A5016886376- Diabetes Management and Research
- Diabetes and associated disorders
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Bariatric Surgery and Outcomes
- Adrenal Hormones and Disorders
- Birth, Development, and Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pancreatic function and diabetes
- Hormonal Regulation and Hypertension
- Childhood Cancer Survivors' Quality of Life
- Sexual Differentiation and Disorders
- Obesity and Health Practices
- Neonatal Respiratory Health Research
- Testicular diseases and treatments
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Infant Nutrition and Health
- Health and Lifestyle Studies
- Stress Responses and Cortisol
- Eating Disorders and Behaviors
- Pharmacology and Obesity Treatment
- Genetic Syndromes and Imprinting
- Diabetes Treatment and Management
- Metabolism and Genetic Disorders
Sheffield Children's Hospital
2015-2025
Sheffield Children's NHS Foundation Trust
2013-2024
University of Sheffield
2003-2023
Whittington Health NHS Trust
2019
New York Institute of Technology
2016
Boston Children's Hospital
2004-2015
Sheffield Hallam University
2015
Queen Elizabeth Hospital
2013
The University of Adelaide
2013
National Health Service
2006
We conducted a proof-of-concept, randomized, controlled trial to investigate the effects of supervised exercise therapy intervention on psychopathologic outcomes in obese adolescents.The participant sample consisted 81 adolescents (age: 11-16 years) who had been referred children's hospital for evaluation obesity or responded community advertisement. Participants were assigned randomly therapy, an equal-contact placebo intervention, usual care. Intervention participants attended 3 one-on-one...
Childhood obesity is increasingly associated with type 2 diabetes (T2D). Metformin reduces the risk for T2D in adult obese nondiabetic patients, but evidence children and young people inconclusive.The objective of study was to assess effect metformin on body mass index sd score (BMI-SDS), metabolic factors, adipokines.This a prospective, randomized, double-blind, placebo-controlled trial.The conducted at six pediatric endocrine centers United Kingdom.One hundred fifty-one hyperinsulinemia...
Abstract Aims Hybrid closed‐loop (HCL) systems are characterised by integrating continuous glucose monitoring (CGM) with insulin pumps that automate delivery via specific algorithms and user‐initiated delivery. The aim of the study was to evaluate effectiveness HCLs on HbA1c, time‐in‐range (TIR), hypoglycaemia frequency quality life measures in children young people (CYP) T1D, their carers. Methods Patients were recruited prospectively into National Health Service (NHS) England real‐world...
Abstract Hybrid closed-loop (HCL) systems seamlessly interface continuous glucose monitoring (CGM) with insulin pumps, employing specialised algorithms and user-initiated automated delivery. This study aimed to assess the efficacy of HCLs at 12 months post-initiation on glycated haemoglobin (HbA1c), time-in-range (TIR), hypoglycaemia frequency, quality life measures among children young people (CYP) type 1 diabetes mellitus (T1DM) their caregivers in a real-world setting. Conducted between...
Type 1 pseudohypoaldosteronism (PHA) is a rare heterogeneous group of disorders characterised by resistance to aldosterone action. There resultant salt wasting in the neonatal period, with hyperkalaemia and metabolic acidosis. Only after results confirm isolated can diagnosis type PHA be confidently made. further classified into i) renal (autosomal dominant (AD)) ii) multiple target organ defect/systemic recessive (AR)). The aim this case series was characterise mode presentation, management...
Abstract Background Addressing increasing rates of childhood obesity is a global priority. High numbers children and young people are living with experience significant physical mental health impacts. Social prescribing research has shown it can help improve people’s health, meaning may be helpful way to provide additional, personalised support who obesity, address the inequalities experienced by this group. This study aimed an overview current understanding use social from healthcare...
In patients with multiple endocrine neoplasia type 2 (MEN2) syndrome, genetic testing offers early diagnosis, stratifies the risk of developing medullary thyroid cancer (MTC) and informs timing thyroidectomy. The efficacy treatment, which depends on timely safe surgery, is not well established.This was a retrospective review diagnostic clinicopathological outcomes prophylactic thyroidectomy in children MEN2 between 1995 2013 UK. American Thyroid Association (ATA) 2009 guidelines were used as...
In the UK, there have been reports of significant reductions in paediatric emergency attendances and visits to general practitioners due COVID-19. A national survey undertaken by UK Association Children’s Diabetes Clinicians found that proportion new-onset type 1 diabetes (T1D) presenting with ketoacidosis (DKA) during this COVID-19 pandemic was higher than previously reported, has an increase presentation severe DKA at diagnosis children young people under age 18 years. Delayed...
Increasing numbers of very low birth weight (VLBW) infants are surviving into adulthood because improvements in neonatal intensive care. Adverse events early life can have long-term effects through reprogramming metabolic systems.To determine whether young adult VLBW survivors abnormalities skeletal development or endocrine function.Cross-sectional, observational, case-control study.Thirty-seven subjects and 27 healthy controls at peak bone mass (mean age 23).Differences between cases body...
Summary Objective The short synacthen test ( SST ) is widely used to assess patients for adrenal insufficiency, but the frequency and protocols across different centres low‐dose LDT are unknown. This study aimed survey accuracy of ten preparation strategies . Methods Members 6 international endocrine societies were surveyed regarding diagnostic tests in particular Synacthen was diluted concentrations measured using a ELISA Results Survey responses received from 766 individuals 60 countries...
Severe adolescent obesity (body mass index (BMI) >99.6th centile) is a significant public health challenge. Current non-invasive treatments, including community-based lifestyle interventions, are often of limited effectiveness in this population, with NICE guidelines suggesting the use bariatric surgery as last line treatment. Health professionals understandably reluctant to commission and an alternative, intra-gastric balloon adjunct programme might offer reversible, potentially safer less...
Real-time continuous glucose monitoring (rtCGM) and FreeStyle Libre systems (isCGM) are new evolving technologies used in the management of Type 1 diabetes. They offer potential to improve diabetes control reduce hypoglycaemia. rtCGM can be linked insulin pump providing hybrid closed loop therapy. Families children young people keen have benefit from these technologies. These relatively expensive so it is important that health care professionals, families (CYP) with adequately trained use...
Type 2 diabetes in young people is an aggressive disease with a greater risk of complications leading to increased morbidity and mortality during the most productive years life. Prevalence UK globally rising yet experience managing this condition limited. There are no consensus guidelines for assessment management paediatric type diabetes.
A qualitative study nested within a randomized controlled trial explored obese adolescents' experiences of participation in an exercise therapy intervention. Semi-structured interviews were conducted with participants assigned to therapy. Participants' reported feeling more energetic during and after exercise, than before. Many happy/happier expressed better about themselves as individuals the Most felt confident their ability regularly. Greater emphasis needs be placed upon educating...
Intragastric Balloons are a temporary, reversible and safer option compared to bariatric surgery promote significant weight loss, leading improved metabolic outcomes. However, due subsequent regain, alternative procedures now preferred in adults. In adolescents, more amenable lifestyle change, balloons may be an less procedures. Our aim was assess the tolerability efficacy of intragastric balloon severely obese adolescents impact associated loss on biomedical outcomes (glucose metabolism,...
Summary Context Salivary cortisone reflects serum cortisol levels, is more sensitive than salivary at lower values of and noninvasive. Objective To investigate the relationship between following low‐ high‐dose synacthen. Design setting Prospective pharmacodynamic studies in clinical research facilities. Participants intervention Thirty‐five dexamethasone‐suppressed, healthy adult males underwent an intravenous synacthen test: N = 23 low‐dose (1 mcg), 12 (250 mcg). Paired samples were taken...
#### What you need to know Thyroid function tests are often requested when investigating obese or overweight children. Slightly raised thyrotropin (TSH) with normal free thyroxine—subclinical hypothyroidism (hyperthyrotropinaemia)—is a common finding. An isolated is best described as hyperthyrotropinaemia rather than subclinical and by definition excludes people clinical symptoms, positive thyroid antibodies, goitre, associated thyroidal illness.1 2 The adult consensus guideline defines it...
The effects of growth hormone deficiency (GHD) on linear in children are well documented, but there is less convincing evidence regarding the impact health-related quality life (QOL). We examined QOL aged 8-16 years with acquired GHD following treatment for malignancy (AGHD) or idiopathic (IGHD) commencing (GHT) over 6 months. adopted a longitudinal design involving consecutive patients and their families attending clinic an 18-month period. Mothers were invited to complete questionnaires...
There are few data in the paediatric literature on normal cortisol response to stimulation during low dose synacthen test (LDST) (1 microg).To examine responses children, subsequently presumed be normal, who had an LDST anterior pituitary function tests (APFTs).A retrospective review of results children with short stature and growth hormone levels.Of 33 tested, seven suboptimal based accepted criteria (peak <500 nmol/l)--a false positive rate 21%. Only three these a repeat LDST, which was...
Abstract Objective To determine differences between parents and children in ratings of child health‐related quality life ( HRQL ) prior to growth hormone treatment. Method measures were collected from 144 their caregivers. Inclusion criteria aged 10 16 years, diagnosed with T urner's syndrome, acquired or idiopathic deficiency AGHD IGHD eligible begin human GH treatment (GHT), non‐growth deficient GHD short stature. Results Parents rated have poorer physical psychosocial than themselves....
Increasing numbers of severely obese young people undergo bariatric surgery in the USA with reports substantial weight loss after 1 year. National Institute for Clinical Excellence 2006 suggests considering 'exceptional circumstances'. We present six patients operated upon 2004-2012 at our centre UK.Six (4 male) aged 14-16 years (mean age 15.10) underwent surgery. Mean preoperative body mass index (BMI) was 62.7 kg/m(2) and BMI SDS +4.4. Comorbidities included hypertension, insulin...