biology and Host Interactions
- Microbial Metabolic Engineering and Bioproduction
- Plant Reproductive Biology
- Pharmacological Effects of Natural Compounds
- Plant and Biological Electrophysiology Studies
- Chromium effects and bioremediation
- Genomics and Phylogenetic Studies
- Genetics, Aging, and Longevity in Model Organisms
- Enzyme-mediated dye degradation
- Parasites and Host Interactions
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
Instituto de Salud del Estado de México
2020-2025
Universidad Michoacana de San Nicolás de Hidalgo
2014-2023
Secretaria de Salud
2023
Abstract Mucormycosis is a fungal infection caused by Mucorales, with high mortality rate. However, only few virulence factors have been described in these organisms. This study showed that deletion of rfs , which encodes the enzyme for biosynthesis rhizoferrin, siderophore, Mucor lusitanicus led to lower diabetic mice and nematodes. Upregulation correlated increased toxicity cell-free supernatants culture broth (SS) obtained under growing conditions favor oxidative metabolism, such as low...
Mucor circinelloides, a dimorphic opportunistic pathogen, expresses three heterotrimeric G-protein beta subunits (Gpb1, Gpb2 and Gpb3). The Gpb1-encoding gene is up-regulated during mycelial growth compared with that in the spore or yeast stage. gpb1 deletion mutation analysis revealed its relevance for an adequate development transition hyphal under low oxygen concentrations. Infection assays mice indicated phenotype considerably reduced virulence tissue invasiveness mutants (Δgpb1)...
The fungus Mucor circinelloides undergoes yeast-mold dimorphism, a developmental process associated with its capability as human opportunistic pathogen. Dimorphism is strongly influenced by carbon metabolism, and hence the type of metabolism likely affects virulence. We investigated role ethanol in M.
Mucor circinelloides is one of the causal agents mucormycosis, an emerging and high mortality rate fungal infection produced by asexual spores (sporangiospores) fungi that belong to order Mucorales. M. has served as a model genetic system understand virulence mechanism this infection. Although G-protein signaling cascade plays crucial roles in many pathogenic fungi, its Mucorales are yet be elucidated. Previous study found sporangiospore size calcineurin related Mucor, which larger more...
This study analyzed the role of blood serum in enhancing mitochondrial metabolism and virulence Mucorales through rhizoferrin secretion. We observed that spores clinically relevant produced presence exhibited higher a heterologous infection model Galleria mellonella. Cell-free supernatants culture broth obtained from showed increased toxicity against Caenorhabditis elegans, which was linked with enhanced secretion rhizoferrin. Spores Mucoralean species or germinated respiration rates...
Dimorphic species of Mucor, which are cosmopolitan fungi belonging to subphylum Mucoromycotina, metabolically versatile. Some Mucor sources biotechnological products, such as biodiesel from circinelloides and expression heterologous proteins lusitanicus. Furthermore, lusitanicus has been described a model for understanding mucormycosis infections. However, little is known regarding the relationship between other soil inhabitants. In this study, we investigated potential use biocontrol agent...