Although the disk diffusion method is a useful and widely utilized antimicrobial susceptibility testing in clinical veterinary practice, available breakpoints (CBPs) for combination of bacterial species antimicrobials are still limited. This study aimed to establish tentative cut-off values by analyzing relationship between minimum inhibitory concentration inhibition zone diameter Pasteurella multocida Mannheimia haemolytica, collected Japanese Veterinary Antimicrobial Resistance Monitoring...

We investigated the prevalence of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in pig slaughterhouses from 2018 to 2022 Japan and isolates were examined for antimicrobial susceptibility genetic characteristics by whole-genome analysis. Although positive LA-MRSA rates on farms (29.6%) samples (9.9%) remained lower than those observed European countries exhibiting extremely high confirmed human infections, these showed a gradually increasing trend over five years....

We have developed a chronic mild stress (MS) mouse model by simply rearing mice on wire net for 3 weeks and investigated the effects of MS glucose homeostasis sleep. showed impaired tolerance disturbed One-week treatment with histamine H1 receptor antagonist (H1RA) ameliorated intolerance improved sleep quality in mice. an increased number mast cells both adipose tissue brain. Inhibition cell function impairment Together, these findings indicate that may represent important...

Patients who receive hematopoietic stem cell transplantation (HSCT) are usually administered a calcineurin inhibitor. Because vancomycin is associated with an increased incidence of nephrotoxicity, neutropenic patients receiving HSCT considered high-risk population for nephrotoxicity vancomycin. We retrospectively compared the efficacy and safety teicoplanin in febrile HSCT.A single-centre, retrospective cohort study was conducted at 614-bed Gifu University Hospital Japan. received were or...

Anti-aminoacyl-tRNA synthetase (ARS) antibodies form a condition called Antisynthetase syndrome (ASSD). While interstitial lung disease (ILD) is particularly frequent manifestation of ASSD and closely associated with morbidity mortality, few studies have been conducted on its characteristics high-resolution computed tomography (HRCT). In this study, we clarified the HRCT findings in patients anti-ARS antibody-positive ILD (ARS-ILD). Methods: The at time diagnosis 24 ARS-ILD were...

The Japanese Veterinary Antimicrobial Resistance Monitoring System (JVARM) was established for nationwide monitoring of antimicrobial-resistant bacteria isolated from animals. Here, antimicrobial resistance Escherichia coli and Enterococcus spp. isolates diseased healthy dogs cats investigated. Isolates were collected in 2018 to 2020. Minimum inhibitory concentrations determined 1873 E. 1383 isolates. most commonly resistant nalidixic acid [diseased dog (DD), 62.1%; cat (DC), 59.9%; (HD),...

Nutritional state in the gestation period influences fetal growth and development. We hypothesized that undernutrition during would affect offspring sleep architecture and/or homeostasis. Pregnant female mice were assigned to either control (fed ad libitum; AD) or 50% dietary restriction (DR) groups from day 12 parturition. After parturition, dams fed AD chow. weaning, pups also into adulthood. At adulthood (aged 8–9 weeks), we carried out recordings. Although displayed a significantly...

Abstract Insulin is frequently used for glycemic control. Medication errors related to insulin are a common problem medical institutions. Here, we prepared standardized sliding scale (SSI) order sheet and assessed the effect of its introduction. Observations before after introduction SSI template were conducted at Gifu University Hospital. The incidence medication errors, hyperglycemia, hypoglycemia obtained from electronic records. significantly reduced compared with that prior (12/165...

Immune checkpoint inhibitors (ICIs) have shown impressive anti-tumor effects against multiple types of malignancies. Among the wide variety immune-related adverse events (irAEs), thrombocytopenia (ITP) is relatively rare but often clinically significant and life-threatening. However, appropriate treatment for severe ITP has not been determined. We herein report an 82-year-old male patient with non-small-cell lung cancer who developed three weeks after starting third course atezolizumab. The...

While bioavailability of oral voriconazole is known to be >90%, several reports have observed much lower bioavailability. The aim the present study was assess in clinical use by evaluating change serum concentration patients who received intravenous-to-oral switch therapy with same dose voriconazole.A single-centre, retrospective cohort conducted at 614-bed Gifu University Hospital Japan. Patients between 1 January 2011 and 31 December 2018 were enrolled study. We evaluated changes before...

This study investigates the genomic characteristics of canine and feline cefotaxime (CTX, a third-generation cephalosporin)-resistant Escherichia coli using JVARM, Japanese Veterinary Antimicrobial Resistance Monitoring System, nationwide monitoring. In this study, whole-genome sequencing (WGS) was performed on 51 45 CTX-resistant E. isolates, with certain isolates subjected to pulsed-field gel electrophoresis S1 nuclease for plasmid–chromosome separation. The most common blaCTX-M genes were...

Background/Objectives: Evaluating antimicrobial use (AMU) is essential in the investigation and implementation of resistance (AMR) prevention measures. Here, we examined AMU using an index (mg/kg biomass) that considers sales volume livestock biomass Japan from 2011 to 2022. Methods: Antimicrobial volumes were obtained JVARM data, data reliable statistics. Beef cattle, dairy pigs, broiler chickens, layer fish raised freshwater, seawater targeted this study. Results: Tetracycline accounted...

To investigate fosfomycin resistance rates in cattle across Japan, we carried out susceptibility tests. identify the genes contributing to resistance, performed whole-genome sequencing on fosfomycin-resistant strains. Escherichia coli were sampled from healthy (n = 292, combined total 2017, 2020, 2021, and 2022) diseased 73, 2021 2022). Salmonella spp. obtained 74 These samples originated different non-duplicated farms. The MICs measured using an agar dilution method with a breakpoint of 256...

Our previous report indicated that teicoplanin (TEIC) caused fewer adverse effects than vancomycin (VCM) in patients with febrile neutropenia (FN) receiving haematopoietic stem cell transplantation (HSCT). However, we observed breakthrough methicillin-resistant-Staphylococcus haemolyticus (MR-S haemolyticus) infection during TEIC therapy these patients. In this study, sought to compare the incidence of Gram-positive cocci (GPC) VCM and population.A single-centre, retrospective cohort study...

Background: While bioavailability of oral voriconazole is known to be >90%, several reports have observed much lower bioavailability. The aim the present study was assess in clinical use by evaluating change serum concentration patients who received intravenous-to-oral switch therapy with same dose voriconazole. Methods: A single-center, retrospective cohort conducted at 614-bed Gifu University Hospital Japan. Patients between January 1, 2011 and December 31, 2018 were enrolled study. We...

Background : We herein report the use of independent lung ventilation (ILV) for managing acute allograft rejection after single-lung transplantation (SLT) end-stage emphysema. Case presentation A 54-year-old woman was transferred to our hospital with severe hypoxemia and respiratory distress due unilateral disease diffuse alveolar damage in right donor associated hyperinflation left native She unresponsive immunosuppressive medications conventional strategies, so different ventilator...