A5088168247- Glycosylation and Glycoproteins Research
- Skin and Cellular Biology Research
- Proteoglycans and glycosaminoglycans research
- Cellular Mechanics and Interactions
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- Nanoplatforms for cancer theranostics
- Skin Protection and Aging
- Protease and Inhibitor Mechanisms
- melanin and skin pigmentation
- RNA Interference and Gene Delivery
- Melanoma and MAPK Pathways
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
Charles University
2012-2025
Skåne University Hospital
2021-2022
Lund University
2021-2022
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays critical role in onset progression. Here we show plectin, major cytoskeletal crosslinker protein, crucial mechanical homeostasis mechanosensitive oncogenic signaling drives hepatocarcinogenesis. Our expression analyses revealed elevated plectin levels liver tumors,...
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays critical role in onset progression. Here, we show plectin, major cytoskeletal crosslinker protein, crucial mechanical homeostasis mechanosensitive oncogenic signaling drives hepatocarcinogenesis. Our expression analyses revealed elevated plectin levels liver tumors,...
Treatment of melanoma with a BRAF inhibitor (BRAFi) frequently initiates development BRAFi resistance, leading to increased tumor progression and metastasis. Previously, we showed that combined inhibition elevated WNT5A IL-6 signaling reduced the invasion migration BRAFi-resistant (BRAFi-R) cells. However, use approach per se need for high concentrations achieve this effect indicate an alternative single target. One such target could be myristoylated alanine-rich C-kinase substrate (MARCKS),...
Tumor cells invade and spread via either a mesenchymal or an amoeboid mode of migration. Amoeboid tumor have rounded morphology pronounced RhoA activity. Here, we investigate how WNT5A signaling, promotor in melanoma, relates to Rho GTPase activity We compared melanoma with low (HTB63 cells) high (WM852 expression. HTB63 exhibited had higher but lower invasiveness than WM852 three-dimensional (3D) collagen matrix. next explored the relationships between WNT5A, morphology, invasive behavior....
Abstract The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays critical role in onset progression. Here we show plectin, major cytoskeletal crosslinker protein, crucial mechanical homeostasis mechanosensitive oncogenic signaling drives hepatocarcinogenesis. Our expression analyses revealed elevated plectin levels liver...
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays critical role in onset progression. Here, we show plectin, major cytoskeletal crosslinker protein, crucial mechanical homeostasis mechanosensitive oncogenic signaling drives hepatocarcinogenesis. Our expression analyses revealed elevated plectin levels liver tumors,...
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays critical role in onset progression. Here we show plectin, major cytoskeletal crosslinker protein, crucial mechanical homeostasis mechanosensitive oncogenic signaling drives hepatocarcinogenesis. Our expression analyses revealed elevated plectin levels liver tumors,...
Metastasis is the main cause of death in cancer patients, and spite its significance, it still incompletely understood. In order for to be metastatic, must undergo a sequence events, termed as metastatic cascade. The ability cells migrate invade surrounding tissue critical step metastasis often associated with formation specific cellular structures called invadopodia. Invadopodia are actin-based protrusions tumour or transformed critically involved protease secretion targeting, cytoskeletal...