A5015272640- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- Nutrition, Genetics, and Disease
- Moyamoya disease diagnosis and treatment
- Functional Brain Connectivity Studies
- Blood Pressure and Hypertension Studies
- Health, Environment, Cognitive Aging
- Blood Coagulation and Thrombosis Mechanisms
- Alzheimer's disease research and treatments
- Connective tissue disorders research
- Cerebrospinal fluid and hydrocephalus
- Cardiovascular and exercise physiology
- Vitamin D Research Studies
- Obesity and Health Practices
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Cancer Genomics and Diagnostics
- Aortic aneurysm repair treatments
- Medical Imaging and Analysis
- Complement system in diseases
Vanderbilt University Medical Center
2018-2024
Vanderbilt University
2019-2022
To cross-sectionally relate multiple small vessel disease (SVD) neuroimaging markers to cognition among older adults.
Neuroaxonal damage may contribute to cognitive changes preceding clinical dementia. Accessible biomarkers are critical for detecting such damage.
Global longitudinal strain (GLS), reflecting total shortening of the myocardium during cardiac cycle, has emerged as a more precise myocardial function measure than left ventricular ejection fraction (LVEF). Longitudinal may be selectively affected in subclinical heart disease, even presence normal LVEF. This study examines dysfunction, assessed by GLS and LVEF, cognition among older adults.
Subclinical cardiac dysfunction is associated with decreased cerebral blood flow, placing the aging brain at risk for Alzheimer's disease (AD) pathology and neurodegeneration.This study investigates association between subclinical dysfunction, measured by left ventricular ejection fraction (LVEF), cerebrospinal fluid (CSF) biomarkers of AD neurodegeneration.Vanderbilt Memory & Aging Project participants free dementia, stroke, heart failure (n = 152, 72±6 years, 68% male) underwent...
Abstract With age, acquired mutations can cause clonal expansion of hematopoietic stem cells (HSC). This hematopoiesis indeterminate potential (CHIP) leads to an increased predisposition numerous diseases including blood cancer and cardiovascular disease. Here, we report multi- ancestry genome-wide association meta-analyses CHIP among 323,112 individuals (19.5% non-European; 5.3% have CHIP). We identify 15 significant regions nominate additional loci through multi-trait analyses, highlight...
While it is known that vitamin D deficiency associated with adverse bone outcomes, remains unclear whether low status may increase the risk of a wider range health outcomes. We had opportunity to explore association between common genetic variants both 25 hydroxyvitamin (25OHD) and binding protein (DBP, encoded by
Abstract Background There has been great progress towards identifying plasma biomarkers for Alzheimer’s disease (AD), though few studies have investigated interactions between proteomic measures and AD pathology. We aimed to identify proteins predictive of episodic memory decline, an early clinical sign AD, assess whether such associations were altered by the presence Method Vanderbilt Memory Aging Project participants (n=350, 73±7 years, 41% female) without dementia at baseline underwent...
Abstract Background Subjective cognitive decline (SCD), a potential harbinger of Alzheimer’s disease (AD), has been cross‐sectionally associated with neurodegeneration and cerebrovascular markers on brain MRI. However, longitudinal associations are less clear few existing studies that yield inconsistent findings. Here, we related baseline SCD to structural hemodynamic health in older adults free clinical dementia stroke. Methods Vanderbilt Memory & Aging Project participants (n=299,72±7...
Abstract Background Recent technological advances have enabled large‐scale proteomic profiling of plasma and especially in studies Alzheimer’s disease. However, that comprehensively examined longitudinal cognitive decline as an outcome from protein levels prior to the onset clinical dementia are limited. This project aimed identify proteins predictive across a robust neuropsychological protocol over 7‐year follow‐up period. Methods Vanderbilt Memory Aging Project participants (n = 333, 73±7...
Abstract Background Von Willebrand Factor (VWF), a multimeric glycoprotein involved in hemostasis, and ADAMTS13, metalloproteinase that cleaves VWF, are associated with dementia risk. In vitro studies endothelial cells expressing apolipoprotein E ( APOE) ‐ε4 overexpress VWF but no clinical have investigated interactions between or ADAMTS13 APOE status predicting brain health. We assessed whether levels predict longitudinal cognitive decline atrophy, especially carriers. Methods Vanderbilt...
Among older adults, amyloidosis, tauopathy, and neurodegeneration are related to episodic memory decline, which relies on the integrity of medial temporal lobe structures. However, in cognitively normal elders, white matter may relate more closely performance. We examined association different neuroimaging cerebrospinal fluid (CSF) biomarkers brain health with verbal memory, assessed by 12-word Philadelphia Verbal Learning Test (PVLT), elders. Vanderbilt Memory & Aging Project participants...
Cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) changes precede clinical dementia. However, it is unclear how CBF CVR relate to memory trajectory, particularly among carriers of APOE-ε4, a molecular modifier vascular disease strong genetic risk factor for Alzheimer's (AD). Vanderbilt Memory & Aging Project participants free stroke or dementia (n=282, 73±7 years, 40% female) underwent T1-weighted magnetic resonance imaging (MRI) quantify gray matter volume, pseudo-continuous...
The Circle of Willis (CoW) is comprised seven arterial segments forming the main circulatory anastomosis distributing cerebral blood flow (CBF). circle plays an essential role in both collateral circulation and as a pressure diffuser to protect downstream microvasculature from injury. Given that fully patent circles are uncommon communicating arteries most commonly missing segments, this study examined their potential physiological significance. We investigate if smallest CoW including...
Aortic stiffening is an early marker of cardiovascular compromise that increases with age and linked to cerebral gray matter atrophy, white microstructure damage, microvascular alterations. also associated worse cognition increased risk for Alzheimer's disease (AD) in clinical epidemiological cohorts. Mechanisms underlying these associations are poorly understand but may include transmission harmful pulsatile energy due a reduction aortic compliance, leading damaged distal vessels ischemic...
Clinical and epidemiological research suggests subclinical cardiovascular dysfunction relates to cognitive impairment, smaller brain volume, incident Alzheimer's disease (AD). However, the exact mechanism underlying these associations direction of effects remains unknown. This study aims assess whether transgenic mouse models AD (including APPSWE/PSEN1dE9 5XFAD) have compromised function relative age-matched wildtype mice. mice (n=6) littermates (n=9) underwent high resolution echocardiogram...
Prior work has identified an “Alzheimer's disease (AD) imaging signature” reflecting brain regions most vulnerable to AD-specific neurodegeneration that differentiates individuals with normal cognition from clinical AD. The neuropathology associated the regionally specific atrophy remains unclear. This study relates cerebrospinal fluid (CSF) biomarkers of AD (amyloid-beta (Aβ42), hyperphosphorylated tau (p-tau)); (total (t-tau)); axonal injury (neurofilament light (NFL)); and synaptic...
Vessel wall imaging (VWI) is a novel neuroimaging technique offering insight into intracranial vessel morphology. Previous data suggest lumen diameters relate to systemic vascular outcomes, but associations with cerebral small disease (SVD) remain unknown. The current study relates artery diameter and thickness SVD among older adults. Vanderbilt Memory Aging Project participants free of clinical stroke heart failure normal cognition (NC, n=55, 74±6 years) mild cognitive impairment (MCI,...
Compromised cardiac strain, a sensitive measure of regional myocardial deformation, is associated with cognitive functions controlled by the temporal lobe, including worse language and episodic memory performances in aging adults. This study investigates association between subclinical dysfunction, measured global longitudinal potential underlying pathological connections, cerebrospinal fluid (CSF) biomarkers AD (beta-amyloid42, Aβ42; hyperphosphorylated tau, p-tau) neurodegeneration (total...
Abstract Background Age‐associated remodeling of cerebral large arteries contributes to worse systemic and brain health in older adults. Vessel wall imaging (VWI) is a neuroimaging technique that offers the critical ability quantify thickness lumen diameter across arterial segments circle Willis (CoW). Inflammation, well‐known feature aging, cerebrovascular disease, Alzheimer’s may be central driver age‐related changes CoW morphology. We investigate if fluid biomarkers inflammation predict...
Abstract Background Age‐associated changes in intracranial large arteries, including hypertrophic and dilatative remodeling, contribute to worse systemic brain health older adults. Vessel wall imaging (VWI) is a novel neuroimaging technique that offers the critical ability quantify thickness lumen diameter across arterial segments of circle Willis (CoW). Research suggests inflammation, well‐known feature aging, cerebrovascular disease, Alzheimer’s may be central driver age‐related CoW...