A5021560311- interferon and immune responses
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Single-cell and spatial transcriptomics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Cell Function and Interaction
- Gene expression and cancer classification
- Peptidase Inhibition and Analysis
- Sepsis Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Autophagy in Disease and Therapy
- Coal Combustion and Slurry Processing
- Body Contouring and Surgery
- Urological Disorders and Treatments
- RNA regulation and disease
- Eosinophilic Disorders and Syndromes
- Mitochondrial Function and Pathology
- Bioactive Natural Diterpenoids Research
- Receptor Mechanisms and Signaling
- Genomics, phytochemicals, and oxidative stress
- Extracellular vesicles in disease
- Immune cells in cancer
- Allergic Rhinitis and Sensitization
- Dupuytren's Contracture and Treatments
- Nephrotoxicity and Medicinal Plants
University of Chicago
2020-2024
Osaka University
2012-2024
Tokushima University
2017-2022
Osaka International University
2013-2017
Kobe University
2010
Saitama Medical University
2000
Abstract Sepsis is a systemic response to infection with life-threatening consequences. Our understanding of the molecular and cellular impact sepsis across organs remains rudimentary. Here, we characterize pathogenesis by measuring dynamic changes in gene expression organs. To pinpoint molecules controlling organ states sepsis, compare effects on those 6 singles 15 pairs recombinant cytokines. Strikingly, find that pairwise tumor necrosis factor plus interleukin (IL)-18, interferon-gamma or...
Abstract With its adaptor protein apoptosis-associated speck-like containing a caspase recruitment domain (ASC), Nod-like receptor family, pyrin 3 (NLRP3) forms the inflammasome and mediates inflammatory innate immune responses. Development of an anti-inflammatory drug targeting NLRP3-inflammasome is urgently required because aberrant activation often causes diseases, including gout. We show that resveratrol, natural polyphenol in grapes wine, safe effective phytochemical inhibits...
When host cells are infected by an RNA virus, pattern-recognition receptors (PRRs) recognize the viral and induce antiviral innate immunity. Toll-like receptor 7 (TLR7) detects genomic of incoming murine leukemia virus (MLV) in endosomes mediates response. However, RNA-sensing PRR that recognizes MLV cytosol is not fully understood. Here, we definitively demonstrate zinc-finger protein (ZAP) acts as a cytosolic sensor, inducing degradation transcripts exosome, system, on granules. Although...
The innate immune system senses RNA viruses by pattern recognition receptors (PRRs) and protects the host from virus infection. PRRs mediate production of modulatory factors direct elimination viruses. Here, we show a unique PRR that mediates antiviral response. Tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP ribose) polymerase (TIPARP), Cysteine3 Histidine (CCCH)-type zinc finger-containing protein, binds to Sindbis (SINV) via its finger domain recruits an exosome induce viral...
Abstract Accumulating evidence indicates that type I interferon (IFN) mediates the host protective response to RNA viruses. However, anti-viral effector molecules involved in this have not been fully identified. Here, we show zinc-finger protein (ZAP), an IFN-inducible gene, plays a critical role elimination of Sindbis virus (SINV) vitro and vivo. The loss ZAP greatly enhances replication SINV but does inhibit IFN production primary mouse embryonic fibroblasts (MEFs). binds destabilizes RNA,...
Incidence of type I allergies, such as hay fever, is continuously increasing in developed countries, including Japan. Type allergies are triggered by chemical mediators, histamine, which released via immunoglobulin E (IgE)-mediated mast cell degranulation. Therefore, medications inhibiting the synthesis, release, and receptor binding these mediators commonly used to manage allergy symptoms. As self-care disease prevention practices gaining attention worldwide, regular consumption food...
Nod-like receptor family pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune that senses organelle dysfunction induced by various stimuli, such as infectious, environmental, metabolic and drug stresses. Upon activation, NLRP3 forms an inflammasome with its adaptor protein apoptosis-associated speck-like containing caspase recruitment domain (ASC) caspase-1, to trigger the release of inflammatory cytokines. The development effective anti-inflammatory drugs targeting in high demand...
Abstract The human body is exposed to various particulates of industrial, environmental, or endogenous origin. Invading intrinsic can induce inflammation by aberrantly activating the immune system, thereby causing crystallopathies. When cells such as macrophages phagocytose particulates, their phagolysosomal membranes undergo mechanical damage, eventually leading pyroptotic cell death accompanied release inflammatory cytokines, including interleukin (IL)-1α and IL-1β. nod-like receptor...
Sepsis is a systemic response to infection with life-threatening consequences. Our understanding of the impact sepsis across organs body rudimentary. Here, using mouse models sepsis, we generate dynamic, organism-wide map pathogenesis disease, revealing spatiotemporal patterns effects tissues. These data revealed two interorgan mechanisms key in sepsis. First, discover simplifying principle behavior cytokine network during whereby hierarchical circuit arising from pairwise TNF plus IL-18,...
Invasive colorectal adenocarcinomas have bundles of eosinophilic spindle cells, which are regarded as myofibroblasts, in their desmoplastic stroma, some continuous with the muscularis mucosa.To investigate relation between cells and mucosa based on cytoskeletal phenotypes early invasive adenocarcinoma.Formalin fixed, paraffin wax embedded tissues 17 were immunostained for alpha-smooth muscle actin (alpha-SMA), desmin, vimentin.The phenotype was alpha-SMA positive, desmin vimentin weakly...
The WW domain containing E3 ubiquitin protein ligase 1 (WWP1), which plays an important role in ubiquitin-proteasome pathway to degrade unneeded or damaged proteins, was recently identified as the responsible for chicken muscular dystrophy. Despite intensive studies on oncogenic characters, of WWP1 diseases has not yet been fully understood. Previously, we transfected either wild and mutated types gene into C2C12 mouse myoblasts monitor expression pattern muscle-differentiation markers, so...