A5101478363- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Bacteriophages and microbial interactions
- Salmonella and Campylobacter epidemiology
- Fish Ecology and Management Studies
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Clostridium difficile and Clostridium perfringens research
- Milk Quality and Mastitis in Dairy Cows
- Vibrio bacteria research studies
- Antibiotic Use and Resistance
- Reproductive Physiology in Livestock
- Enterobacteriaceae and Cronobacter Research
- Hydrology and Watershed Management Studies
- Streptococcal Infections and Treatments
- Ruminant Nutrition and Digestive Physiology
- Microbial Metabolism and Applications
- Neonatal and Maternal Infections
- Metamaterials and Metasurfaces Applications
- Antimicrobial Peptides and Activities
- Veterinary medicine and infectious diseases
- Land Use and Ecosystem Services
- Plant Pathogenic Bacteria Studies
China Agricultural University
2018-2024
Nanjing University of Science and Technology
2024
Ministry of Agriculture and Rural Affairs
2022-2023
Beijing Institute of Water
2018-2019
Jilin Agricultural University
2015
Shandong Provincial Water Resources Research Institute
2010
Background: The rapidly increasing dissemination of carbapenem-resistant Enterobacteriaceae (CRE) in both humans and animals poses a global threat to public health. However, the transmission CRE between has not yet been well studied. Objectives: We investigated prevalence, risk factors, drivers their backyard rural China. Methods: conducted comprehensive sampling strategy 12 villages Shandong, Using household [residents (farm companion animals)] as single surveillance unit, we assessed...
While carbapenem use is prohibited in the poultry production chain and carbapenem-resistant Enterobacteriaceae (CRE) are absent from hatchery farms, New Delhi metallo-β-lactamase-producing CRE contamination of commercial broiler chicken farms (grow-out farms) can occur via living hosts such as flies. However, it not known whether inanimate factors in-house environment play a role persistence on farms. Herein, we monitored one typical house Hebei Province, China, January 2017 to April 2018....
The recent emergence of plasmid-mediated tigecycline resistance genes, tet(X3) and tet(X4), in animals humans China would pose a foreseeable threat to public health. To illustrate this paradigm shift resistance, here, covering the period 2008-2018, we retrospectively analysed national strain collection Escherichia coli (n = 2254), obtained from chickens pigs, six representative provinces China. gene tet(X4) was identified five pig isolates collected 2016 2018 Sichuan (3/15, 2018), Henan...
Tigecycline, the first member of glycylcycline class antibiotic, is often considered one effective antibiotics against multidrug-resistant (MDR) infections. However, emergence and wide distribution two novel plasmid-mediated tigecycline resistance genes, tet (X3) (X4), pose a great threat to clinical use tigecycline.
China is among the world's largest consumers of antibiotics for livestock, and demand meat protein continues to rise. Pig production takes place at a range facilities, including backyard pig farms. The aim this study was describe knowledge, attitudes practices farmers concerning antibiotic use resistance, observe household storage in pigs. We conducted cross-sectional questionnaire survey 271 rural residents with farms 12 villages one town Shandong province. median number pigs per farm 14,...
The wide dissemination of New Delhi metallo-β-lactamase genes (blaNDM) has resulted in the treatment failure most available β-lactam antibiotics, with IncX3-type blaNDM-5-carrying plasmids recognised as having spread worldwide. In China, bacteria carrying these are increasingly being detected from diverse samples, including hospitals, communities, livestock and poultry, environment, suggesting that IncX3 becoming a vital vehicle for blaNDM dissemination. To elucidate fitness cost on...
Abstract Public health interventions to control the recent emergence of plasmid-mediated tigecycline resistance genes rely on a comprehensive understanding its epidemiology and distribution over wide range geographical scales. Here we analysed an Escherichia coli collection isolated from pigs chickens in China 2018, ascertained that tet (X4) gene was not present at high prevalence across China, but highly endemic northwestern China. Genomic analysis (X4)-positive E. demonstrated regional...
Despite carbapenems not being used in animals, carbapenem-resistant Enterobacterales (CRE), particularly New Delhi metallo-β-lactamase-producing CRE (NDM-CRE), are prevalent livestock. Concurrently, the incidence of human infections caused by NDM-CRE is rising, children. Although a positive association between livestock production and at national level was identified, evidence direct transmission NDM originating from to humans remains largely unknown. Here, we conducted cross-sectional study...
It is crucial to discover novel antimicrobial drugs combat resistance. This study investigated the antibacterial properties of halicin (SU3327), an AI-identified anti-diabetic drug, against 13 kinds common clinical pathogens animal origin, including multidrug-resistant strains. Employing minimum inhibitory concentration (MIC) and bactericidal (MBC) assessments, demonstrated a broad-spectrum effect. Time-killing assays revealed its concentration-dependent activity Escherichia coli ATCC 25922...
To characterize the mobile colistin resistance gene mcr-5 in Aeromonas hydrophila from backyard pigs rural areas of China.Pig faecal samples 194 households were directly tested for presence by PCR assay and phenotypic antimicrobial susceptibility profiles mcr-5-positive isolates determined using broth dilution method. The genomic location transferability analysed S1-PFGE with Southern blotting DNA hybridization, natural transformation, respectively. One strain isolated an sample was...
To investigate the presence and molecular characteristics of oxazolidinone resistance genes cfr optrA in staphylococci from household animals rural China.Various samples were collected 12 villages. Staphylococcal isolates showing florfenicol MICs ≥10 mg/L identified screened for and/or optrA. PCR-positive characterized by antimicrobial susceptibility testing, S1 nuclease PFGE Southern blotting. WGS data analysed to identify core-genome phylogenetic profile each isolate as well genetic...
Contezolid is a novel oxazolidinone, which exhibits potent activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and penicillin-resistant Streptococcus pneumoniae (PRSP). In this study, the in vitro of contezolid was compared with linezolid (LZD), tigecycline (TGC), teicoplanin (TEC), vancomycin (VA), daptomycin (DAP), florfenicol (FFC) MRSA VRE strains isolated from China. revealed considerable...
Increasing infections caused by
has emerged as a growing public health concern due to its ability cause various infections and increasing resistance antibiotics. To assess current epidemiology in clinical settings, we conducted survey involving 426 healthy individuals 273 ICU inpatients at provincial hospital China. Our findings revealed high prevalence of
To evaluate rural residents' knowledge, attitudes and practices (KAP) towards antibiotic use in humans pigs, among individuals with without backyard pig farms living Shandong province, China.We conducted a cross-sectional questionnaire study residents 12 villages, directly observed medicines stored households for pigs.In total, 769 participated, including 330 farmers. Respondents had low levels of knowledge about antibiotics. A quarter participants bought one or more antibiotics from...
The objectives of this study were to investigate the prevalence and fluoroquinolone resistant Salmonella isolated from an integrated broiler chicken supply chain their molecular characterization. In total, 73 isolates recovered a in Shanghai. tested for susceptibility 11 antimicrobial agents using broth dilution method characterized pulsed-field gel electrophoresis (PFGE). Then, examined mutations quinolone resistance-determining region (QRDR) gyrA, gyrB, parC, parE, screened...
Abstract Objectives To characterize the relationship of tet(X4)-positive isolates from different hosts and environments. Methods PCR MALDI-TOF MS were used to identify isolates. The MICs 13 antimicrobial agents determined by broth microdilution. Illumina technology was sequence all One isolate randomly selected Escherichia coli ST761 clones for long-read sequencing obtain plasmid sequences. Bioinformatics analysis determine phylogeny 46 E. strains. Results A total 12 isolates, 8 4 Aeromonas...
Introduction To effectively minimise the emergence and dissemination of antibiotic resistant bacteria, a holistic One Health approach is called for. The Sino-Swedish Integrated Multisectoral Partnership for Antibiotic Resistance Containment cross-sectoral integrated project on resistance, conducted in Shandong Province China. This paper outlines overall study protocol project. our knowledge, this first research programme aiming to take true across multiple sectors simultaneously China,...
Abstract Clostridium perfringens is often associated with foodborne diseases, posing significant public health risks. However, genomic investigation of C. isolates from the human population has been lacking. This study aims to fill this knowledge gap by examining characteristics 699 individuals at a provincial hospital in China. We further conducted evolutionary and pan‐genomic analyses, incorporating humans animals worldwide. The results reveal potential regional transregional transmission...
The aim of this study was to investigate the intergeneric transfer vancomycin resistance gene vanA between probiotic enterococci in fermentation progress soybean meal and digestive tract growing pigs. One genotype resistant E. faecium strain, Efm4, one chloramphenicol-resistant faecalis Efs2, were isolated from twenty-nine basis feed material / additive samples. For vitro conjugation, Efm4 Efs2 used as starter ferment meal. vivo thirty pigs randomly assigned five groups (n = 6), treated with...