A5101703190- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Cell death mechanisms and regulation
- Electrospun Nanofibers in Biomedical Applications
- Lipid metabolism and biosynthesis
- Phagocytosis and Immune Regulation
- Metabolism and Genetic Disorders
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Photosynthetic Processes and Mechanisms
- Brucella: diagnosis, epidemiology, treatment
- Tannin, Tannase and Anticancer Activities
- Innovations in Medical Education
- 3D Printing in Biomedical Research
- Innovative Teaching Methods
- DNA Repair Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Health Sciences Research and Education
- Lipid Membrane Structure and Behavior
- Ion Transport and Channel Regulation
- Cellular transport and secretion
- Medicinal Plant Research
- Cardiac Ischemia and Reperfusion
- Pancreatitis Pathology and Treatment
- Renal function and acid-base balance
California Northstate University
2019-2024
Christian Medical College
2020
Christian Medical College & Hospital
2020
Pacific University Oregon
2014-2018
Pacific University
2015-2017
New York University
2006-2015
Seton Hall University
2011
NYU Langone Health
2007-2010
All India Institute of Medical Sciences
2008
Indiana University School of Medicine
2007
Tafazzin is a putative enzyme that involved in cardiolipin metabolism, it may carry mutations responsible for Barth syndrome. To identify the biochemical reaction catalyzed by tafazzin, we expressed full-length isoform of Drosophila melanogaster tafazzin baculovirus-Sf9 insect cell system. expression induced new enzymatic function Sf9 mitochondria, namely 1-palmitoyl-2-[14C]linoleoyl-phosphatidylcholine:monolysocardiolipin linoleoyltransferase. We also found evidence reverse reaction,...
Quantitative and qualitative alterations of mitochondrial cardiolipin have been implicated in the pathogenesis Barth syndrome, an X-linked cardioskeletal myopathy caused by a deficiency tafazzin, enzyme remodeling pathway. We generated previously reported tafazzin-deficient Drosophila model syndrome that is characterized low concentration, abnormal fatty acyl composition, mitochondria, poor motor function. Here, we first show tafazzin disrupts final stage spermatogenesis, spermatid...
Acetaminophen (APAP) overdose is one of the most frequent causes acute liver failure in United States and primarily mediated by toxic metabolites that accumulate upon depletion glutathione stores. However, cells innate immune system, including natural killer (NK) cells, neutrophils, Kupffer have also been implicated centrilobular necrosis associated with APAP. We recently shown dendritic (DCs) regulate intrahepatic inflammation chronic disease and, therefore, postulated DC may modulate...
The tafazzin gene encodes a phospholipid-lysophospholipid transacylase involved in cardiolipin metabolism, but it is not known why forms multiple transcripts as result of alternative splicing. Here we studied the intracellular localization, enzymatic activity, and metabolic function four isoforms human three Drosophila upon expression different mammalian insect systems. When expressed HeLa cells, all were localized mitochondria except for B-form tafazzin, which was associated with membranes....
Journal Article Biodosimetry using chromosome aberrations in human lymphocytes Get access S. Senthamizhchelvan, Senthamizhchelvan *Corresponding author: gspant@rediffmail.com Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Pant, Pant K. Rath, Rath P. Julka, Julka O. Nair, Nair R. C. Joshi, Joshi A. Malhotra, Malhotra M. Pandey Radiation Protection Dosimetry, Volume 123, Issue 2, February 2007, Pages 241–245, https://doi.org/10.1093/rpd/ncl109 Published: 05...
Objective. To develop and evaluate the effectiveness of a structured model for reflective journal writing (RJW) grading rubric as part student portfolio designed to help Doctor Pharmacy (PharmD) students create actionable goals. Methods. A structured, eight-domain format was developed engage in prioritization, identification, exploration, recollection, evaluation, challenging/solidifying their own knowledge, while assembling an action plan development (abbreviated using acronym PIE-RECAP)....
Hearts of rats made hypertensive (BP greater than 150 mmHg) by left renal artery clipping and sham operated controls were studied in two series experiments. In I, cardiac function was an isolated working heart apparatus at weeks 4, 9 to 10 16 17 post-surgery. II, coronary flow during normoxic anoxic retrograde perfusions days 6 4 when compared with controls, hypertensives had lower body weights 10, higher ventricular each period. Heart depressed for as measured stroke volume, peak systolic...
Piperine is an attractive therapeutic alkaloid from black pepper that exhibits a broad spectrum of pharmacological properties over various pathological disorders including cancer. Voltage-gated K+ channels (KV) play important role in regulating cancer cell proliferation and are considered as potential targets for the treatment However, there paucity information with regard to implication piperine KV associated anticancer activities on human prostate cells LNCaP PC-3 cells. Therefore, primary...
The objective of this review is to provide the conclusions from American Association Colleges Pharmacy (AACP) Council Deans (COD) Taskforce on Research and Scholarship.
The objective of this study was to estimate equivalent whole body dose and the irradiated region in hemi-body irradiation cancer patients using chromosome aberrations micronuclei techniques. frequency unstable studied peripheral blood lymphocytes before after irradiation. mean estimated 3.74 ± 0.16 Gy 4.07 0.15 from dicentrics be 6.85 0.2 6.79 0.26 Dolphin's contaminated Poisson dispersion analysis Qdr method, respectively. 7.04 0.25 by method. There a slight underestimation part vivo....
Study objective – The aim was to determine whether surviving myocardium in the infarcted rat heart retains ability respond sustained increases afterload. Design Cardiac mass, ventricular function, and actomyosin ATPase activity were compared animals subjected coronary artery ligation produce infarction, superimposed renal constriction 4 weeks after sham operated animals. Experimental material Female Wistar rats obtained at 10 of age (200-225 g) used for studies. Measurements main results...
Air pollution remains one of the most formidable environmental threats to human health globally, particularly in urban areas, contributing nearly 7 million premature deaths annually. Megacities, defined as cities with populations exceeding 10 million, are frequent hotspots severe pollution, experiencing numerous weeks dangerously poor air quality due concentration harmful pollutants. In addition, complex interplay factors makes accurate predictions incredibly challenging, and prediction...