A5046358832- Diabetes Management and Research
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Education
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Artificial Intelligence in Healthcare
- Liver Disease Diagnosis and Treatment
- Machine Learning in Healthcare
- Lipoproteins and Cardiovascular Health
- Mobile Health and mHealth Applications
- Cardiovascular Function and Risk Factors
- Genetics and Neurodevelopmental Disorders
- Vascular Malformations and Hemangiomas
- Neurogenesis and neuroplasticity mechanisms
- AI in cancer detection
- Pharmacology and Obesity Treatment
- Chronic Disease Management Strategies
- Bipolar Disorder and Treatment
- Cardiovascular Disease and Adiposity
- Sarcoma Diagnosis and Treatment
Seoul St. Mary's Hospital
2016-2025
Catholic University of Korea
2016-2025
Korea Advanced Institute of Science and Technology
2019-2023
Soongsil University
2023
Deleted Institution
2009
University of British Columbia Hospital
2009
Seoul National University Hospital
2009
Seoul National University Children's Hospital
2009
Wooridul Hospital
2009
Chung Cheong University
2009
Insulin resistance is one of the most important contributing factors to cardiovascular disease. This study aimed investigate association between coronary artery stenosis (CAS) and triglyceride glucose index (TyG index), a simple insulin marker, in asymptomatic subjects with type 2 diabetes.We recruited adults diabetes but without previous history heart disease (n = 888). Significant CAS was defined as maximum intraluminal ≥70 % by CT angiography. TyG calculated log [fasting triglycerides...
Abstract Purpose: Brainstem gliomas are usually inoperable and have a dismal prognosis. Based on the robust tropisms of neural stem cells (NSC) mesenchymal (MSC) to brain tumors, we compared tumor-tropic migratory capacities these evaluated therapeutic potential genetically engineered human NSCs encoding cytosine deaminase (CD) IFNβ against brainstem gliomas. Experimental Design: The directed MSCs glioma (F98) were both in vitro vivo. (HB1.F3) various MSCs, such as bone marrow–derived...
Background: This study investigates the impact of fluctuating lipid levels on endothelial dysfunction.Methods: Human aortic and umbilical vein cells were cultured under varying palmitic acid (PA) concentrations: 0, 50, 100 μM, in a variability group alternating between 0 μM PA every 8 hours for 48 hours. In group, exposed to during final before analysis. We assessed inflammation using real-time polymerase chain reaction, Western blot, cytokine enzyme-linked immunosorbent assay (ELISA);...
Abstract Background Suicide is a significant yet preventable public health issue. Body mass index (BMI) readily measurable indicator associated with various outcomes. However, the relationship between BMI and suicidal death risk complex warrants further investigation, particularly within contemporary, non-Western contexts consideration of potential confounders. The purpose this study was to investigate death. Methods This nationwide, retrospective, observational based on Korean National...
BackgroundMost studies focus solely on the relationship between parity and type 2 diabetes mellitus (T2DM) risk, providing limited insights into other contributing or protective factors. This study aims to explore complex T2DM considering additional factors such as obesity, race, body composition. MethodsThis prospective cohort used data from 242,159 women aged 40 69 UK Biobank, none of whom had at baseline. Multivariable Cox proportional hazard models were applied assess association T2DM....
This study investigated the risk of cause-specific mortality according to glucose tolerance status in elderly South Koreans.A total 1,292,264 individuals aged ≥65 years who received health examinations 2009 were identified from National Health Information Database. Participants classified as normal tolerance, impaired fasting glucose, newly-diagnosed diabetes, early diabetes (oral hypoglycemic agents ≤2), or advanced ≥3 insulin). The system-specific and disease-specific deaths was estimated...
Loss of functional β-cell mass is an essential feature type 2 diabetes, and maintaining mature identity important for preserving a mass. However, it unclear how β-cells achieve maintain their identity. Here we demonstrate novel function protein arginine methyltransferase 1 (PRMT1) in Prmt1 knockout fetal adult induced which was aggravated by high-fat diet–induced metabolic stress. Deletion resulted the immediate loss histone H4 3 asymmetric dimethylation (H4R3me2a) subsequent The expression...
The prevalence of young-onset diabetes (YOD) has been increasing worldwide. As the incidence YOD increases, it is necessary to determine characteristics and factors that influence its development associated complications.In this retrospective study, we recruited patients who were diagnosed with type 2 mellitus between June 2001 December 2021 at a tertiary hospital. study population was categorized according age: (age <40 years), middle-age-onset (MOD, 40≤ age <65 late-onset (LOD, ≥65 years)....
The early prediction of diabetes can facilitate interventions to prevent or delay it. This study proposes a model based on machine learning (ML) encourage individuals at risk employ healthy interventions. A total 38,379 subjects were included. We trained the 80% and verified its predictive performance remaining 20%. Furthermore, performances several algorithms compared, including logistic regression, decision tree, random forest, eXtreme Gradient Boosting (XGBoost), Cox XGBoost Survival...
Sodium-glucose co-transporter-2 (SGLT2) inhibitors are a newly developed class of oral anti-diabetic drugs (OADs) with unique mechanism action.This review describes the biochemistry and physiology underlying use SGLT2 inhibitors, their clinical pharmacology, including action posology.The pragmatic placement these molecules in existing OAD arena is also discussed.
Abstract We investigated the risk of developing chronic kidney disease (CKD) in patients with young-onset Type 2 diabetes (YOD, diagnosed age < 40 years). enrolled 84,384 aged 20–64 who started anti-diabetic medication between 2010 and 2011 from Korea National Health Insurance Sharing Service; 1 or a history CKD were excluded. Multivariate logistic regression analyses performed to adjust for YOD-distinct variables compare incidence YOD late-onset (LOD, ≥ During median observation period...
Abstract Pregnancy imposes a substantial metabolic burden on women, but little is known about whether or how multiple pregnancies increase the risk of maternal postpartum diabetes. In this study, we assessed impact in humans and rodent model. Mice that underwent had increased adiposity, their glucose tolerance was initially improved compared to those age-matched virgin mice. Later, however, insulin resistance developed over time, secretory function compensatory pancreatic β cell...
Background Protein arginine methyltransferase 1 (PRMT1) is a major enzyme responsible for the formation of methylarginine in mammalian cells. Recent studies have revealed that PRMT1 plays important roles development various tissues. However, its role pancreas has not yet been elucidated. Methods Pancreatic progenitor cell-specific Prmt1 knock-out (Prmt1 PKO) mice were generated and characterized their metabolic histological phenotypes levels Neurog3 gene expression neurogenin 3 (NGN3)...
The national healthcare systems of every country in the world cannot sustain rise expenditure caused by chronic diseases and their complications. To system, a novel system should be developed to improve quality care minimize costs. For 20 years, our team patient-communicating digital platforms proved efficacy. National scale randomized control trials are underway systematically measure efficacy economic benefits this health system. Precision medicine aims maximize effectiveness disease...
Guidelines for switching to triple combination therapy directly after monotherapy failure are limited. This study investigated the efficacy, long-term sustainability, and safety of either mono or dual add-on using alogliptin pioglitazone patients with type 2 diabetes mellitus (T2DM) who did not achieve their target glycemic range metformin monotherapy.
Statins are common lipid-lowering agents used in dyslipidemia. However, they increase serum creatinine phosphokinase (CPK) levels. Currently, there no studies on the effect of thyroid-stimulating hormone (TSH) levels CPK after statin administration. Therefore, this study aimed to investigate level alterations administration according TSH quartiles participants with euthyroidism.
<sec> <title>BACKGROUND</title> The Digital Education platform, DoctorviceⓇ (iKooB Inc., Seoul, South Korea), offers both physicians' face-to-face education and remote glucose monitoring, which is expected to be effective for personalized diabetes care. </sec> <title>OBJECTIVE</title> To evaluate the effectiveness of digital platform care compare cases where monitoring were provided with only was provided. <title>METHODS</title> Sixty-six patients type 2 mellitus who visited Diabetes Center...
Background: Cardiovascular disease is life-threatening yet preventable for patients with type 2 diabetes mellitus (T2DM). Because each patient T2DM has a different risk of developing cardiovascular complications, the accurate stratification critical. In this study, we proposed engines based on machine-learning algorithms newly diagnosed in Korea.Methods: To develop machine-learning-based engines, retrospectively analyzed 26,166 who visited Seoul St. Mary’s Hospital between July 2009 and...