A5066936667- Vector-borne infectious diseases
- Toxin Mechanisms and Immunotoxins
- Vector-Borne Animal Diseases
- Insect and Pesticide Research
- Metabolism and Genetic Disorders
- Lysosomal Storage Disorders Research
- Herpesvirus Infections and Treatments
- Viral Infections and Vectors
- NF-κB Signaling Pathways
- Insect Resistance and Genetics
- Diet and metabolism studies
- Heat shock proteins research
- Immune Cell Function and Interaction
- Carbohydrate Chemistry and Synthesis
- Insect symbiosis and bacterial influences
- Immune Response and Inflammation
- Amino Acid Enzymes and Metabolism
- T-cell and Retrovirus Studies
- Microtubule and mitosis dynamics
- Mitochondrial Function and Pathology
- Coccidia and coccidiosis research
- Cellular transport and secretion
- Animal Disease Management and Epidemiology
- Helminth infection and control
- Trypanosoma species research and implications
Université de Lille
2001-2024
Centre Hospitalier Universitaire de Lille
2007-2023
Institutul National pentru Sanatatea Mamei si Copilului "Alessandrescu-Rusescu"
2019
Hôpital Jeanne de Flandre
2005-2018
Hôpital Claude Huriez
2006-2018
University of Bern
2006-2017
University of Basel
2013
International Livestock Research Institute
2005
Institut Pasteur
2005
Centre National de la Recherche Scientifique
2005
Despite a significant growth in food production over the past half-century, one of most important challenges facing society today is how to feed an expected population some nine billion by middle 20th century. To meet demand for without increases prices, it has been estimated that we need produce 70–100 per cent more food, light growing impacts climate change, concerns energy security, regional dietary shifts and Millennium Development target halving world poverty hunger 2015. The goal...
Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome compared it with to understand mechanisms underlying transformation tropism. Despite high conservation gene sequences synteny, analysis reveals unequally expanded families species-specific genes. also identify divergent putative secreted polypeptides may reduce immune recognition, candidate regulators host-cell transformation, a Theileria-specific...
ABSTRACT During evolution, pathogenic bacteria have developed complex interactions with their hosts. This has frequently involved the acquisition of virulence factors on pathogenicity islands, plasmids, transposons, or prophages, allowing them to colonize, survive, and replicate within host. In contrast, Mycoplasma species, smallest self-replicating organisms, regressively evolved from gram-positive by reduction genome a minimal size, consequence that they economized genetic resources....
Parasites have evolved a plethora of mechanisms to ensure their propagation and evade antagonistic host responses. The intracellular protozoan parasite Theileria is the only eukaryote known induce uncontrolled cell proliferation. Survival Theileria-transformed leukocytes depends strictly on constitutive nuclear factor kappa B (NF-kappaB) activity. We found that this was mediated by recruitment multisubunit IkappaB kinase (IKK) into large, activated foci surface. IKK signalosome assembly...
The well-established importance of helper T (Th)-cell subsets in immunity and immunoregulation many experimental helminth infections prompted a detailed study the cellular immune response against Fasciola hepatica natural bovine host. T-cell lines established from two cattle infected with F. were characterized for expression surface markers proliferative responses adult worm antigen. Parasite-specific contained mixture CD4+, CD8+, gamma/delta T-cell-receptor-bearing cells. However, cell...
Bovine lymphocytes infected with the parasite Theileria parva continuously secrete a growth factor that is essential for their proliferation in vitro and also constitutively express interleukin 2 receptors on surface. Dilution of secreted factor, caused by culturing cells at low density, results retardation culture growth. Human recombinant 2, however, effectively substitutes diluted restoring normal rates allows Theileria-infected to be grown density without use feeder layers. Secretion...
Aeromonas salmonicida subsp. contains a functional type III secretion system that is responsible for the of ADP-ribosylating toxin AexT. In this study, authors identified AopP as second effector protein secreted by system. The aopP gene was detected in both typical and atypical A. isolates found to be encoded on small plasmid approximately 6.4 kb. Sequence analysis indicates member YopJ family proteins, group proteins interfere with mitogen-activated kinase (MAPK) and/or nuclear factor kappa...
Monoclonal antibodies were raised against sporozoites of Theileria parva. One these (MAbD1) neutralized the infectivity for lymphocytes in vitro and cattle vivo. Neutralization seemed to occur by blocking sporozoite entry into cell. MAbD1 four unrelated stocks T. parva, indicating presence a common antigenic determinant which may be important initiating protective immunity.
The protozoan parasite Theileria inhabits the host cell cytoplasm and possesses unique capacity to transform cells it infects, inducing continuous proliferation protection against apoptosis. transforming schizont is a multinucleated syncytium that resides free in strictly intracellular. To maintain transformation, crucial this divided over two daughter at each cytokinesis. This process was dissected using different cycle synchronization methods combination with targeted application of...
Parasites have evolved a plethora of strategies to ensure their survival. The intracellular parasite Theileria parva secures its propagation and spreads through the infected animal by infecting transforming T cells, inducing continuous proliferation rendering them metastatic. In previous work, we shown that induces constitutive activation transcription factor NF-κB, degradation cytoplasmic inhibitors. biological significance NF-κB in T. -infected however, has not yet been defined. Cells...
When T cells become infected by the parasite Theileria parva, they acquire a transformed phenotype and no longer require antigen-specific stimulation or exogenous growth factors. This is accompanied constitutive interleukin 2 (IL-2) IL-2 receptor expression. Transformation can be reversed entirely elimination of parasites using specific drug BW720c. Extracellular signal-regulated kinase jun NH2-terminal (JNK) are members mitogen-activated protein family, which play central role in regulation...
The intracellular protozoan parasite Theileria parva causes a lymphoproliferative disease of T cells in cattle and uncontrolled lymphocyte proliferation culture. We have identified characterized infected the transcriptional activator, NF-kappa B, whose recognition motifs been several gene enhancers important for lymphocyte-specific expression. B is normally constitutively activated nuclear extracts derived from can be induced nonlymphoid by phorbol esters. Theileria-infected lymphocytes...
The apicomplexan parasite Theileria annulata transforms infected host cells, inducing uncontrolled proliferation and clonal expansion of the parasitized cell population. Shortly after sporozoite entry into target cell, surrounding membrane is dissolved an array microtubules (MTs) surrounds parasite, which develops transforming schizont. latter does not egress to invade transform other cells. Instead, it remains tethered MTs and, during mitosis cytokinesis, engages cell's astral central...