A5049470921- Essential Oils and Antimicrobial Activity
- Antibiotic Resistance in Bacteria
- Pneumocystis jirovecii pneumonia detection and treatment
- Biochemical and Molecular Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Ruminant Nutrition and Digestive Physiology
- Insect and Pesticide Research
- Olfactory and Sensory Function Studies
- Crystallography and molecular interactions
- Nicotinic Acetylcholine Receptors Study
- Infections and bacterial resistance
- Enterobacteriaceae and Cronobacter Research
- Phytochemistry and biological activity of medicinal plants
- Phytochemistry and Biological Activities
- Environmental DNA in Biodiversity Studies
- Ethnobotanical and Medicinal Plants Studies
- Cholinesterase and Neurodegenerative Diseases
- Animal health and immunology
- Salmonella and Campylobacter epidemiology
- Nanocomposite Films for Food Packaging
- Effects of Environmental Stressors on Livestock
- Advanced Chemical Sensor Technologies
- Insect Pest Control Strategies
- Agriculture Sustainability and Environmental Impact
University of Parma
2018-2025
Azelaic Acid (AzA) is a 9-carbon atom dicarboxylic acid, with numerous pharmacological uses in dermatology. Its effectiveness papulopustular rosacea and acne vulgaris, among other dermatological disorders such as keratinization hyper-pigmentation, thought to be related its anti-inflammatory antimicrobial properties. It by-product of Pityrosporum fungal mycelia metabolism but also it found different cereals barley, wheat, rye. Diverse topical formulations AzA exist commerce, mainly produced...
Abstract Background Malassezia pachydermatis (MP) is implicated in severe dermatitis and otitis externa (OE) of companion animals recently gained attention for its increasing resistance to azole compounds. For this reason, developing novel therapeutic strategies great interest. In a previous work, we used reference yeast isolates evaluate several compounds bearing acyl/selenoureido moieties primary/secondary sulfonamide groups antifungal activity through organic selenium carbonic anhydrase...
Antibacterial adjuvants are of great significance, since they allow the therapeutic dose conventional antibiotics to be lowered and reduce insurgence antibiotic resistance. Herein, we report that an O-acetylserine sulfhydrylase (OASS) inhibitor can used as a colistin adjuvant treat infections caused by Gram-positive Gram-negative pathogens. A compound binds OASS with nM dissociation constant was tested against six critical pathogens responsible for spreading worldwide, Escherichia coli,...
Klebsiella pneumoniae is the most common species infecting animals and one of causing agents mastitis in cows. The rise antimicrobial resistance K. pneumoniae, particularly strains producing extended-spectrum β-lactamases (ESBLs) and/or carbapenemases, concern worldwide. Recently (Regulation UE No 2022/1255), carbapenems cephalosporins combination with β-lactamase inhibitors have been reserved only to human treatments European Union. aim this study was investigate role cattle as carrier...
The comprehensive identification of secondary metabolites represents a fundamental step for the assessment bioactivities and pharmacological properties traditional herbal drugs. Rumex usambarensis (Dammer) Dammer has been described as multipurpose remedy in different African pharmacopoeias, but its phytochemical profile not properly investigated. Herein we report high throughput metabolomic screening, based on ultra-high performance liquid chromatography-travelling wave ion mobility...
The bacterium Pseudomonas aeruginosa (PA) and the yeast Candida albicans (CA) are pathogens that cohabit mucosa of respiratory tracts animals humans. Their virulence is largely determined by chemical communication driven quorum sensing systems (QS), cross perception their molecules (QSM) can modulate prevalence one microorganism over other. Aiming to investigate whether some protein components dissolved in mucus layering might interfere with cross-communication these, eventually other...
Fungal promoted infections are becoming a severe health global emergency due to drug-resistant phenomena and zoonosis. This work investigated compounds bearing acyl-/selenoureido moieties primary/secondary sulfonamide groups as novel antifungal agents acting through organism-directed selenium toxicity inhibition of the newly emergent therapeutic target, Carbonic Anhydrases (CAs; EC 4.2.1.1). Reported data clearly indicate that seleno-containing scaffolds with respect standard-of-care drugs...
This study is focused on resistance to carbapenems and third-generation cephalosporins in Gram-negative microorganisms isolated from swine, whose transmission humans via pork consumption cannot be excluded. In addition, the common carriage of carbapenem-resistant (CR) bacteria between pigs was evaluated. Sampling involved 300 faecal samples collected slaughtered urine 187 hospitalised patients Parma Province (Italy). MIC testing confirmed meropenem for isolates Pseudomonas aeruginosa...
Antimicrobial resistance (AMR) is an increasing threat to human health and important issue also in the natural environment. For this study, ecopathological approach was applied monitoring of antimicrobial province Parma, Northern Italy. Fourteen sites seventy-four faecal samples from four species wild micromammals (Apodemus sylvaticus, Microtus savii, Mus domesticus Suncus etruscus) were collected. Samples subjected bacteriological examination susceptibility testing. Antibiotics belonging 13...
Snakes are globally considered as pet animals, and millions of ophidians bred in captivity. Pseudomonas aeruginosa is a ubiquitous Gram-negative bacterium that can act an opportunistic pathogen man animals frequently present the oral cloacal microbiota healthy ophidians. It cause severe clinical diseases often shows antibiotic resistance. The aim this study was to evaluate prevalence resistance profiles P. isolated from large population sample captive statistical associations with farming...
Antibacterial adjuvants are of great significance, since they allow one to downscale the therapeutic dose conventional antibiotics and reduce insurgence antibacterial resistance. Herein, we report that O-acetylserine sulfhydrylase (OASS) inhibitors could be used as colistin treat infections caused by critical pathogens spreading worldwide, Escherichia coli, Salmonella enterica serovar Typhimurium, Klebsiella pneumoniae. Starting from a hit compound endowed with nanomolar dissociation...
Leptospirosis in cattle has important economic effects on the infected farms. Moreover, livestock farming is considered a major occupational risk factor for transmission of Leptospira infection to humans. A survey was performed determine overall and within-herd seroprevalence mapping different serovars dairy from farms located some municipalities Colombian department Boyacá. Nine hundred fifty-nine animals, 20 unvaccinated one vaccinated herd, were included study. Anti-Leptospira serum...
Grass-seed inhalation is a common problem in canine patients, particular during summer months, migrating upper and lower respiratory tract. Grass awns can harbor bacteria fungi, causing grass seeds foreign body-related disease (GSFBD). Aim of this study was to investigate the aerobic microbial flora isolated from extracted 41 dogs with GSFBD antibiotic susceptibility bacterial strains. Fifty-four were localized diagnostic imaging tests removed by endoscopy The most frequent localizations...
Essential oils (EOs) and nature identical compounds (NICs) express different antimicrobial activity (AAc) which can be affected by variability in composition, stability over time, the carrier employed for their inclusion feedstuff products animal treatments. The aim of present study was to evaluate time AAc 8 EOs 5 NICs, alone combination with Tween 20, on four major bacterial livestock pathogens (E. coli, S. Typhimurium, aureus MRSA). For this purpose, minimal inhibitory concentration (MIC)...
Many bacteria and actinomycetales use L-cysteine biosynthesis to increase their tolerance antibacterial treatment establish a long-lasting infection. In turn, this might lead the onset of antimicrobial resistance that currently represents one most menacing threats public health worldwide. The biosynthetic machinery required synthesise is absent in mammals; therefore, its exploitation as drug target particularly promising. article, we report series inhibitors Salmonella thyphimurium serine...
Infections caused by the opportunistic yeast Candida albicans are one of major life threats for hospitalized and immunocompromised patients, as a result antibiotic long-term antifungal treatment abuse. Odorant binding proteins can be considered interesting candidates to develop systems able reduce proliferation virulence this yeast, because their intrinsic antimicrobial properties complexation capabilities toward farnesol, quorum sensing molecule albicans. In present study, hybrid system...
The aim of this trial was to investigate the effects a blend monoglycerides short- and medium-chain fatty acids (SMCFA) on health status growth preweaned male calves from 16 72 days age. in vivo study conducted as complete randomised block design. Twenty Italian Holstein received starter administered ad libitum 6 L milk replacer/day (12% powder concentration) were divided into treated (T) control (C) groups. A preliminary vitro antibiotic activity test SMCFA performed several bacterial...
In recent years, due to the growing phenomenon of antimicrobial resistance, search for alternative strategies antibiotic treatments is increasing and a considerable interest use medical honey in clinical practice has emerged. Honey been used treatment skin lesions, both humans animals. However, knowledge concerning non‑traditional companion animals scarce. The aim this study was assess antibacterial activity standardized (Revamil, BFactory) against bacterial strains isolated from lesions...
A short-term study was conducted to compare the effect of using poplar wood chips (PWC) instead wheat straw (WS) litter in dairy cows. total 38 lactating Holstein cows (204 ± 119 days milk, 26.9 6.5 kg milk yield [MY]) were housed a tiestall farm for 10-d trial including 5 d adaptation followed by sampling (from 10). Cows divided into 2 homogeneous groups: one group bedded with WS, and second PWC. Both materials provided amount 7 kg/stall per d. Each composed 3 subgroups 6 or cows;...
Essential oils (EOs) and nature identical compounds (NICs) were investigated as potential antimicrobials. They challenged against livestock pathogens responsible for huge economic losses impaired animal welfare. Eight EOs (tea tree, mint, oregano, cinnamon, thyme, clove bud, lavender, rosemary), five NICs (carvacrol, cinnamic aldehyde, terpineol, thymol, menthol) tested on E. coli, S. Typhimurium, aureus MRSA in association with polysorbates (Tween 20 Tween 80) emulsifiers subsequent oral...
Abstract One Health is a multisectorial approach to achieve optimal health and well-being outcomes, recognizing the interconnections between people, animals, plants, their environment. A relevant application represented by antimicrobial resistance. Noteworthy, intensive farming has been frequently associated with abuse of antimicrobials resistance common among microorganisms from food-producing whose transmission humans cannot be excluded. In our survey, prevalence carbapenem- multidrug...