A5053186593- Melanoma and MAPK Pathways
- Cytokine Signaling Pathways and Interactions
- Nuclear Structure and Function
- HER2/EGFR in Cancer Research
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Protein Kinase Regulation and GTPase Signaling
- Genomics and Chromatin Dynamics
- Obesity, Physical Activity, Diet
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Protein Tyrosine Phosphatases
- Bacillus and Francisella bacterial research
- Advanced Breast Cancer Therapies
- Chronic Lymphocytic Leukemia Research
- Physical Activity and Health
- Microbial Inactivation Methods
- Primary Care and Health Outcomes
- Urologic and reproductive health conditions
- DNA Repair Mechanisms
- Bacteriophages and microbial interactions
- Cancer, Hypoxia, and Metabolism
- Chronic Myeloid Leukemia Treatments
- Carbon and Quantum Dots Applications
- Cancer Cells and Metastasis
Brunel University of London
2013-2025
Middlesex London Health Unit
2025
Agricultural Research Service
2025
LabCorp (United States)
2024
St Mary's University Twickenham London
2024
Auckland District Health Board
2024
University of Maryland, Baltimore County
2017-2021
Philadelphia College of Osteopathic Medicine
2019-2021
University of Baltimore
2020
University of Waterloo
2015-2017
Radial chromosome positioning in interphase nuclei is nonrandom and can alter according to developmental, differentiation, proliferation, or disease status. However, it not yet clear when how repositioning elicited.By investigating the of all human chromosomes primary fibroblasts that have left proliferative cell cycle, we demonstrated cells made quiescent by reversible growth arrest, altered considerably. We found with removal serum from culture medium, took less than 15 minutes, required...
Abstract Lamin A/C (LMNA), lamin B1 (LMNB1) and B receptor (LBR) have key roles in nuclear structural integrity chromosomal stability. In this study, we studied the relationships between mRNA expressions of A-type lamins, LMNB1 LBR clinicopathological parameters human breast cancer. Samples cancer tissues (n = 115) associated non-cancerous tissue (ANCT; n 30) were assessed using reverse transcription quantitative PCR. Transcript levels correlated with data. Higher lamins expression seen...
Background Remaining at home is a high priority for many older adults, but the capacity to “age in place” often threatened by environmental barriers. Purpose To describe client-centred occupational therapy modification intervention program and examine impact of on daily activity performance over time. Methods Using competence-environmental press framework, adults was implemented. In this quasi-experimental, single group prospective study, participants' subjective ratings were evaluated...
To date, microarray analyses have led to the discovery of numerous individual 'molecular signatures' associated with specific cancers. However, there are serious limitations for adoption these multi-gene signatures in clinical environment diagnostic or prognostic testing as studies more power need be carried out. This may involve larger richer cohorts and advanced analyses. In this study, we conduct analyses—based on gene regulatory network—to reveal distinct common biomarkers across cancer...
Light-responsive antimicrobial activity is achieved from tuning carbon nanodot structures <italic>via</italic> bromination, a direct result of the heavy atom effect.
Brk, a tyrosine kinase expressed in majority of breast tumors, but not normal mammary tissue, promotes carcinoma cell proliferation. Normal epithelial cells are dependent on cell-cell or cell-matrix interactions for survival and undergo apoptosis after disruption these interactions. Tumor less sensitive to the induction predicted have potential disseminate. We investigated whether Brk has further roles tumor progression by relating its expression grade demonstrating role regulation under...
This paper explores the implementation and impact of Integrated Programme Assessment (IPA) across diverse disciplines in English higher education institutions. IPA is advocated as a framework that focuses on programme outcomes, aligns learning outcomes with assessment practices, enhances authenticity relevance assessments, thereby reducing over-assessment improving student experiences outcomes. Drawing case studies from four institutions—University Nottingham, University Surrey, Brunel...
Abstract Background Preconditioning of the heart ameliorates doxorubicin (Dox)-induced cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted antioxidants, mitoquinone (MitoQ) or SKQ1, would provide better protection against Dox than co-treatment. Methods investigated dose-response relationship MitoQ, and vitamin C on Dox-induced damage H9c2 cardiomyoblasts when drugs were given concurrently with (e.g., co-treatment) 24 h prior to pretreatment). Moreover,...
Summary We have investigated functional outcome of challenging primary chronic myeloid leukaemia (CML) cells with Bcr‐Abl fusion sequence‐directed RNA interference (RNAi). targeted the b3a2 variant, by RNAi, in phase CML cells, and detected strikingly reduced proliferation precursor expressing this variant. Lack an effect a distinct variant confirmed specificity response. Through targeting oncogene human tumour we demonstrated that enhances progenitor cell amplification, RNAi may be suitable...
We have previously reported that continuous in vitro passage the presence of 3T3 feeders a non-tumorigenic adenoma-derived epithelial cell line, designated PC/AA, resulted its becoming immortal. At early PC/AA was normal diploid, whereas every late had an isochromosome 1(q) which led us to suggest abnormalities chromosome 1 may be involved tumour progression. now report isolation 3T3-feeder-independent variant early-passage PC/AA/FI, immortal and remained non-tumorigenic. Each PC/AA/FI again...
Phytochemicals are used often in vitro and vivo cancer research. The plant hormones jasmonates (JAs) control the synthesis of specialized metabolites through complex regulatory networks. JAs possess selective cytotoxicity mixed populations normal cells. Here, direct incubation leaf explants from non-medicinal Arabidopsis thaliana with human breast cells, selectively suppresses cell growth. High-throughput LC-MS identified metabolites. Protein transcript levels cycle regulators were examined...
There is anecdotal evidence of Fetal Pillow® use, but no formal local information on clinician practices and perspectives.
Pregnancy-specific stress predicts birth outcomes. We hypothesized that there is a maternal stress-GR interaction can influence fetal weight. This study examined the relationship between mothers' and attitude towards their pregnancies, placental glucocorticoid receptors (GRs) growth arrest-specific transcript 5 (GAS5) expression, status of GR polymorphism, with infants' weights. GAS5 α were predominant transcripts in both term preterm placentas, being primarily localized...