A5100331717- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Cardiac pacing and defibrillation studies
- Epilepsy research and treatment
- Advanced Glycation End Products research
- Receptor Mechanisms and Signaling
- Connexins and lens biology
- Lipid metabolism and biosynthesis
- Pancreatic function and diabetes
- Cardiovascular Disease and Adiposity
- Cardiac Arrest and Resuscitation
- Cancer-related gene regulation
- Cardiovascular Syncope and Autonomic Disorders
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Nicotinic Acetylcholine Receptors Study
- Heart Rate Variability and Autonomic Control
- Analytical Chemistry and Sensors
- Chemotherapy-induced cardiotoxicity and mitigation
- Diabetes Treatment and Management
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Electron Spin Resonance Studies
Beijing Anzhen Hospital
2025
Capital Medical University
2025
Nanchang University
2025
Second Affiliated Hospital of Nanchang University
2025
Shanghai Jiao Tong University
2014-2024
Northwest A&F University
2024
Shanghai Chest Hospital
2012-2024
Peking University
2023
Peking University Third Hospital
2023
Xinxiang Medical University
2021
Atrial fibrillation (AF) represents the most common form of sustained cardiac arrhythmia and accounts for substantial morbidity mortality. Mutations in sodium channel α, β1, β2 β3 subunit genes (SCN5A, SCN1B, SCN2B SCN3B) have been associated with AF, which suggests that mutations β4 gene, SCN4B, are also involved pathogenesis AF. To examine this hypothesis, coding exons exon-intron boundaries SCN4B were sequenced 170 unrelated index patients familial The available relatives probands...
The left atrioventricular coupling index (LACI) has emerged as a novel and transformative biomarker in cardiovascular research, addressing long-standing limitations traditional cardiac function assessments. By quantifying the ratio of atrial to ventricular end-diastolic volumes, LACI offers unprecedented prognostic insights into wide range diseases, including fibrillation, heart failure, myocardial infarction, well other conditions such hypertension cardiomyopathies. Recent evidence...
Atrial fibrillation (AF) is the most common form of sustained cardiac arrhythmia in humans and responsible for substantial morbidity mortality worldwide.Emerging evidence indicates that abnormal cardiovascular development involved pathogenesis AF.In this study, coding exons splice sites NKX2-5 gene, which encodes a homeodomain-containing transcription factor essential genesis, were sequenced 146 unrelated patients with lone AF as well available relatives mutation carriers.A total 700...
Atrial fibrillation (AF) is the most common form of cardiac arrhythmia observed in clinical practice and a major contributor to cardiovascular morbidity mortality. Accumulating evidence indicates substantial genetic basis for AF. However, AF genetically heterogeneous hereditary components responsible remain be identified majority patients. The gap junction protein α 5 (GJA5) specifically expressed atrial myocytes associated with coordinated electrical activation atria, providing rationale...
To explore the cardiac electrophysiological characteristics of hypertrophy and its influence on occurrence ventricular tachyarrhythmias.Adult C57BL6 mice were randomly divided into a surgery group control group. Thoracic aortic constriction was performed in group, anatomical ultrasonic evaluations to confirm success model 4 weeks after operation. Using Langendorff method isolated heart perfusion, monophasic action potentials (MAPs) effective refractory period (ERP) at different parts...
The medical usage of Doxorubicin (DOX) as a chemotherapeutic agent is restricted owing to its cardiotoxic properties. This study was designed explore the effect and underlying mechanisms Citronellal (CT) on DOX-related cardiotoxicity in rats. Rats were divided into six groups: control, DOX, CT, Lithium chloride (LiCl) (a Na+/H+exchanger-1 [NHE1] activator), DOX + CT LiCl. To induce cardiotoxicity, cumulative dose 15 mg/kg intraperitoneally injected (150 mg/kg) LiCl (1 given daily by oral...
PB-119, a PEGylated exenatide injection, is once-weekly glucagon-like peptide-1 receptor agonist. In the present study, we aimed to evaluate effects of PB-119 on insulin resistance and beta-cell function in Chinese patients with type 2 diabetes mellitus (T2DM) uncover its antidiabetic characteristics.
Background The regulator of G‐protein signaling 5 (Rgs5), which functions as the G‐protein‐coupled receptor ( GPCR ) including muscarinic receptors, has a potential effect on atrial receptor‐activated I KA ch current. Methods and Results In present study, hearts Rgs5 knockout KO mice had decreased low‐frequency/high‐frequency ratio in spectral measures heart rate variability. Loss provoked dramatically exaggerated bradycardia significantly P <0.05) prolonged sinus nodal recovery time...
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This study sought to the feasibility, efficacy, and safety of using multiscale entropy (MSE) analysis guide catheter ablation for persistent atrial fibrillation (PsAF) predict outcomes.We prospectively enrolled 108 patients undergoing initial PsAF. MSE was calculated based on bipolar intracardiac electrograms (iEGMs) measure dynamical complexity biological signals. The iEGMs data were exported after pulmonary vein isolation (PVI), then in a customed platform, finally re-annotated into CARTO...
<h3>Objectives</h3> Our previous studies showed carvedilol blocked the abrupt termination of an ethanol regimen promoted cardiac sympathetic predominance and life-threatening ventricular arrhythmias in rats. However, mechanisms by which they do are unclear. Cardiac gap junctions provide pathway for intercellular current flow, enabling coordinated action potential propagation contraction. Cell-to-cell coupling is provided predominantly connexin 43 (Cx-43) channels its remodelling supposed to...