A5024860869- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- COVID-19 Impact on Reproduction
- Neonatal and Maternal Infections
- Neonatal and fetal brain pathology
- Global Maternal and Child Health
- COVID-19 and healthcare impacts
- Maternal Mental Health During Pregnancy and Postpartum
- Emergency and Acute Care Studies
- Infant Nutrition and Health
- Pneumonia and Respiratory Infections
- Sepsis Diagnosis and Treatment
- Antibiotic Use and Resistance
- Child and Adolescent Health
- Congenital Heart Disease Studies
- Child Nutrition and Water Access
- Lysosomal Storage Disorders Research
- COVID-19 Clinical Research Studies
- Neuroscience of respiration and sleep
- Bacterial Infections and Vaccines
- Cardiovascular Conditions and Treatments
- Fetal and Pediatric Neurological Disorders
- Migration, Health and Trauma
- Disaster Response and Management
- Trypanosoma species research and implications
University of the Witwatersrand
2013-2024
Johannesburg Hospital
2018-2023
Chris Hani Baragwanath Hospital
2022
Background There is limited data on antibiotic treatment in hospitalized neonates low- and middle-income countries (LMICs). We aimed to describe patterns of use, pathogens, clinical outcomes, develop a severity score predicting mortality neonatal sepsis inform future trial design. Methods findings Hospitalized infants <60 days with were enrolled during 2018 2020 by 19 sites 11 (mainly Asia Africa). Prospective daily observational was collected signs, supportive care, treatment,...
Group B Streptococcus (GBS) is a leading cause of neonatal sepsis and meningitis. We aimed to evaluate the burden invasive early-onset (0-6 days life, EOD) late-onset (7-89 days, LOD) GBS disease subsequent neurological sequelae in infants from setting with high prevalence (29.5%) HIV among pregnant women.A case-control study was undertaken at three secondary-tertiary care public hospitals Johannesburg. Invasive cases <3 months age were identified by surveillance laboratories November 2012...
The Bayley Scales of Infant and Toddler Development (III) is a tool developed in Western setting.To evaluate the development group inner city children South Africa with no neonatal risk factors using (III), to determine an appropriate cut-off define developmental delay, establish variation scores done same before after one year age.Cohort follow-up study.74 had at least III assessment mean age 19.4 months (95% CI 18.4 20.4). composite cognitive score was 92.2 89.4 95.0), language 94.8 92.5...
Health protocols need to be guided by current data on survival and benefits of interventions within the local context. Periodic clinical audits are required inform update health care protocols. This study aimed review morbidity mortality in very low birth weight (VLBW) infants 2013 compared with similar from 2006/2007.We performed a retrospective patients' records neonatal computer database for 562 VLBW infants. These neonates weighed between 500 1500 g at birth, were admitted 48 hours after...
Abstract Background Neonatal sepsis is a leading cause of child mortality, and increasing antimicrobial resistance threatens progress towards the Sustainable Development Goals. Evidence to guide antibiotic treatment for in neonates young infants from randomized controlled trials or observational studies low- middle-income countries (LMICs) scarce. We aimed describe patterns use, pathogens outcomes LMIC hospital settings globally inform future clinical on management neonatal sepsis. Methods...
Background. Neonatal hypoxic ischaemic encephalopathy (NHIE) is an important cause of long-term handicap in survivors. There limited information on the burden from NHIE sub-Saharan Africa. Objectives. To determine developmental outcomes survivors South Africa (SA). Methods. In this prospective observational study, 84 infants who had survived (the group) were compared with those 64 unaffected control group). The Bayley Scales Infant Development version III used for assessment outcomes....
Animal-model studies have demonstrated less group B streptococcal (GBS) invasive disease and gastrointestinal colonization after enteral administration of serotype-specific capsular antibodies. There is, however, a paucity information on the association breast milk GBS antibodies risks for in infants. The aim this study was to explore between natural secretory immunoglobulin A (sIgA) occurrence late-onset (LOD) young infants.A matched case-control undertaken infants <3 months age...
Survival of extremely low birth weight (ELBW; less than 1000 g) infants has improved significantly since the 1990s. Consequently, growth monitoring in ELBW gained more relevance.We conducted this study to describe at a tertiary hospital, audit macronutrient intake and explore association prematurity complications with growth. This was retrospective on 92 born Charlotte Maxeke Johannesburg Academic Hospital. The between good (regaining 21 days or subsequent velocity > 15 g/kg/day)...
The study aimed to compare the developmental outcome of very low birth weight infants with a group normal-term controls in tertiary hospital sub-Saharan Africa.A 105 were assessed at mean age 17.6 months (95% CI 16.7 18.6) using Bayley Scales Infant Development, Third Edition, and compared same age.Seven (7%) had delay (a score below 70), none control (p=0.04). Three seven delayed on all three subscales, one whom cerebral palsy. A further 34% 'at risk' 85). There was no difference composite...
Late preterm infants, previously considered low risk, have been identified to be at risk of developmental problems in infancy and early childhood. There is limited information on the outcome these infants middle income countries.Bayley scales infant toddler development, version III, were done a group late Johannesburg, South Africa. The mean composite cognitive, language motor sub-scales compared those obtained from typically developed control infants. Infants "at risk" if subscale score was...
Paediatric intensive care resources are limited in sub-Saharan Africa. The mortality rate a combined Paediatric/Neonatal Intensive Care Unit Johannesburg, South Africa was almost double that dedicated paediatric unit the same country. This study aimed to compare raw with predicted Index of Mortality (version 3), by doing retrospective analysis an existing database. A total 530 patients admitted between 1 January 2015 and 31 December 2017 were included. 27.1% 27.0% (p = 0.971). Cardiac arrest...
IntroductionCandidaemia is a significant problem in neonatal units and associated with high morbidity, including long-term neurodevelopmental impairment survivors, mortality of very low birth weight infants (VLBWI).MethodA retrospective cohort study amongst VLBWI admitted to the unit at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), Johannesburg, South Africa, from 1 January 2013 31 December 2019. All were born hospital or transferred day 28 life blood culture confirmed...
Background The World Health Organization’s “ Coordinated Global Research Roadmap : 2019 Novel Coronavirus ” outlined the need for research that focuses on impact of COVID-19 pregnant women and children. More than one year after first reported case significant knowledge gaps remain, highlighting a coordinated approach. To address this need, Maternal, Newborn Child Working Group (MNCH WG) Clinical Coalition conducted an international survey to identify global priorities in maternal,...
The aim of this study was to explore the prevalence congenital HIV infection neonates at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) between 2015 and 2017, as well compare PCR positive negative neonates.A total number 1443 exposed examined for period out a 5029 admissions (HIV exposure 28.6%) found that rate transmission birth 2.52%. majority infants had low weight were also born prematurely. These results show that, despite introduction extended mother child programme, is high.
Improved survival in extremely low birth weight infants (ELBWI) Sub-Saharan Africa has raised the question whether these survivors have an increased chance of adverse neurodevelopmental outcomes.To describe outcomes ELBWI a neonatal unit South Africa.This was prospective follow-up study. All who survived to discharge between 1 July 2013 and 31 December 2017 were invited attend clinic. Bayley Scales Infant Toddler Development (version III) conducted at 9 12 months 18 24 months.There 723...