A5056153725- Angiogenesis and VEGF in Cancer
- SARS-CoV-2 and COVID-19 Research
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- Protein Kinase Regulation and GTPase Signaling
- Protease and Inhibitor Mechanisms
- Lymphatic System and Diseases
- Cancer Cells and Metastasis
- Animal Virus Infections Studies
- Technology Adoption and User Behaviour
- Blood Coagulation and Thrombosis Mechanisms
- Cellular Mechanics and Interactions
- Biomarkers in Disease Mechanisms
- Antifungal resistance and susceptibility
- COVID-19 Impact on Reproduction
- Cerebrovascular and genetic disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Kawasaki Disease and Coronary Complications
- Indian Economic and Social Development
- Stochastic Gradient Optimization Techniques
- Global trade and economics
- Enzyme function and inhibition
- Amino Acid Enzymes and Metabolism
- Immunodeficiency and Autoimmune Disorders
Texas Tech University Health Sciences Center
2017-2023
Texas Tech University
2017-2023
Center for Biologics Evaluation and Research
2022
United States Food and Drug Administration
2022
University of Dhaka
2019-2022
Khulna University of Engineering and Technology
2020
Neutralization capacity of antibodies against Omicron after a prior SARS-CoV-2 infection in children and adolescents is not well studied. Therefore, we evaluated virus-neutralizing Alpha, Beta, Gamma, Delta variants by age-stratified analyses (<5, 5-11, 12-21 years) 177 pediatric patients hospitalized with severe acute COVID-19, MIS-C, convalescent samples outpatients mild COVID-19 during 2020 early 2021. Across all patients, less than 10% show neutralizing antibody titers Omicron. Children...
People’s acceptance of technological changes has escalated with time. However, the and adoption fintech services hiked after outbreak virulent coronavirus. With this breakout, mobile (MFS) increased among general citizens business sectors around world, including in developed, emerging, developing economies. This study aimed to identify factors that impact intention consumers embrace enhance use an emerging market, Bangladesh. A research model was developed strengthen objective paper. total...
There is limited knowledge on durability of neutralization capacity and antibody affinity maturation generated following two versus three doses SARS-CoV-2 mRNA vaccines in naïve convalescent individuals (hybrid immunity) against the highly transmissible Omicron BA.1, BA.2 BA.3 subvariants. Virus titers vaccine-homologous strain (WA1) sublineages are measured a pseudovirus assay (PsVNA). In addition, binding spike proteins from WA1, determined using surface plasmon resonance (SPR). The who...
Abstract Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene expression. Among the GTPases, RhoA, Rac1 Cdc42 are best characterized. The role endothelial in embryonic development retinal has been studied, however RhoA yet to be explored. Here, we aimed identify functions, explored compensatory mechanisms. In vitro , involved...
Glucose is an important source of energy for the central nervous system. Its uptake at blood-brain barrier (BBB) mostly mediated via glucose transporter 1 (GLUT1), a facilitated encoded by SLC2A1 gene. GLUT1 Deficiency Syndrome (GLUT1DS) haploinsufficiency characterized mutations in gene, resulting impaired BBB and clinically epileptic seizures movement disorder. A major limitation absence vitro models reproducing disease. This study aimed to characterize model GLUT1DS using human...
Metastasis is considered a major burden in cancer, being responsible for more than 90% of cancer-related deaths. Tumor angiogenesis one the main processes that lead to tumor metastasis. Penfluridol classic and commonly used antipsychotic drug, which has great ability cross blood–brain barrier. Recent studies have revealed penfluridol significant anti-cancer activity diverse tumors, such as metastatic breast cancer glioblastoma. Here, we aim identify effect low doses on microenvironment...
Abstract This study aims to identify pathway involvement in the development of cisplatin (cis-diamminedichloroplatinum (II); CDDP) resistance A549 lung cancer (LC) cells by utilizing advanced bioinformatics software. We developed CDDP-resistant (A549/DDP) through prolonged incubation with drug and performed RNA-seq on RNA extracts determine differential mRNA miRNA expression between A549/DDP cells. analyzed gene dysregulation Ingenuity Pathway Analysis (IPA; QIAGEN) In contrast prior...
Abstract/Summary The endothelial barrier plays an active role in transendothelial tumor cell migration during metastasis, however, the regulatory elements of this step remain obscure. Here we show that RhoA activation is a determining factor process. Breast cell-induced combined outcome paracrine IL-8-dependent and cell-to-cell contact β 1 integrin-mediated mechanisms, with pathway correlating clinical data. Endothelial-specific blockade or vivo deficiency inhibited metastatic potential...
In deep learning, the optimization techniques are most part dependent on gradient descent methods, such as SGD, Adam; adopt leading place in area of methods. Conventional methodologies which depend stochastic gradients non-adaptive because prescribed parameter worth's usage should be tuned for every application. However, generalization performance optimizers is far superior to adaptive whereas Adam and its variants cannot maintain this without a fast convergence rate neural networks. To...