A5052416412- Molecular Sensors and Ion Detection
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- Analytical Chemistry and Sensors
- Crystallization and Solubility Studies
- Synthesis and biological activity
- Tuberculosis Research and Epidemiology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Biological Evaluation
- Mycobacterium research and diagnosis
- Asymmetric Synthesis and Catalysis
- Ferrocene Chemistry and Applications
- Coordination Chemistry and Organometallics
- Biochemical and Molecular Research
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Organic Light-Emitting Diodes Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Viral Infections and Immunology Research
- Photochemistry and Electron Transfer Studies
- Quinazolinone synthesis and applications
- Synthetic Organic Chemistry Methods
- Molecular Junctions and Nanostructures
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
Bulgarian Academy of Sciences
2014-2025
Institute of Organic Chemistry with Centre of Phytochemistry
2014-2025
Laboratoire de Synthèse Organique
2024
University of Chemical Technology and Metallurgy
2024
Sofia University "St. Kliment Ohridski"
2024
University of Geneva
2009
Agrobioinstitute
2001
Polarity-sensitive dansyl derivatives L1 and L2 were synthesized their ability to sense pollutant metal ions was investigated. All compounds found be highly sensitive towards Cu2+ Hg2+ ions, while being able detect quantify concentrations as low 2.5 μM. Both exhibit positive solvatofluorochromic behaviour, modulated in the presence of water, which turn results fluorescence enhancement via aggregation-induced emission (AIE). Seeking stability water solubility, luminescent L1-based...
This study introduces the synergistic antibacterial activity derived from combination of barbituric acid derivatives with PVC, PMMA and PMMMA polymers. The barbiturates - C1, C2, C3, exhibit potent Minimum Inhibitory Concentration (MIC) values clear selectivity towards Gram-positive bacteria in solution, resulting inhibitory at exceptionally low concentrations (0.19–0.0015 μg/mL). By integrating these within polymeric matrices, an advanced polymer was obtained. novel material facilitates...
This study investigates the creation and analysis of six novel dansyl derivatives (named L1 to L6) their incorporation into PMMA polymers for environmental sensing purposes. The properties these were extensively examined in different solvents solid states. Notably, they exhibited a significant change color depending on solvent's polarity, suggesting potential assessing microenvironmental polarity. Moreover, showed promising capabilities selectively detecting Cu2+ Hg2+ metal ions acetonitrile...
In this work, two new dansyl-derived chemosensors have been designed with the aim of developing a disulfide-cleavage-triggered probe. These stable ligands, containing thioether (L1) and disulfide bridge...
Background/Objectives: New anti-tuberculosis compounds are needed to treat patients infected with multi- or extensively drug-resistant Mycobacterium tuberculosis strains. Studies based on spontaneous in vitro mutagenesis can provide insights into the possible modes of action and resistance mechanisms such new compounds. We evaluated primary response M. aroylhydrazones nitrofuroylamides. Methods: The reference strain H37Rv was cultured solid media at increased concentrations relative MIC....
We report a compelling structure–property relationship in series of four naphthalimide-derived ligands, engineered for the selective and differential detection Hg(II) Cu(II) ions. By integrating dansyl moiety, we induce intramolecular electron transfer that gives rise to two non-redox-innocent dyad systems. Notably, operates through rare chelation-enhanced fluorescence (CHEF) mechanism—an unusual pathway considering heavy atom effect typically associated with mercury. In contrast, dyads...
The excited-state dynamics of five derivatives the GFP-chromophore, which differ by position and nature their substituents, has been investigated in solvents various viscosity polarity rigid media using femtosecond-resolved spectroscopy. In polar low viscosity, like acetonitrile or methanol, fluorescence decays all compounds are multiexponential, with average lifetimes order a few picoseconds, whereas matrices (polymer films temperature glasses), they single exponential nanoseconds quantum...
Three novel bis-dansyl derivatives bearing a sulfur bridge have been synthesized, fully characterized, and their photophysical characterization studied in solution, as well as, the solid state. All compounds exhibit fluorescence emission with quantum yields up to 60%, which vary significantly depending on solvent used, inherent molecular structure. Moreover, these demonstrate positive solvatofluorochromic behaviour emitting from bluish-green yellow. Kamlet-Taft studies were performed better...
Proton transfer in HBQ and modified compounds was investigated experimentally (steady state absorption emission spectroscopy, NMR chemometrics) theoretically (DFT TD-DFT M06-2X/TZVP calculations) ground excited singlet state.
A straightforward approach to the synthesis of a series 1,2-disubstituted planar chiral ferrocenes was achieved using ortho-directed lithiation ferrocenesulfonamides followed by reaction with electrophilic reactants. The 1,2-functionalized were obtained in good yields, and individual diastereoisomers could be isolated pure form. relative configurations chemical groups positions 1 2, which are relevant for chirality, derived from NMR experiments, absolute configuration determined X-ray...
Abstract Getah virus (GETV) is a re-emerging mosquito-borne alphavirus that highly pathogenic, mainly to pigs and horses. There are no vaccines or treatments available for GETV in swine China. Therefore, the development of simple, rapid, specific, sensitive serological assay antibodies essential prevention control GETV. Current antibody monitoring methods time-consuming, expensive, dependent on specialized instrumentation, these features not conducive rapid detection clinical samples. To...
A new method for direct amidation of unactivated esters with unprecedented substrate scope is developed.
MDL-860 is a broad-spectrum antipicornavirus compound discovered in 1982 and one of the few promising candidates effective vivo virus infection. Despite effectiveness, target mechanism action remain unknown. Here, we have characterized antipoliovirus activity identified host phosphatidylinositol-4 kinase III beta (PI4KB) as target. treatment caused covalent modification irreversible inactivation PI4KB. A cysteine residue at amino acid 646 PI4KB, which locates bottom surface pocket apart from...
The successful design of antitumour drugs often combines in one molecule different biologically active subunits that can affect various regulatory pathways the cell and thus achieve higher efficacy. Two ferrocene derivatives, DK-164 CC-78, with residues were tested for cytotoxic potential on non-small lung cancer lines, A549 H1299, non-cancerous MRC5. demonstrated remarkable selectivity toward cells more pronounced cytotoxicity against A549. CC-78 H1299 was even than well-established...
Chemotherapy is an important tool for controlling enterovirus infections, but clinically effective anti-enterovirus drugs do not currently exist, mainly due to the development of drug resistance. We investigated combination effects replication inhibitors in order limit this process. In previous studies, we showed efficacy consecutive alternating administration triple combinations disoxaril/guanidine/oxoglaucine and pleconaril/guanidine/oxoglaucine against coxsackievirus B1 infection newborn...
Background: Drug resistance is a major cause of cancer treatment failure. Most therapies involve multiple agents, to overcome it. Compounds that exhibit strong anti-tumor effect without damaging normal cells are more and in the focus research. Chemotherapeutic drugs, combining different moieties functional groups one molecule, can modulate regulatory pathways cell thus reach higher efficacy than which affect only cellular process. Methods: We tested recently synthesized ferrocene-containing...