A5033625024- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Nosocomial Infections in ICU
- Hemodynamic Monitoring and Therapy
- Mesenchymal stem cell research
- Mechanical Circulatory Support Devices
- Pneumonia and Respiratory Infections
- Inflammation biomarkers and pathways
- Heparin-Induced Thrombocytopenia and Thrombosis
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Infrared Thermography in Medicine
- Airway Management and Intubation Techniques
- Neurosurgical Procedures and Complications
- Antimicrobial Resistance in Staphylococcus
- Neuroscience of respiration and sleep
- Laser Applications in Dentistry and Medicine
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Pain Management and Treatment
- Immune cells in cancer
- Tracheal and airway disorders
- Antibiotic Resistance in Bacteria
Institute of Research and Innovation Parc Tauli
2016-2021
Universitat Autònoma de Barcelona
2017-2021
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2016-2020
Corporació Sanitària Parc Taulí
2019-2020
Deleted Institution
2019
Centro de Investigación Biomédica en Red
2018
Indirect indices for measuring impaired ventilation, such as the estimated dead space fraction and ventilatory ratio, have been shown to be independently associated with an increased risk of mortality. This study aimed compare various methods estimation ratio in patients acute respiratory distress syndrome (ARDS) determine their independent values predicting death at day 30. The present is a post hoc analysis prospective observational cohort ICUs two tertiary care hospitals...
In the early stages of acute respiratory distress syndrome (ARDS), pro-inflammatory mediators inhibit natural anticoagulant factors and initiate an increase in procoagulant activity. Previous studies proved beneficial effects heparin pulmonary coagulopathy, which derive from its anti-inflammatory activities, although it is uncertain whether works. Understanding specific effect unfractioned on cell lung populations would be interest to our knowledge about pathways treat ARDS. current study,...
Objectives: Latest trials failed to confirm merits of nebulized amikacin for critically ill patients with nosocomial pneumonia. We studied various and IV antibiotic regimens in a porcine model severe Pseudomonas aeruginosa pneumonia, resistant amikacin, fosfomycin, susceptible meropenem. Design: Prospective randomized animal study. Setting: Animal Research, University Barcelona, Spain. Subjects: Thirty female pigs. Interventions: The animals were receive saline solution (CONTROL); every 6...
Sepsis is a serious, heterogeneous clinical entity produced by severe and systemic host inflammatory response to infection. Methotrexate (MTX) folate-antagonist that induces the generation of adenosine also inhibits JAK/STAT pathway; MTX it widely used as an anti-inflammatory drug control immune system.
Current guidelines recommend vancomycin and linezolid as first-line agents against methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. Telavancin is a potential new therapeutic alternative, specifically in monomicrobial MRSA This study compared the efficacies of telavancin versus porcine model severe In 18 mechanically ventilated pigs (32.11 ± 1.18 kg), 75 ml 106 CFU/ml was administered into each pulmonary lobe. After onset pneumonia, were randomized three groups:...
Acute Respiratory Distress Syndrome (ARDS) is the major cause of respiratory insufficiency in patients and associated with high mortality morbidity. Most sepsis suffer ARDS, characterized by generalized inflammation edema inflammatory cells infiltration. Methotrexate (MTX) an anti-inflammatory drug currently used autoimmune diseases. This reduces lymphocyte proliferation cytokines produced neutrophils macrophages. Our main hypothesis that MTX controls response damage lung. To carry out this...
Alveolar macrophages (AM) play a key role in acute lung injury (ALI). Its depletion study would help us to evaluate the of these cells ALI and whether AM can be potential targets for treatment this syndrome. <b>Aim:</b> Evaluate effect model, through by administration clodronate liposomes. Sprague-Dawley rats (~300g) underwent intratracheal HCl Lipopolysaccharide (LPS)(30μg/g body weight) 2h later. Liposomes PBS or (8µg/g were instilled 9h 33h after administration. Animals sacrificed 72h...
The analysis of biological mediators in plasma septic patients has provided information concerning systemic response the body to process, although molecular markers and pathways that are activated not fully understood. A better understanding cellular will lead raise new effective therapeutic strategies. Plasma from rats was obtained after 6h 24h induced sepsis by a cecal ligation puncture. We isolated type II alveolar cells, macrophages neutrophils lung tissues. Isolated cells were incubated...
<b>Title: Effect of hypercapnia in human primary culture alveolar cells vitro</b> <b>Introduction:</b> Recent insights have emerged regarding the impact on cellular and molecular function. Hypercapnia may potentially beneficial effects patients with ARDS, which are independent benefits from ventilation low tidal volumes. However, other studies suggest that CO2 can act as a signaling molecule via pH mechanisms resulting deleterious lung. <b>Objectives:</b> Determine mechanism action different...
<b>Introduction:</b> In patients with acute respiratory distress syndrome (ARDS) lung-protective ventilation strategies using low tidal volume and airway pressure ameliorated outcome but they lead to hypercapnia. Controversial effects of hypercapnia in ARDS are nowadays being discussed. <b>Aim:</b> Evaluate the effect on inflammatory response, mediators recruitment apoptosis human primary alveolar cells (hATII) injured lipopolysaccharide (LPS). <b>Methods:</b> hATII from pulmonary biopsies...
<b>Background:</b> Recent evidence suggests the beneficial effects of cell therapies and nebulized anticoagulants for acute respiratory distress syndrome (ARDS). <b>Aim:</b> Determine therapeutic benefit a combined therapy (alveolar type II cells (ATII), mesenchymal stem (MSC), supernatant (SN) ATII, SN MSC) with antithrombin in vitro coculture ATII alveolar macrophages injured lipopolysaccharide (LPS). <b>Methods:</b> Cocultured isolated from rat lungs were LPS (10 ng/ml). Two hours after...