Elise Gressier
A5030647999- Acute Myeloid Leukemia Research
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Histone Deacetylase Inhibitors Research
- Immune Response and Inflammation
- Protein Degradation and Inhibitors
- Erythrocyte Function and Pathophysiology
- Inflammasome and immune disorders
- Gut microbiota and health
- Tryptophan and brain disorders
- Pediatric health and respiratory diseases
- Microscopic Colitis
- Cell death mechanisms and regulation
- Hair Growth and Disorders
- Trace Elements in Health
Peter Doherty Institute
2017-2024
The University of Melbourne
2017-2024
Boston Children's Hospital
2019
Centre d’Immunologie de Marseille-Luminy
2018
Centre National de la Recherche Scientifique
2018
Inserm
2018
Whereas CD4 + T cells conventionally mediate antitumor immunity by providing help to CD8 cells, recent clinical studies have implied an important role for cytotoxic in cancer immunity. Using orthotopic melanoma model, we provide a detailed account of antitumoral cell responses and their regulation major histocompatibility complex class II (MHC II) the skin. Intravital imaging revealed prominent interactions with tumor debris-laden MHC host antigen-presenting that accumulated around nests,...
Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during Salmonella infection, we infected mice macrophages deficient for diverse combinations caspases-1, -11, -12, -8 receptor interacting serine/threonine kinase 3 (RIPK3). Loss caspase-8-driven apoptosis, or necroptosis had minor impact on control. However, combined deficiency these pathways caused loss bacterial control in their macrophages,...
Antiviral CD8+ T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these signals for decoding by remains unclear. Here, we describe gradual interferon-α/interferon-β (IFNα/β)-induced transcriptional adaptations that endow APCs with capacity to rapidly activate regulators p65, IRF1 and FOS after CD4+ cell-mediated CD40 stimulation. While responses operate through broadly used signaling components, they induce a unique set...
Pharmacologic inhibition of epigenetic enzymes can have therapeutic benefit against hematologic malignancies. In addition to affecting tumor cell growth and proliferation, these agents may induce antitumor immunity. Here, we discovered a novel immunoregulatory mechanism through histone deacetylases (HDAC). models acute myeloid leukemia (AML), differentiation mediated by the HDAC inhibitor (HDACi) panobinostat required activation type I interferon (IFN) pathway. Plasmacytoid dendritic cells...
Article21 August 2018Open Access Transparent process Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection Elena Tomasello Corresponding Author [email protected] Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France Search for more papers by this author Karima Naciri Rabie Chelbi Gilles Bessou Anissa Fries Elise Gressier Abdenour Abbas Emeline Pollet Philippe Pierre orcid.org/0000-0003-0863-8255 Toby...
Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role regulator cell receptor and cytokine signaling, Ptpn2, in formation function TRM skin. Ptpn2-deficient CD8+ displayed a marked defect generating CD69+ CD103+ response to herpes simplex virus type 1 (HSV-1) skin infection. This was accompanied by reduction proportion KLRG1− precursor transcriptional bias toward terminal differentiation. Of note, forced expression KLRG1 sufficient...
Resolution of virus infections depends on the priming virus-specific CD8+ T cells by dendritic (DC). While this process requires major histocompatibility complex (MHC) class I-restricted antigen presentation DC, relative contribution to cell infected DC is less clear. We have addressed question in context a peripheral infection with herpes simplex 1 (HSV). Assessing endogenous, polyclonal HSV-specific response, we found that effective vivo depended presence subsets specialized...
ABSTRACT Pharmacological inhibition of epigenetic enzymes can have therapeutic benefit, particularly against hematological malignancies. While these agents affect tumor cell growth and proliferation, recent studies demonstrated that pharmacological de-regulation modifiers may additionally mediate anti-tumor immune responses. Here we discovered a novel mechanism regulation through the histone deacetylases (HDACs). In genetically engineered model t(8;21) AML, leukemia differentiation benefit...
<div>Abstract<p>Pharmacologic inhibition of epigenetic enzymes can have therapeutic benefit against hematologic malignancies. In addition to affecting tumor cell growth and proliferation, these agents may induce antitumor immunity. Here, we discovered a novel immunoregulatory mechanism through histone deacetylases (HDAC). models acute myeloid leukemia (AML), differentiation mediated by the HDAC inhibitor (HDACi) panobinostat required activation type I interferon (IFN) pathway....
Supplementary Figure from Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation AML
Supplementary Figure from Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation AML
<div>Abstract<p>Pharmacologic inhibition of epigenetic enzymes can have therapeutic benefit against hematologic malignancies. In addition to affecting tumor cell growth and proliferation, these agents may induce antitumor immunity. Here, we discovered a novel immunoregulatory mechanism through histone deacetylases (HDAC). models acute myeloid leukemia (AML), differentiation mediated by the HDAC inhibitor (HDACi) panobinostat required activation type I interferon (IFN) pathway....