A5075911976- Neonatal Respiratory Health Research
- Neonatal and Maternal Infections
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Sepsis Diagnosis and Treatment
- Infant Nutrition and Health
- Cardiovascular Issues in Pregnancy
- Neuroscience of respiration and sleep
- Child Nutrition and Water Access
- Global Maternal and Child Health
- Neonatal Health and Biochemistry
- Birth, Development, and Health
- Antibiotic Use and Resistance
- Infant Development and Preterm Care
- Breastfeeding Practices and Influences
- Infections and bacterial resistance
- Streptococcal Infections and Treatments
- Preterm Birth and Chorioamnionitis
- Cardiac Arrest and Resuscitation
- Cardiac Arrhythmias and Treatments
- Urological Disorders and Treatments
- Cardiac Structural Anomalies and Repair
- Climate Change and Health Impacts
- Blood Coagulation and Thrombosis Mechanisms
Jawaharlal Institute of Post Graduate Medical Education and Research
2016-2025
Creative Commons
2016-2023
Jawaharlal Nehru Medical College
2016-2018
Indira Gandhi Medical College and Research Institute
2016
Pondicherry Institute of Medical Sciences
2008-2014
Alberta Children's Hospital
2010-2012
University of Calgary
2010-2012
Foothills Medical Centre
2012
Background There is limited data on antibiotic treatment in hospitalized neonates low- and middle-income countries (LMICs). We aimed to describe patterns of use, pathogens, clinical outcomes, develop a severity score predicting mortality neonatal sepsis inform future trial design. Methods findings Hospitalized infants <60 days with were enrolled during 2018 2020 by 19 sites 11 (mainly Asia Africa). Prospective daily observational was collected signs, supportive care, treatment,...
Neonatal sepsis epidemiology has been adequately reported in tertiary-care hospitals. However, such data are scarce from district hospitals low-income and middle-income countries. This study aimed to evaluate the incidence of sepsis, pathogen profile, antimicrobial resistance among neonates admitted special newborn care units India. We prospectively enrolled five India between October, 2019, December, 2021. Blood cultures were obtained who met prespecified criteria processed at laboratories...
Objective: To compare the efficacy and safety of oral misoprostol with extra-amniotic saline infusion (EASI) for induction labour in hypertensive disorders pregnancy (HDP) >34 weeks gestation.Methods: This was a randomised, open label, parallel arm trial 1:1 allocation ratio conducted Department Obstetrics Gynaecology, JIPMER, Pondicherry, India. 176 pregnant women gestation HDP admitted Bishop score < 6 were randomised to receive either 25μg three hourly upto 4 doses or EASI (22F...
Objective: The objective of this study was to the effect Holder pasteurization on macronutrients and immunoglobulin profile pooled donor human milk.Methods: This descriptive conducted in a Human Milk Bank tertiary care teaching institute south India. Thirty random paired milk samples (before after pasteurization) were analyzed for (protein, fat, carbohydrates) using infrared spectroscopy. Similarly, (IgA IgG) before quantified ELISA.Results: mean values protein, carbohydrates...
Background: There is a large amount of data on the prevalence and risk factors speech language delay from West, but relatively scanty India. Objectives: The aim this study was to assess in children less than three years old, using Langauge Evaluation Scale Trivandrum (LEST 0-3). Materials Methods: A descriptive, cross sectional conducted under-five clinic our institute, sample 200 children, old. Language assessed 0-3) development other domains Development Screening Chart (TDSC). Home...
Abstract Background Neonatal sepsis is a leading cause of child mortality, and increasing antimicrobial resistance threatens progress towards the Sustainable Development Goals. Evidence to guide antibiotic treatment for in neonates young infants from randomized controlled trials or observational studies low- middle-income countries (LMICs) scarce. We aimed describe patterns use, pathogens outcomes LMIC hospital settings globally inform future clinical on management neonatal sepsis. Methods...
Abstract Objective To estimate the direct causes of mortality among preterm neonates <33 weeks’ gestation by examining three large multicentric, hospital-based datasets in India. Method Three prospective datasets: National Neonatal Perinatal Database (NNPD) India, Delhi Infection Study (DeNIS) cohort, and Goat Lung Surfactant Extract (GLSE)-Plus cohort were analyzed to study death less than 33 admitted participating tertiary care hospitals Results A total 8024 cohorts with 2691 deaths....
Aim To evaluate whether a strategy of oropharyngeal administration colostrum reduces morbidity and mortality in very preterm infants. Methods A total 260 neonates with gestational age 26–31 weeks at birth were randomised between August 2017 2018 to receive 0.2 mL human milk or placebo respectively via the route, beginning within 24 h after birth, continued every 3 until oral feeds initiated. The primary outcome was composite death, late‐onset sepsis (LOS) necrotising enterocolitis (NEC)...
The objective of this study is to the impact a Human Milk Bank (HMB) on neonatal mortality, incidence necrotizing enterocolitis (NEC) and rate exclusive breastfeeding.This pre-post intervention was conducted in tertiary care teaching institute south India. Data regarding NEC, breastfeeding rates were collected for period 6 months before after establishing modern HMB compared.The number deliveries, live births, preterm VLBW neonates during pre- post-HMB periods comparable. Neonatal mortality...
Abstract Clinical trials are essential to test the safety and efficacy of new treatments in any population. The paucity drug especially neonatal population has led widespread use unlicensed or off-label medications, exposing them risks toxicity ineffective treatment. Ethical operational challenges no longer considered valid excuses for not conducting neonates. We recently participated a combined phase-2 phase-3 trial investigating indigenous goat lung surfactant extract (GLSE) treatment...
Aim Prediction of length stay (LOS) among preterm neonates is important for counselling parents and assessing neonatal intensive care unit (NICU) census economic burden. The aim this study to evaluate perinatal postnatal factors that influence LOS in infants (25–33 weeks gestation) admitted participating NICUs Indian National Neonatal Collaborative (INNC). Methods From the INNC database, data which were prospectively entered using uniformed pre‐defined criteria analysed. Results A total 3095...
A 6 year old girl woke up with pain and increasing swelling over the left hand difficulty in breathing. On examination, she had of forearm hand, flaccid quadriparesis was respiratory failure requiring mechanical ventilation. Two clean puncture wounds were identified on thumb. provisional diagnosis snake bite severe envenomation made given anti venom therapy. Over a period about 4 hours her weakness progressed. She became areflexic, developed internal external ophthalmoplegia loss other brain...
Neonatal sepsis is a significant cause of mortality and morbidity in low- middle-income countries. To deliver high-quality data studies inform future trials, it crucial to understand the challenges encountered when managing global multi-centre research identify solutions that can feasibly be implemented these settings. This paper provides an overview complexities faced by diverse teams different countries regions, together with actions achieve pragmatic study management large observational...
We report the case of a male, low birth weight, stillborn fetus 36 weeks gestation with limb body wall complex. An interesting and rare feature noted in propositus was absence left subclavian artery complete upper limb. These findings seem to favor vascular theory pathogenesis this condition.
Objective: To compare the effect of fortified pasteurized donor human milk (PDHM) versus unfortified PDHM on incidence necrotizing enterocolitis (NEC) and immediate outcome among preterm neonates.Methods: This randomized controlled trial (RCT) conducted in a tertiary care teaching hospital, south India included 80 healthy neonates to two groups (Group A B). Neonates Group B were fed with PDHM, respectively. both managed uniformly as per standard NICU protocol. The primary was NEC secondary...