A5045340664- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Occupational Health and Performance
- GDF15 and Related Biomarkers
- Exercise and Physiological Responses
- Diet and metabolism studies
- Sports Performance and Training
- Body Composition Measurement Techniques
- Thermoregulation and physiological responses
- Genetic Neurodegenerative Diseases
- Hormonal and reproductive studies
- Respiratory Support and Mechanisms
- Muscle activation and electromyography studies
- Growth Hormone and Insulin-like Growth Factors
- Mitochondrial Function and Pathology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neurogenetic and Muscular Disorders Research
- Immune Response and Inflammation
- Inflammatory mediators and NSAID effects
- Cardiovascular and exercise physiology
- Immune cells in cancer
- Sirtuins and Resveratrol in Medicine
- Sports injuries and prevention
United States Army
2022-2025
U.S. Army Research Institute of Environmental Medicine
2022-2025
Boston University
2025
University of Alabama at Birmingham
2017-2023
University of Florida
2013-2020
University of Florida Health Science Center
2020
Skeletal muscle is highly adaptable and has consistently been shown to morphologically respond exercise training. growth during periods of resistance training traditionally referred as skeletal hypertrophy, this manifests increases in mass, thickness, area, volume, fiber cross-sectional area (fCSA). Delicate electron microscopy biochemical techniques have also used demonstrate that promotes ultrastructural adaptations within fibers. Decades research physiology promulgated a widespread...
The Forkhead boxO (FoxO) transcription factors are activated and necessary for the muscle atrophy during several pathophysiological conditions, including disuse cancer cachexia. Yet, mechanisms which lead to FoxO activation not well defined. Recent data from our lab others indicate that activity of is repressed under basal conditions via reversible lysine acetylation, becomes compromised catabolic conditions. purpose current study was therefore determine extent histone deacetylase (HDAC)...
Evidence from cachectic cancer patients and animal models of cachexia supports the involvement Forkhead box O (FoxO) transcription factors in driving cancer-induced skeletal muscle wasting. However, genome-wide gene networks associated biological processes regulated by FoxO during are unknown. We hypothesize that is a central upstream regulator diverse may act coordinately to promote wasting phenotype. To inhibit endogenous DNA-binding, we transduced limb diaphragm muscles mice with AAV9...
Cancer cachexia is characterized by a continuous loss of locomotor skeletal muscle mass, which causes profound weakness. If this atrophy and weakness also occurs in diaphragm muscle, it could lead to respiratory failure, major cause death patients with cancer. Thus, the purpose current study was determine whether colon-26 (C-26) cancer fiber compromises ventilation. All types were significantly atrophied C-26 mice compared controls, atrophy-related genes, atrogin-1 MuRF1, increased. Maximum...
The popularity of physique sports is increasing, yet there are currently few comprehensive nutritional guidelines for these athletes. Physique sport now encompasses more than just a short phase before competition and offseason have recently been published. Therefore, the goal this review to provide an extensive guide male female athletes in contest preparation recovery period. As optimal protein intake largely related one's skeletal muscle mass, current evidence supports range 1.8-2.7 g/kg....
Skeletal muscle wasting is a devastating consequence of cancer that contributes to increased complications and poor survival, but not well understood at the molecular level. Herein, we investigated role Myocilin (Myoc), skeletal hypertrophy-promoting protein showed downregulated in multiple mouse models cachexia. Loss Myoc alone was sufficient induce phenotypes identified cachexia, including fiber atrophy, sarcolemmal fragility, impaired regeneration. By 18 months age, mice deficient...
Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently consumed by athletes to manage muscle soreness, expedite recovery, or improve performance. Despite the prevalence of NSAID use, their effects on soreness and performance, particularly when administered prophylactically, remain unclear. This randomized, double-blind, counter-balanced, crossover study examined effect consuming a single dose each three NSAIDs (celecoxib, 200 mg; ibuprofen, 800 flurbiprofen, 100 mg) placebo 2 h before...
Background Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, flurbiprofen, naproxen sodium, and indomethacin are commonly employed for their pain-relieving inflammation-reducing qualities. NSAIDs work by blocking COX-1 and/or COX-2, enzymes which play roles in inflammation, fever, pain. The main difference among lies affinity to these enzymes, turn, influences prostaglandin secretion, skeletal muscle growth regeneration. current study investigated the effects of on human cells,...
Although research supports selecting steeper routes to minimize metabolic rate (Ṁ) in mountain racers, the "steeper is cheaper" strategy has yet be confirmed for slower, more typical graded walking speeds under cold stress. Confirm whether true individuals exposed incremental Fourteen healthy, military-age adults (age, 24 ± 6 years; height, 1.72 0.08 m; body mass, 72 16 kg) completed four 20-min treadmill walks three ambient temperatures (20, 10, and 0 °C) light clothing (i.e., shorts,...
Cellular inflammatory response, mediated by arachidonic acid (AA) and cyclooxygenase, is a highly regulated process that leads to the repair of damaged tissue. Recent studies on murine C2C12 cells have demonstrated AA supplementation myotube hypertrophy. However, has not been tested primary human muscle cells. Therefore, purpose this study was determine whether similar effects Proliferating differentiating myoblasts were exposed in dose-dependent manner (50-0.80 µM) for 48 (myoblasts) or 72...
Bioelectrical impedance analysis (BIA) systems are gaining popularity for use in research and fitness assessments as the technology improves becomes more affordable easier to use. Multifrequency BIA (MF-BIA) may improve accuracy precision using octopolar contacts segmental analyses.
Cancer cachexia is a syndrome characterized by profound cardiac and diaphragm muscle wasting, which increase the risk of morbidity in cancer patients due to failure cardiorespiratory system. In this regard, relies greatly on mitochondria meet energy requirements for contraction mitochondrial dysfunction can result weakness fatigue. addition, are major source reactive oxygen species (ROS) production, stimulate increased rates protein degradation. Therefore, it has been suggested that may be...
The cadets in the U.S. Army Reserve Officers' Training Corps (ROTC) consist of students from varied backgrounds. As part collegiate ROTC programs, must pass fitness tests and adhere to body composition standards addition completing their education. previous test record was Physical Fitness Test (APFT), but it recently changed Combat (ACFT) better soldiers for combat capabilities. standardized scoring, ACFT is no longer separated by sex or age as APFT, rather job duty. purpose this study...
Nutritional ketosis as a therapeutic tool has been extended to the treatment of metabolic diseases, including obesity, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD). The purpose this study was determine whether dietary administration ketone ester (KE) R,S-1,3-butanediol diacetoacetate (BD-AcAc
Parkinson's disease (PD) is a common neurodegenerative disorder impacting cognition, movement, and quality of life in >10 million individuals worldwide. We recently characterized quantified skeletal muscle pathology PD represented by exaggerated type I myofiber grouping presumed to result from denervation-reinnervation processes. Our previous findings indicated that impaired neuromuscular junction integrity may be involved grouping, which associated with excessive motor unit activation...
The aim of this study was to examine the effects a ketone ester (KE)-supplemented diet on energy expenditure (EE) and adiposity in mice housed at 23 °C versus thermoneutrality (30 °C), which sympathetic nervous system activity is diminished.Thirty-two 10-week-old male C57BL/6J were assigned 1 4 groups (n = 8 per group): 30% KE + (KE23), control (CON) (CON23), 30 (KE30), or CON (CON30). pair-fed average intake consuming (ad libitum) for weeks. Body composition components balance measured...
Purpose The purpose of this paper is to study the attributes that influence perceptions customer service in retail banking setting from a non‐customer perspective. Design/methodology/approach This research employs mystery shopping approach identify and measure key predict likelihood an individual's choosing location. Findings measures employed accurately predicted positive negative outcomes based on respondent choices. data suggest personal elements may be critical importance cultivating new...