A5065701309- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Turtle Biology and Conservation
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Respiratory and Cough-Related Research
- Amphibian and Reptile Biology
- Comparative Animal Anatomy Studies
- Olfactory and Sensory Function Studies
- Ichthyology and Marine Biology
- Animal Behavior and Reproduction
- Veterinary Equine Medical Research
- Bat Biology and Ecology Studies
- Paleontology and Evolutionary Biology
- Physiological and biochemical adaptations
- Nasal Surgery and Airway Studies
- Pediatric health and respiratory diseases
- Aquatic Invertebrate Ecology and Behavior
- Immunotherapy and Immune Responses
- Primate Behavior and Ecology
- Fossil Insects in Amber
- Entomological Studies and Ecology
- Identification and Quantification in Food
- Cervical and Thoracic Myelopathy
- Mast cells and histamine
Vienna Challenge Chamber
2012-2024
University of Vienna
2004-2023
Allergiezentrum Wien West
2005-2011
Jackson Memorial Hospital
2004
Memorial Medical Center
2004
We have developed a recombinant B cell epitope-based vaccine (BM32) for allergen-specific immunotherapy (AIT) of grass pollen allergy. The contains fusion proteins consisting allergen-derived peptides and the hepatitis surface protein domain preS as immunological carrier.We conducted randomized, double-blind, placebo-controlled AIT study to determine safety, clinical efficacy mechanism three subcutaneous injections BM32 doses adsorbed aluminum hydroxide versus (placebo) applied monthly...
Abstract Background CRTH 2 mediates activation of Th2 cells, eosinophils and basophils in response to prostaglandin D . The antagonist OC 000459 has previously been demonstrated reduce airway inflammation improve lung function moderate persistent asthma. objective the present study was determine involvement promoting nasal ocular symptoms allergic subjects exposed grass pollen. Methods A single centre, randomised, double‐blind, placebo‐controlled, two‐way crossover conducted 35 male pollen...
Allergen exposure chambers (AECs) can be used for controlled to allergenic and non-allergenic airborne particles in an enclosed environment, order (i) characterize the pathological features of respiratory diseases (ii) contribute accelerate clinical development pharmacological treatments allergen immunotherapy allergic disease tract (such as rhinitis, rhinoconjunctivitis, asthma). In guidelines European Medicines Agency products (AIT), role AECs determining primary endpoints dose-finding...
SUMMARY The kinematics of feeding on fish have been studied in the aquatic specialist Chelus fimbriatus, fringed turtle, to provide a basic description complete cycles. Anatomical findings supplement kinematic results. High-speed video (500 frames s-1) recordings and X-ray film (150 are used analyse variables characterizing head, hyoid, oesophageal prey movements. high velocities, especially mouth opening, forward thrust head suction prey, unique among turtles comparable with those...
Current pharmacotherapy for allergic rhinitis (AR) does not totally ameliorate all symptoms patients. Residual could be due to nasal neuronal hyperresponsiveness caused by stimulation of the ion channel transient receptor potential vanilloid 1 (TRPV1). SB-705498 is a TRPV1 antagonist that has been developed in an intranasal formulation treatment AR.This randomized, double-blind, 3-way incomplete block crossover study evaluated effects 8 days with 12 mg alone, plus fluticasone propionate 200...
BackgroundHouse dust mite (HDM) allergens are major elicitors of allergic reactions worldwide.ObjectiveIdentification, characterization, and evaluation diagnostic utility a new important HDM allergen was performed.MethodsA cDNA coding for Dermatophagoides pteronyssinus (Dp) allergen, Der p 37, isolated from Dp expression library with patients' IgE antibodies. Recombinant 37 (rDer 37) expressed in Escherichia coli purified, then characterized by mass spectrometry, circular dichroism,...
Purpose: Nonpharmacological, barrier-forming nasal sprays are used to manage symptoms of allergic rhinitis. We aim evaluate the safety and effectiveness Callergin (investigational product, IP), a spray containing iota-carrageenan, in treatment rhinitis (AR). Methods: In this randomized, controlled, crossover trial, adults with grass pollen allergy underwent sequence IP, VisAlpin (comparator CP), no random order. Treatment blocks consisted prophylactic administration assigned or treatment,...
To compare the onset and duration of action new antihistamine levocetirizine with that second-generation fexofenadine using Vienna Challenge Chamber (VCC). The latter is an environment where subjects can be exposed to specific aeroallergens in controlled reproducible conditions allowing for precise comparisons anti-allergic drugs.Ninety-four received a single dose 5 mg, 120 mg or placebo random order three-way cross-over design. On day 1, were grass pollens (1500 grains/m(3)) VCC over period...
Several studies indicate that Der p 7 is an important and clinically relevant allergen of Dermatophagoides pteronyssinus which should be included in vaccines for treatment house dust mite (HDM) allergy. Aim this study was to characterize the IgE epitopes 7.Recombinant expressed purified, analyzed fold by circular dichroism tested its allergenic activity basophil activation. Seven overlapping, surface-exposed peptides (P1-P7) with a length 27 37 amino acids, spanned sequence, were synthesized...
ABSTRACT Feeding mechanics of vertebrates depend on physical constraints the surrounding media, water or air. Such functions are inseparably combined with form. The aim this study is to show linkage for pleurodiran freshwater turtle Pelusios castaneus and, additionally, point out major functional and biomechanical distinctions between aquatic terrestrial feeding turtles as well several intermediate forms. Gross morphological investigations skull, hyoid, tongue, connected musculature,...
Abstract The feeding apparatus of the fringed turtle Chelus fimbriatus (Schneider, 1783) was studied to elucidate mechanics an aquatic specialist that has never been investigated in detail before, regarding gross morphology. skull and hyoid as well associated musculature were examined by computer tomography dissection; tongue scanning electron microscopy. flat skull, possibility enormously depress mandible combined with a cheek-like development, large, ossified apparatus, well-distensible...
So far, only a few biomarkers in allergen immunotherapy exist that are associated with clinical benefit. We thus investigated pilot study whether innate molecules such as the molecule lipocalin-2 (LCN2), implications immune tolerance demonstrated other fields, may discriminate A) between allergic and non-allergic individuals, B) patients clinically responding or non-responding to sublingual (SLIT) house dust mite (HDM) extract. Moreover, we assessed haematological changes potentially...
Arginine kinase (AK) was first identified as an allergen in the Indian-meal moth and subsequently shown to occur various invertebrates shellfish. The cDNA coding for AK from house dust mite (HDM) species Dermatophagoides pteronyssinus, Der p 20, has been isolated, but no recombinant 20 (rDer 20) produced characterized so far. We report expression of protein Escherichia coli. rDer purified be a monomeric, folded by size exclusion chromatography circular dichroism spectroscopy, respectively....
BackgroundChronic hepatitis B virus (HBV) infections are a global health problem. There is need for therapeutic strategies blocking continuous infection of liver cells. The grass pollen allergy vaccine BM32 containing the preS domain large HBV surface protein (LHBs) as immunogenic carrier induced IgG antibodies in human subjects inhibiting vitro. Aim this study was quantification, epitope mapping and investigation genotype cross-reactivity preS-specific treated with different dosage regimens...