A5015399212- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Genomics and Diagnostics
- Salivary Gland Tumors Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Radiology practices and education
- Health Systems, Economic Evaluations, Quality of Life
- Tracheal and airway disorders
- Lymphadenopathy Diagnosis and Analysis
- Allergic Rhinitis and Sensitization
- Lung Cancer Research Studies
- Mycobacterium research and diagnosis
- Hedgehog Signaling Pathway Studies
- Ultrasound in Clinical Applications
- Infectious Diseases and Tuberculosis
- Oral and Maxillofacial Pathology
- Cancer-related gene regulation
- Inflammatory Myopathies and Dermatomyositis
- Colorectal and Anal Carcinomas
- Cardiac tumors and thrombi
- Neurofibromatosis and Schwannoma Cases
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
Central University Hospital of Asturias
2016-2025
Universidad De Santander
2025
Universidad de Oviedo
2024-2025
Universidad Panamericana
2024
Universidad de La Frontera
2023
Gobierno del Principado de Asturias
2022
Newark Academy
2021
University of Minnesota Rochester
2021
Texas Oncology
2021
Philadelphia University
2021
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the technique of choice in study mediastinal and hilar lesions; however, it can be affected by insufficiency intact biopsy samples, which might decrease its diagnostic yield for certain conditions, thus requiring re-biopsies or additional procedures such as mediastinoscopy when probability malignancy remains high. Our objectives were to 1) attempt reproduce this same conditions that we performed EBUS-TBNA, i.e....
Transbronchial biopsy using forceps (TBB) is the first diagnostic technique performed on patients with interstitial lung disease (ILD). However, small size of samples and presence artefacts in tissue obtained make yield variable. Our objectives were 1) to attempt reproduce transbronchial cryobiopsy under same conditions which we conventional TBB, that is, bronchoscopy unit without intubating patient fluoroscopy or general anaesthesia; 2) describe method used for its execution; 3) analyse...
After a series of standardized reporting systems in cytopathology, the Sydney system was recently introduced to address need for reproducibility and standardization lymph node cytopathology. Since then, risk malignancy categories has been explored by several studies, but no studies have yet examined interobserver system.The authors assessed on 85 fine-needle aspiration cytology cases reviewed 15 cytopathologists from 12 institutions eight different countries, resulting 1275 diagnoses. In...
Microscopic assessment is essential in the study of mediastinal lymph nodes. Obtaining cytological samples through Endobronchial Ultrasound TransBronchial Needle Aspiration (EBUS-TBNA) has long been considered gold standard procedure. The implementation World Health Organization (WHO) Reporting System for Lymph Node Cytopathology, along with advancement CryoEBUS node technique, enhanced and refined diagnostic accuracy this field. During a two-year period, cases involving parallel performance...
Abstract Introduction It is expected that by the fourth decade of 21st century, chronic obstructive pulmonary disease (COPD) will become third leading cause death worldwide. These data require awareness among treating physicians these patients. Methods A pilot study was conducted from January 2020–December 2022 in a South American health institution which cardiovascular risk estimated using GLOBORISK and ATP-III criteria. Data derived metabolic profile included criteria were collected....
Introduction: Upregulated microtubule-associated serine/threonine kinase like (MASTL), a cell cycle required for progression through mitosis, expression has been associated to poor prognosis. This study is aimed investigate the clinical relevance of MASTL in oral squamous carcinoma (OSCC), and possible mechanistic link with epithelial-mesenchymal transition (EMT). Methods: Immunohistochemical analysis MASTL, E-cadherin, Vimentin, Smad7 was performed paraffin-embedded tissue specimens from...
The growing demand for specialised healthcare often results in prolonged waiting times diagnostic procedures, particularly oncological pathology. Interventional pathology, wherein pathologists perform sample collection and diagnosis, offers a potential solution through same-day services. This study aims to describe the operational framework of One-Stop interventional pathology consultation analyse its outcomes, focusing on response performance patients with superficial nodules. retrospective...
Background The diagnostic accuracy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for the diagnosis lymphoma has a low overall sensitivity. lack tissue architecture obtained by cytological needles decreases and subtyping de novo relapsed mediastinal lymphomas. Objectives This study compares sensitivity between EBUS-TBNA cryobiopsy (EBUS-TMC) both initial recurrence cases, analyzes safety, evaluates number mediastinoscopies that could potentially be avoided...
DICER1 syndrome is a pediatric cancer predisposition condition causing variety of tumor types in children and young adults. In this report we studied family with two relatives presenting neoplastic conditions at childhood. Germ-line mutation screening the complete coding region gene genomic DNA from proband was performed. The presence somatic further alterations driver genes investigated obtained available samples. A nonsense germ-line truncated protein IIIb domain level identified...
<b><i>Introduction:</i></b> The Sydney system proposal for the study and reporting of lymphadenopathy by fine-needle aspiration (FNA) constitutes one first attempts to standardize this procedure. Here, we review its applicability. <b><i>Materials Methods:</i></b> A retrospective in which all ultrasound-guided FNAs (USFNAs) superficial (palpable or not) performed interventional pathologists 2 specialized hospital centers were quantified over...
Abstract Introduction Despite the established role of interventional pathologist, their diagnostic performance is difficult to establish. At least in Spain training pathology residents ultrasound‐guided procedures for specimen collection limited or absent most institutions. We present our teaching experience instruction fine‐needle aspiration (FNA) a tertiary‐level hospital. Materials and Methods The who rotated through unit department application FNA rapid on‐site evaluation (U‐ROSE) was...
Abstract: Endobronchial ultrasound (EBUS)-guided mediastinal cryobiopsy is a novel technique that increases the accuracy of diagnosing most pathologies affect mediastinum. Although EBUS-guided transbronchial needle aspiration (EBUS-TBNA) first choice in diagnosis pathology, offers larger and higher quality biopsy with minimal artifacts no crushing when compared to conventional cytological samples obtained through EBUS-TBNA. It particularly valuable where EBUS-TBNA has diagnostic limitations,...
Multidimensional flow cytometry (MFC) is routinely used for the diagnosis and follow-up of hematolymphoid neoplasms but its contribution to identification non-hematolymphoid malignant tumors limited.The presence cells in clinical samples obtained via minimally invasive methods was ascertained by using a panel monoclonal antibodies previously developed our laboratory comprising mixture antibodies: CD9-PacB/CD45-OC515/CD57-FITC/CD56-PE/CD3-PerCP-Cy5.5/CD117-PE-Cy7/CD326-APC/CD81-APC-C750....
Glioblastoma multiforme (GBS) is a highly malignant glioma that rarely presents as an infratentorial tumor. Multicentric gliomas lesions are widely separated in site and/or time and its incidence has been reported between 0.15 10%. involving supratentorial region even more rare. In most cases, disease seen after surgical manipulation or radiation therapy usually located the cerebellum cervical region.We present rare case of symptomatic multicentric brain, fourth ventricle, well lumbar...
Currently biomarkers play an essential role in diagnosis, treatment, and management of cancer. In non-small cell lung cancer (NSCLC) determination such as ALK, EGFR, ROS1 or PD-L1 is mandatory for adequate treatment decision. The aim this study to determine the clinical economic impact current anaplastic lymphoma kinase testing scenario Spain.
The minimally invasive fine-needle aspiration cytology (FNAC) is the current gold standard for diagnosis of thyroid nodule malignancy. However, correct discrimination follicular neoplasia often requires more diagnostic techniques. lack suitable immunohistochemical markers to distinguish between carcinoma and other types follicular-derived lesions complicates diagnosis, despite most these tumours being surgically resected, only a small number will test positive As such, development new...