A5003181280- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Pancreatic function and diabetes
- Gut microbiota and health
- Heart Rate Variability and Autonomic Control
- Ginseng Biological Effects and Applications
- High Altitude and Hypoxia
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Liver Disease Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Diet and metabolism studies
- 3D Printing in Biomedical Research
- Extracellular vesicles in disease
- Metabolism, Diabetes, and Cancer
- Metabolomics and Mass Spectrometry Studies
- Diabetes Treatment and Management
- Autophagy in Disease and Therapy
- Dialysis and Renal Disease Management
- Silk-based biomaterials and applications
- Diabetes and associated disorders
- Corneal Surgery and Treatments
- Drug Transport and Resistance Mechanisms
- Neuroscience of respiration and sleep
- Inflammasome and immune disorders
Southern Medical University
2015-2025
Nanfang Hospital
2011-2025
Affiliated Eye Hospital of Wenzhou Medical College
2024
Wenzhou Medical University
2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
Qingdao University
2024
Qingdao Municipal Hospital
2024
Jiangsu Province Hospital
2014-2023
Hebei University of Technology
2023
Although employed to release growth factors (GFs) for regenerative medicine, platelet-rich plasma (PRP) has been hindered by issues like burst effect. Based on collagen sponge scaffolds (CSSs) modified with polydopamine (pDA), a novel dermal regeneration template (DRT) was designed. However, whether it could efficiently deliver PRP and even foster wound healing remained unclear. In this work, after prepared pDA-modified CSSs (pDA-CSSs) were fabricated, microscopic observation, GFs assay...
Cellular senescence describes a state of permanent proliferative arrest in cells. Studies have demonstrated that diabetes promotes the pathological accumulation senescent cells, which turn impairs cell movement and proliferation. Historically, has been perceived to be detrimental consequence chronic wound healing. However, underlying mechanism causes cells remain diabetic wounds is yet elucidated. Ferroptosis ferritinophagy observed are due iron metabolism disorders, directly associated with...
Abstract Background Previous molecular genetic studies of physiology and pigmentation sheep skin have focused primarily on a limited number genes proteins. To identify additional that may play important roles in coat color regulation, Illumina sequencing technology was used to catalog global gene expression profiles with white versus black color. Results There were 90,006 74,533 unigenes assembled from the reads obtained skin, respectively. Genes encoding for ribosomal proteins keratin...
Diabetes is characterized by a loss and dysfunction of the β-cell. Glucagon-like peptide 1 receptor (GLP-1R) signaling plays an important role in β-cell survival function. It meaningful to identify promising agents from natural products which might activate GLP-1R signaling. In this study, puerarin, diet isoflavone, was evaluated its beneficial effects on pathway. We showed that puerarin reduced body weight gain, normalized blood glucose, improved glucose tolerance high-fat diet-induced...
Abstract Background Diabetic wounds are one of the long-term complications diabetes, with a disordered microenvironment, diabetic can easily develop into chronic non-healing wounds, which impose significant burden on healthcare. In condition, senescent cells accumulate in wound area and suppress healing process. AMPK, as molecule related to metabolism, has close relationship aging diabetes. The purpose this study was investigate effects AMPK activation explore underlying mechanisms. Methods...
Abstract T-cell factor 7-like 2 (TCF7L2) is an important transcription of Wnt/ β -catenin signaling, which has critical roles in -cell survival and regeneration. In preliminary screening assay, we found geniposide, a naturally occurring compound, was able to increase TCF7L2 mRNA level Min6 cells. Here aimed investigate the role geniposide underlying mechanism involved. Geniposide promote by increasing proliferation decreasing apoptosis cultured mouse islets after challenge with diabetic...
Abstract Background Three-dimensional (3D) cultivation with biomaterials was proposed to facilitate stem cell epithelial differentiation for wound healing. However, whether human adipose-derived cells (hASCs) on collagen sponge scaffold (CSS) better differentiate keratinocytes remains unclear. Methods 3D CSS hASC epidermal co-cultured HaCaT at air-liquid interface (ALI) compared two-dimensional (2D) form and without “co-culture” or “ALI.” Cellular morphology, adhesion, growth condition were...
Abstract With the rising global prevalence of diabetes, rate chronic wounds associated with this disease is also escalating. Although mechanisms underlying trend are not fully understood, accumulating evidence suggests a critical role for reactive oxygen species (ROS). Increased blood glucose levels, bacterial infections, and impaired energy utilization lead to an imbalance between oxidative antioxidant responses, resulting in ROS accumulation. The cellular system can manage small amount...
Abstract This study investigates the effects of fat-emulsion-based early parenteral nutrition in patients following hemihepatectomy, addressing a critical gap clinical knowledge regarding after hemihepatectomy. We retrospectively analyzed data from 274 received non-fat-emulsion-based (non-fatty group) and 297 (fatty Fat-emulsion-based significantly reduced levels postoperative aspartate aminotransferase, total bilirubin, direct while minor decreases red blood cell platelet counts were...
The global prevalence of acute and chronic wounds has surged, escalating healthcare burdens necessitating advanced therapeutic strategies for effective wound management. Electrospun nanofibers have emerged as promising biomimetic platforms...
Recent studies showed that alpha cells, especially immature cells and proalpha might be the precursors of beta cells. Exposure to glucagon-like peptide 1 (GLP1) can ameliorate hyperglycemia in diabetic mice restore cell mass. In present study, we adopted single high-dose (60 mg/kg, i.p.) streptozotocin (STZ) model diabetes mellitus (DM) randomly assigned short-tail (SD) rats a normal group, GLP1 groups (50 μ g/kg, 100 200 g/kg), (200 g/kg) with exendin (9-39) LY294002 group. We found...