A5041061791- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nuclear Physics and Applications
- Plasma Applications and Diagnostics
- Cell Adhesion Molecules Research
- Renal cell carcinoma treatment
- Nuclear reactor physics and engineering
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- NF-κB Signaling Pathways
- Liver Disease Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Monoclonal and Polyclonal Antibodies Research
- Plasma Diagnostics and Applications
- Cancer Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- HIV Research and Treatment
- Management of metastatic bone disease
- Pleural and Pulmonary Diseases
- Soft tissue tumor case studies
- Cellular Mechanics and Interactions
- Immunotherapy and Immune Responses
Nagoya City University
2012-2024
Tokushima Hospital
2020
Okayama University
2010-2019
Massachusetts Institute of Technology
2018-2019
Okayama University Hospital
2006-2019
University of Arizona
2019
Cornell University
2019
University of Tokyo Hospital
2016
Onomichi General Hospital
2014
Japan Women's University
2011
Changes in 7 antioxidative enzymes naturally senescent cotyledons of cucumber ( Cucumis sativus ) were investigated. The activities superoxide dismutase (SOD; EC 1.15.1.1), catalase (EC 1.11.1.6), dehydroascorbate reductase 1.8.5.1) and glutathione (GR; 1.6.4.2) gradually decreased during the progression senescence, while those ascorbate peroxidase (APX; 1.11.1.11) guaiacol (GPX; 1.11.1.7) increased. activity monodehydroascorbate (MDAR; 1.6.5.4) was not significantly changed. Western blot...
Class II major histocompatibility (class II) genes are regulated in a B-cell-specific and gamma interferon-inducible fashion. The master switch for the expression of these is class transactivator (CIITA). In this report, we demonstrate that one functions CIITA to recruit CREB binding protein (CBP) promoters. Not only functional but also specific interactions between CBP were demonstrated. Moreover, dominant negative form decreased activity promoters levels determinants on surface cells....
In Saccharomyces cerevisiae, 3-amino-1,2,4-triazole (aminotriazole) competitively inhibits the activity of imidazoleglycerolphosphate dehydratase, product HIS3 gene. Wild-type strains are able to grow in presence 10 mM aminotriazole because they induce level dehydratase. However, containing gcn4 mutations unable medium lack GCN4 transcriptional activator protein necessary for coordinate induction and other amino acid biosynthetic genes. Here, we isolated a new gene, designated ATR1, which...
Erythropoietin (Epo) is a glycoprotein factor that specifically regulates the proliferation and differentiation of erythroid progenitor cells. Here we describe isolation Epo-responsive mouse erythroleukemia cell line SKT6, characterization specific binding biologically active 125I-labeled human Epo (125I-Epo) to its membrane receptor, and, finally, report information concerning molecular structure receptor. About 75% colony-forming precursor cell-like colonies derived from SKT6 cells were...
The persistence of human immunodeficiency virus (HIV) in optimally treated infected individuals poses a major therapeutic problem. In latently cells, one the observed phenotypes is absent elongation viral transcription. Thus, positive factor b (P-TEFb), which usually recruited by NF-kappaB or Tat, not present on HIV long terminal repeat (LTR). Although most attempts to activate these proviruses centered NF-kappaB, we investigated effects Tat. To this end, generated transgenic mice, secreted...
The pulsed streamer discharge was generated in the liquid by using point-to-sphere electrode geometry. In this study, OH radicals were measured indirectly a chemical dosimetry. Terephthalic acid (TA) used as an radical scavenger and fluorescence of resulted 2-hydroxyterephthalic (HTA) measured. Instead use conventional spectrophotometer, novel observing system light-emitting diode (LED) light source simplified spectrometer detector developed. As result, intensity increased with time elapsed...
It has been shown that hyperthermia can enhance the cytotoxicity of some chemotherapeutics. However, most effective agent(s) at elevated temperatures have yet to be determined. A previous study suggests drug choice may different from physiological temperature, and alkylating agents temperatures. To further investigate these possibilities, effect chemotherapeutic were compared. These cyclophosphamide, ifosfamide, melphalan, cis-diamminedichloroplatinum (II), 5-fluorouracil, mitomycin C...
The purpose of this study was to compare the clinical outcomes induction chemoradiotherapy and chemotherapy identify prognostic factors for non-small-cell lung cancer patients with mediastinal lymph node metastasis who were treated therapy. Between August 1995 December 2010, 50 pathological scheduled receive therapy followed by surgery. Irinotecan plus cisplatin used from June April 1999, docetaxel concurrent radiation at a dose 40–46 Gy has been since May 1999. Thirty-five 15 chemotherapy....
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is relevant for the prognosis in patients with RA. Nintedanib, which inhibits both receptor and non-receptor type tyrosine kinases, an antifibrotic drug treatment of progressive fibrosing ILDs, such as idiopathic pulmonary fibrosis systemic sclerosis-associated disease. Little known about effects nintedanib on RA-ILD. We examined characteristics a novel induced RA-ILD (iRA-ILD) mouse model model. D1CC×D1BC mice are highly...
Using a new system developed by us for acquiring microscopic images automatically, we compared the morphological changes that apoptotic cells undergo with in staining pattern of annexin V-enhanced green fluorescent protein (AV-EGFP) and propidium iodide (PI) individual cells. Jurkat were treated 5 mM CaCl2 alone, anti-Fas antibody heating at 42 degrees C 30 min or 46 60 min, then incubated medium CaCl2. Time-lapse DNA fragmentation analysis observation revealed induced typical apoptosis...
The p53 binding protein 2 (53BP2) has been identified as the interacting to p53, Bcl‐2, and p65 subunit of nuclear factor κB (NF‐κB). TP53BP2 gene encodes two splicing variants, 53BP2S 53BP2L, previously known apoptosis stimulating (ASPP2). We found that these 53BP2 proteins are located predominantly in cytoplasm induce demonstrated by cleavage poly ADP ribose polymerase (PARP) annexin V staining. Furthermore, we demonstrate is mitochondria induces associated with depression mitochondrial...
Genetic susceptibility to rheumatoid arthritis (RA) is associated with certain MHC class II molecules. To clarify the role of these determinants in RA, we generated D1CC transgenic mouse that expressed genes involved antigen processing and presentation by pathway joints. The transactivator, which was transcribed from rat collagen type promoter enhancer, directed expression genes. In mice congenic for H-2(q) (DBA/1) background, small amounts bovine adjuvant induced reproducibly an...