A5042981913- RNA Research and Splicing
- RNA modifications and cancer
- DNA Repair Mechanisms
- Nuclear Structure and Function
- Amyotrophic Lateral Sclerosis Research
- Heat shock proteins research
- Microtubule and mitosis dynamics
- RNA regulation and disease
- Mitochondrial Function and Pathology
- PARP inhibition in cancer therapy
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- Neurogenetic and Muscular Disorders Research
- Platelet Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Endoplasmic Reticulum Stress and Disease
- Hematopoietic Stem Cell Transplantation
- Neuroendocrine Tumor Research Advances
- Bacteriophages and microbial interactions
- Adrenal Hormones and Disorders
- Autophagy in Disease and Therapy
- 14-3-3 protein interactions
- Machine Learning in Bioinformatics
- Plant and Fungal Species Descriptions
- Global Maternal and Child Health
University of Toronto
2019-2025
University of Michigan–Ann Arbor
2003-2021
Max Planck Institute of Molecular Cell Biology and Genetics
2012-2019
Canada Research Chairs
2019
Phyzen (South Korea)
2018
Max Planck Society
2015
Xi'an Jiaotong University
2011-2012
UNC Lineberger Comprehensive Cancer Center
2010
University of Turin
2010
University of Pittsburgh
2010
Article4 April 2017Open Access Transparent process An aberrant phase transition of stress granules triggered by misfolded protein and prevented chaperone function Daniel Mateju Max Planck Institute Molecular Cell Biology Genetics, Dresden, Germany Search for more papers this author Titus M Franzmann Avinash Patel Andrii Kopach Edgar E Boczek Shovamayee Maharana Hyun O Lee Serena Carra Department Biomedical, Metabolic Neural Sciences, University Modena Reggio Emilia, Modena, Italy Anthony A...
Abstract Cellular processes are influenced by liquid phase separation, but its role in DNA repair is unclear. Here, we show that Saccharomyces cerevisiae , droplets made up of proteins cooperate with different types damage-inducible intranuclear microtubule filaments (DIMs) to promote the clustering damage sites and maintain genome stability. Rad52 at assemble fuse into a centre droplet via action petite DIMs (pti-DIMs). This larger concentrates tubulin projects short aster-like...
Abstract Neurodegeneràve diseases such as amyotrophic lateral sclerosis (ALS) are oten associated with mutàons in proteins that stress granules. Stress granules condensates formed by liquid-liquid phase separàon which, when aberrant, can lead to altered condensàon behaviours and disease phenotypes. Here, we identified lipoamide, a small molecule which specifically prevents cytoplasmic of granule proteins. Thermal proteome profiling showed lipoamide preferentially stabilises intrinsically...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing progressive loss of motor neurons. Mutations in Fused sarcoma (FUS) leading to its cytoplasmic mislocalization cause subset ALS. Under stress, mutant FUS localizes stress granules (SGs)-cytoplasmic condensates composed RNA and various proteins. Aberrant dynamics SGs linked the pathology Here, using neurons (MNs) derived from human induced pluripotent stem cells, we show that, FUS, MN disturbed. Additionally,...
Small Heat Shock Proteins (sHSPs) evolved early in the history of life; they are present archaea, bacteria, and eukaryota. sHSPs belong to superfamily molecular chaperones: components cellular protein quality control machinery thought act as first line defense against conditions that endanger proteome. In plants, protect cells abiotic stresses, providing innovative targets for sustainable agricultural production. humans, (also known HSPBs) associated with development several neurological...
Ipomoea L. is the largest genus within Convolvulaceae and contains 600-700 species. species (morning glories) are economically valuable as horticultural scientifically ecological model plants to investigate mating systems, molecular evolution, both plant-herbivore plant-parasite interactions. Furthermore, dried seeds of I. nil or purpurea used in Korean traditional herbal medicines. In this study, chloroplast (cp) genomes were sequenced from six species, namely, and, for first time, triloba,...
Many membraneless organelles are thought to be biomolecular condensates formed by phase separation of proteins and other biopolymers. Post-translational modifications (PTMs) can impact protein behavior, although for many PTMs this aspect their function is unknown. O-linked β-D-N-acetylglucosaminylation (O-GlcNAcylation) an abundant form intracellular glycosylation whose roles in regulating condensate assembly dynamics have not been delineated. Using vitro approach, we found that...
Linear discriminant analysis is a widely used method for classification. However, the high dimensionality of predictors combined with small sample sizes often results in large classification errors. To address this challenge, it crucial to leverage data from related source models enhance performance target model. We propose problem framework transfer learning. In paper, we present novel learning methods via regularized random-effects linear analysis, where direction estimated as weighted...
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental that affects nearly 3% of children and has strong genetic component. While hundreds ASD risk genes have been identified through sequencing studies, the heterogeneity makes identifying additional using these methods challenging. To predict candidate genes, we developed simple machine learning model, ASiDentify (ASiD), human genomic, RNA- protein-based features. ASiD over 1,300 300 which not previously predicted. made accurate...