A5089885498- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Neuroscience and Neuropharmacology Research
- Neural Networks and Applications
- Advanced Memory and Neural Computing
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Cell Image Analysis Techniques
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Genetics and Neurodevelopmental Disorders
- Parallel Computing and Optimization Techniques
- Innovation in Digital Healthcare Systems
- Neurobiology and Insect Physiology Research
- Internet of Things and Social Network Interactions
- Technology and Data Analysis
- Image Processing Techniques and Applications
- Ferroelectric and Negative Capacitance Devices
- Functional Brain Connectivity Studies
- Cognitive Science and Education Research
- Color perception and design
- Fractal and DNA sequence analysis
- Single-cell and spatial transcriptomics
- Cognitive Functions and Memory
Korea Institute of Civil Engineering and Building Technology
2023-2024
Korea Institute of Brain Science
2015-2023
Korea Advanced Institute of Science and Technology
2015-2023
Korea Institute of Science & Technology Information
2020
Yonsei University
2016
Interneurons control brain arousal states The underlying circuit mechanisms coordinating and motor activity are poorly understood. Liu et al. found that glutamic acid decarboxylase 2 (GAD2)–expressing, but not parvalbumin-expressing, interneurons in a part of the known as substantia nigra promote sleep (see Perspective by Wisden Franks). Parvalbuminergic neurons fire at higher rates high activity, their activation increases movement termination consistent with function suppressing unwanted...
Recent breakthroughs in neuroanatomical tracing methods have helped unravel complicated neural connectivity whole-brain tissue at single-cell resolution. However, most cases, analysis of brain images remains dependent on highly subjective and sample-specific manual processing, preventing precise comparison across sample animals. In the present study, we introduce AMaSiNe, software for automated mapping single neurons standard mouse atlas with annotated regions. AMaSiNe automatically...
Abstract Autism spectrum disorders (ASD) represent neurodevelopmental characterized by social deficits, repetitive behaviors, and various comorbidities, including epilepsy. ANK2 , which encodes a neuronal scaffolding protein, is frequently mutated in ASD, but its vivo functions disease-related mechanisms are largely unknown. Here, we report that mice with Ank2 knockout restricted to cortical hippocampal excitatory neurons (Ank2-cKO mice) show ASD-related behavioral abnormalities juvenile...
Abstract NMDA receptor (NMDAR) and GABA neuronal dysfunctions are observed in animal models of autism spectrum disorders, but how these impair social cognition behavior remains unclear. We report here that NMDARs cortical parvalbumin (Pv)-positive interneurons cooperate with gap junctions to promote high-frequency (>80 Hz) Pv burst firing cognition. Shank2 –/– mice, displaying improved sociability upon NMDAR activation, show impaired representation inhibitory firing. Cortical neurons...
Spike-timing-dependent plasticity (STDP) is considered critical to learning and memory functions in the human brain. Across various types of synapse, STDP observed as different profiles Hebbian anti-Hebbian rules. However, specific roles diverse formation still remain elusive. Here, we show that symmetry rate profile crucial determining character stored memory. Using computer simulations, found an asymmetric generates flexible volatile easily overwritten by newly appended information....
Amygdala circuitry encodes associations between conditioned stimuli and aversive unconditioned also controls fear expression. However, whether how non-threatening information for unpaired (CS-) is discretely processed remains unknown. The expression toward CS- robust immediately after conditioning but then becomes negligible memory consolidation. synaptic plasticity of the neural pathway from lateral to anterior basal amygdala gates CS-, depending upon neuronal PAS domain protein 4...
The serial-position effect in working memory is considered important for studying how a sequence of sensory information can be retained and manipulated simultaneously neural circuits. Here, via precise analysis the primacy recency effects human psychophysical experiments, we propose that stable flexible codings take distinct roles retaining updating memory, their combination induces spontaneously. We found encoding retains to induce effect, while used learning new inputs effect. A model...
Research related to thermal cameras, which are major control measures, is increasing overcome the limitations of closed-circuit television (CCTV) images. Thermal cameras have advantage easily detecting objects at night and being able identify initial signs dangerous situations owing changes in temperature. However, research on from a comprehensive perspective for practical urban insufficient. Accordingly, this study presents camera-based abnormal-situation detection service that can...
Social deficit is a major feature of neuropsychiatric disorders, including autism spectrum schizophrenia, and attention-deficit/hyperactivity disorder, but its neural mechanisms remain unclear. Here, we examined neuronal discharge characteristics in the medial prefrontal cortex (mPFC) IRSp53/Baiap2-mutant mice, which show social deficits, during approach. We found decrease proportion IRSp53-mutant excitatory mPFC neurons encoding information, not that non-social information. In addition,...
Recently, the demand for citizen-sensible service solutions such as traffic, crime prevention, and disasters in smart cities is increasing. In order to provide technology-based city services, local government control centers could be utilized. Accordingly, this paper presented a method selecting center-based dynamic object information utilization model through in-depth interviews with 26 related center operation personnel. A comparative analysis according size of which evaluator belongs was...
The ability to compare quantities of visual objects with two distinct measures, proportion and difference, is observed even in newborn animals. However, how this function originates the brain, before experience, remains unknown. Here, we propose a model which neuronal tuning for quantity comparisons can arise spontaneously completely untrained neural circuits. Using biologically inspired network, find that single units selective proportions differences between emerge randomly initialized...
The objective of this paper is to investigate the dynamic strength characteristics LNG carriers cargo containment system under impact loads experimentally. material properties were experimentally obtained for individual components MARK III insulation system. A series tests was performed using a custom-built drop experiment facility as varying heights and weights object. Crack initiation propagation measured during cyclic dry experiment. quantitative relationship between load crack well cycle...
Abstract Recent breakthroughs in neuroanatomical tracing methods have helped unravel complicated neural connectivity whole brain tissue at a single cellular resolution. However, analysis of images remains dependent on highly subjective manual processing. In the present study, we introduce AMaSiNe, novel software for automated mapping neurons standard mouse atlas. The AMaSiNe automatically calibrates alignment angles each slice to match Allen Reference Atlas (ARA), locates labeled from...
This study conducted a comparative analysis of the factors affecting concentration fine dust before and after COVID-19. Of these, dominant factor was CO, influence between variables increased even In case PM10, wind direction speed decreased, which is thought to be due reduction westerly-based foreign air pollutants following China’s containment policy. Comparative by season showed that temperature humidity higher in winter. spring, decreased with changes westerly summer autumn, when...
To maximize its synergetic effect across the cycle from prevention to response post-crime management, crime requires a balanced combination of spatial urban design and advanced technologies for prediction real-time response. This study derived intelligent Crime Prevention Through Environmental Design (CPTED) services suggested decision model based on fuzzy Technique Order Preference by Similarity Ideal Solution (TOPSIS) implement these in municipal control centers. The analysis results are...
Magnetic resonance imaging (MRI) using an ultra-high magnetic field (7 Tesla) enables detailed and non-invasive studies of the function anatomy human visual cortex, which is brain region responsible for signal processing. However, 7T MRI often suffers from image shading in occipital due to radiofrequency (RF) wave propagation effect. Dedicated cortex coils, on other hand, lack capability visualize whole necessary registration. We propose a novel RF coil structure 2-channel transmit receive...
Abstract A subject-specific process of perceptual decision making is importance to how the brain translates its interpretation sensory information into behavior. In particular, a number studies reported substantial variation across observers’ behavior, which may reflect different profiles evidence accumulated by each individual. However, detailed profile integration has not yet been verified from human behavioral data. To address issue, we precisely measured time course integration, as...
Abstract Bistable perception is characterized by periodic alternation between two different perceptual interpretations, the mechanism of which poorly understood. Herein, we show that decisions in bistable are strongly correlated with slow rhythmic eye motion, frequency varies across individuals. From gaze trajectory measurements during three types tasks, found each subject’s position oscillates slowly(less than 1Hz), and this matches alternation. Notably, motion apparently moves opposite...
A subject-specific process of accumulation information may be responsible for variations in decision time following visual perceptions humans. detailed profile this perceptual making, however, has not yet been verified. Using a coherence-varying motion discrimination task, we precisely measured the kernel subjects. We observed that size (decision time) is consistent within subjects, independent stimulus dynamics, and could accurately predict each subject’s performance. Interestingly,...