A5108060577- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Cardiac Imaging and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac Health and Mental Health
- Cardiac Arrhythmias and Treatments
- Coronary Interventions and Diagnostics
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Microscopic Colitis
- Cardiac electrophysiology and arrhythmias
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Inflammatory Bowel Disease
- Peripheral Artery Disease Management
- Parathyroid Disorders and Treatments
- ECG Monitoring and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Cardiomyopathy and Myosin Studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiac and Coronary Surgery Techniques
- Medical Imaging Techniques and Applications
- Pancreatic and Hepatic Oncology Research
University of Tsukuba
2025
Hokushin General Hospital
2013-2022
Akita University
2013-2022
Advanced Science Research Center
2021
Shinshu University
1996-2019
Nagano Municipal Hospital
2019
Seoul National University Hospital
2013
Azienda Ospedaliero Universitaria San Giovanni Battista
2013
University of Turin
2013
Türkiye Yüksek İhtisas Hastanesi
2013
PAD peripheral arterial disease PCI percutaneous coronary intervention peak V ˙O2 oxygen uptake PH pulmonary hypertension PVCs premature ventricular contraction QOL quality of life RCT randomized controlled trial RPE rating perceived exertion SGA Subjective Global Assessment STEMI ST elevation myocardial infarction TG triglyceride TAVI transcatheter aortic valve implantation VAD assist device ˙CO2 carbon dioxide output ˙E minute ventilation ˙E/V ventilatory equivalent for vs. slope ˙O2/HR...
1,1-Difluoroallenes underwent regioselective [2 + 2] and [3 cycloadditions with aldehydes using Au(I) catalysts. An AuCl catalyst enabled an α,β-selective cycloaddition of 1,1-difluoroallenes, yielding (E)-3-alkylidene-2,2-difluorooxetanes. Conversely, AuCl(IPr)-AgSbF6 facilitated α,γ-selective cycloaddition, followed by dehydrofluorination to produce aromatized 2-fluorofurans. DFT calculations (B3LYP level) suggested that the former reaction proceeded through Au(III)-containing...
TANAKA, H., et al. : Successful Prevention of Recurrent Ventricular Fibrillation by Intravenous Isoproterenol in a Patient with Brugada Syndrome. administration isoproterenol restored the ST‐segment configuration to nearly normal right precordial leads and completely prevented spontaneous VF attacks patient syndrome. The formation Brugada‐type ECG has been attributed transmural dispersion repolarization ventricular epicardium related modulation autonomic nervous system. Our case may provide...
Nuclear factor-kappaB (NFkappaB) plays a significant role in the coordinated transactivation of cytokine, inducible NO synthase (iNOS), and adhesion molecule genes. Although inflammation is an essential pathological feature myocarditis, NFkappaB this process remains obscure. We examined progression rat experimental autoimmune myocarditis (EAM) tested hypothesis that blockade with decoy against cis element can prevent EAM. Lewis rats were immunized purified porcine cardiac myosin to establish...
We explored the mechanism through which patients sometimes show immunosuppression after cardiac surgery. To test hypothesis that commonly used drugs could cause apoptosis of immune cells, proapoptotic effects heparin and catecholamines (dopamine dobutamine) on peripheral blood lymphocytes were evaluated. Peripheral purified from samples normal healthy volunteers. These cells cultured in presence heparin, dobutamine or dopamine. The was quantified by Annexin V fluorescent assay, DNA content...
FTY720 is a new immunosuppressant agent and selectively decreases the number of circulating lymphocytes. In this study, we compared effects with those tacrolimus on experimental autoimmune myocarditis (EAM) in rats. A significant decrease lymphocyte counts was noted after single administration normal At day 0, 7-week-old male Lewis rats were immunized purified porcine cardiac myosin emulsified complete Freund's adjuvant. or administered intraperitoneally daily. The myocarditis-affected areas...
BACKGROUND Our objective was to assess phasic coronary blood flow and velocity characteristics of the proximal portion left anterior descending artery evaluate their relation clinical hemodynamic manifestations in patients with aortic valve disease. METHODS AND RESULTS We examined 26 chronic regurgitation (AR), 12 predominant stenosis (AS), 11 control subjects using an intravascular Doppler catheter spectral analysis. Angiographic assessment AR identified 10 mild 16 severe regurgitation. The...
Caerulein, a decapeptide chemically related to CCK-8, was administered intramuscularly 20 patients with chronic schizophrenia in two different doses of 0.3 and 0.6 microgram/kg. BPRS ratings were made before 3 weeks after the injection. The neuroleptic therapy not discontinued, but both drug dose changed at least first injection during study period. Clinically obvious statistically significant improvement psychotic symptoms occurred shortly caerulein. greatest change 1--2 later. There an...
Objective: Implantation of bone marrow mononuclear cells (BM-MNCs), including endothelial progenitor cells, into ischemic lower limbs has been shown to improve symptoms in patients with peripheral arterial diseases (PAD). This study investigated whether BM-MNC implantation (BMI) is also effective for the hands these patients.Methods: Seven PAD hand ischemia were enrolled: six had thromboangiitis obliterans and one collagen disease. All seven involving either resting pain or non-healing...
Little is known about the relationship between body composition indicators, including mass index (BMI), fat (FMI) and lean BMI (LBMI), adverse outcomes after percutaneous coronary intervention (PCI) in Asian populations. The aim of this study was to clarify relationship.The SHINANO registry a prospective, observational, multicenter cohort that enrolled 1923 consecutive patients with heart disease (CHD) from August 2012 July 2013; 66 were excluded because missing data. We evaluated 1857 CHD...
Leucine-rich alpha-2 glycoprotein (LRG) is a novel biomarker for monitoring disease activity in inflammatory bowel (IBD). The aim of this study was to evaluate its utility activity. In retrospective based on case records between August 2020 and July 2021 at our two centers, we examined the correlation serum levels LRG C-reactive protein (CRP) with IBD patients. Background factors related were also analyzed. Overall, 47 Crohn's (CD) 123 ulcerative colitis (UC) patients evaluated. CD, CRP...
Background: The clinical outcomes of elderly patients (≥80 years old) undergoing percutaneous coronary intervention (PCI) has not been well established, despite recent advances in both devices and techniques. Methods Results: We recruited from the SHINANO Registry, a prospective, observational, multicenter, cohort study. From August 2012 to July 2013, total 1,923 consecutive with 2,250 elective/urgent PCIs (2,105 admissions) (mean age, 71±11 years; ≥80 years, 23%; men, 77%) were enrolled....
Disruption of cancer screening programs and diagnoses gastrointestinal cancers by the COVID-19 pandemic has been reported; however, little attention paid to situation in depopulated areas with low infection rates. Akita Prefecture is one most Japan lowest rate per capita; at same time, prefecture top-ranked for mortality due years. In this population-based study Prefecture, we investigated occurrence number procedures over five-year period 2016-2020, employing a database from collaborative...
Proliferation, differentiation, and morphogenesis of the intestinal epithelium are tightly regulated by a number molecular pathways. Coordinated action intestine is achieved gastrointestinal hormones, most which exert these actions through G-protein-coupled receptors. We herein investigated role Gαq/11-mediated signaling in homeostasis.Intestinal tissues from control (Gnaqflox/floxGna11+/+ ), Int-Gq knock-out (KO) (VilCre+/-Gnaqflox/floxGna11+/+ G11 KO (Gnaqflox/floxGna11-/- Int-Gq/G11...
Phlegmonous gastritis is a rare but often fatal acute pyogenic infection of the stomach. We herein report three cases phlegmonous with different causes: long-term placement nasogastric feeding tube, bacteremia associated cellulitis in diabetic patient, and an adverse reaction to paclitaxel/carboplatin chemotherapy for cancer unknown primary cause, which were classified as primary, secondary, idiopathic types, respectively. Coping increasing morbidity rate diverse background such patients...