A5084530851- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neonatal and Maternal Infections
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Infant Nutrition and Health
- Sepsis Diagnosis and Treatment
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Kawasaki Disease and Coronary Complications
- COVID-19 Impact on Reproduction
- Child Nutrition and Water Access
- Anesthesia and Sedative Agents
- Mechanical Circulatory Support Devices
- Pediatric Pain Management Techniques
- Cardiovascular Conditions and Treatments
- Pregnancy and preeclampsia studies
- Anesthesia and Neurotoxicity Research
Aristotle University of Thessaloniki
2023-2024
Ippokrateio General Hospital of Thessaloniki
2023-2024
Hippocration General Hospital
2023
Background There is limited data on antibiotic treatment in hospitalized neonates low- and middle-income countries (LMICs). We aimed to describe patterns of use, pathogens, clinical outcomes, develop a severity score predicting mortality neonatal sepsis inform future trial design. Methods findings Hospitalized infants <60 days with were enrolled during 2018 2020 by 19 sites 11 (mainly Asia Africa). Prospective daily observational was collected signs, supportive care, treatment,...
Anti-hypotensive treatment, which includes dopamine, dobutamine, epinephrine, norepinephrine, milrinone, vasopressin, terlipressin, levosimendan, and glucocorticoids, is a long-established intervention in neonates with arterial hypotension (AH). However, there are still gaps knowledge issues that need clarification. The main questions challenges neonatologists face relate to the reference ranges of blood pressure presumably healthy relation gestational postnatal age; level potentially...
Background: Multi/extensively drug-resistant bacterial infections have recently increased and new antimicrobial options are needed for difficult-to-treat infections. Ceftazidime/avibactam (CZA) has been approved patients 3 months to 18 years of age, but real-life data on its off-label use in neonates young infants still scarce. Materials: We report demographic, clinical microbiologic as well outcome safety all cases treated with CZA between January 1, 2021 September 30, 2022 a tertiary...
Neonatal sepsis is a significant cause of mortality and morbidity in low- middle-income countries. To deliver high-quality data studies inform future trials, it crucial to understand the challenges encountered when managing global multi-centre research identify solutions that can feasibly be implemented these settings. This paper provides an overview complexities faced by diverse teams different countries regions, together with actions achieve pragmatic study management large observational...
Background: Although ceftazidime/avibactam (CAZ/AVI) has become an important option for treating adults and children, no data or recommendations exist neonates. We report a neonatal sepsis case due to CAZ/AVI-resistant blaKPC-2-harboring Klebsiella pneumoniae carrying blaVEB-25 the use of customized active surveillance program in conjunction with enhanced infection control measures. Methods: The index was extremely premature neonate hospitalized 110 days that had been previously treated...
Respiratory distress syndrome (RDS) is a major respiratory morbidity associated with prematurity. In this case-control study, we prospectively evaluated whether targeted metabolomic analysis (gas chromatography–mass spectrometry) of the gastric fluid obtained from very preterm neonates (&lt; 32 weeks’ gestation) during first hour after birth could predict need for exogenous surfactant treatment RDS. 43 infants RDS necessitating (cases) were compared 30 mild or no (controls) who not...
Antimicrobial resistance has become a significant public health problem globally with multidrug resistant Gram negative (MDR-GN) bacteria being the main representatives. The emergence of these pathogens in neonatal settings threatens well-being vulnerable population given dearth safe and effective therapeutic options. Evidence from studies mainly adults is now available for several novel antimicrobial compounds, such as new &beta;-lactam/&beta;-lactamase inhibitors (e.g....
Prediction of survival in very preterm infants is important terms clinical medicine and parent counseling. In this prospective study involving 96 infants, we evaluated whether metabolomic analysis gastric fluid urine samples obtained soon after birth could predict on days life (DOL) 3 15 as well overall up to hospital discharge. Gas chromatography-mass spectrometry (GC-MS) profiling was used. Uni- multivariate statistical analyses were carried out evaluate significant metabolites their...
Predicting survival in very preterm infants is critical clinical medicine and parent counseling. In this prospective cohort study involving 96 infants, we evaluated whether the metabolomic analysis of gastric fluid urine samples obtained shortly after birth could predict first 3 15 days life (DOL), as well overall up to hospital discharge. Gas chromatography-mass spectrometry (GC-MS) profiling was used. Uni- multivariate statistical analyses were conducted evaluate significant metabolites...
Buckground: Although ceftazidime/avibactam (CAZ/AVI) has become important option for treating adults and children, no recommendations exist neonates. We report a neonatal sepsis case due to CAZ/AVI-resistant KPC-2 producing-Klebsiella pneumoniae carrying blaVEB-25 the use of customized active surveillance program in conjunction infection control measures. Methods: The index was an extremely premature neonate hospitalized 110 days that had been previously treated with multiple antibiotics....
Respiratory distress syndrome (RDS) is a major morbidity of prematurity. In this case–control study, we prospectively evaluated whether untargeted metabolomic analysis (gas chromatography–mass spectrometry) the gastric fluid could predict need for surfactant in very preterm neonates. 43 infants with RDS necessitating (cases) were compared 30 who not treated (controls). Perinatal–neonatal characteristics recorded. Significant differences metabolites (L-proline, L-glycine, L-threonine,...
Pain in early life may seriously impact neonatal outcomes. This study aimed to evaluate whether the perceptions of physicians working intensive care units (NICUs) short-term adverse outcomes associated with pain have changed over a 20-year period. Self-administered questionnaires were distributed 117 and 145 neonatologists, pediatricians, fellows level III NICUs 2000 (T1) 2019 (T2), respectively. The questionnaire consisted four domains, including central nervous, cardiovascular, respiratory...
This was a single center, retrospective cohort study designed to evaluate the association between administration of inotropes hypotensive very low gestational age infants (VLGAI) and prenatal neonatal risk factors. Inpatient medical records were reviewed identify neonates treated with (treated group) control group for comparison. Two hundred twenty two (222) VLGAI (less than 32 weeks' gestation) included in final analysis stratified based on timing treatment 83 (37.4%) 139 (62.6%) groups,...