A5035135814- HIV Research and Treatment
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Immune responses and vaccinations
- Virology and Viral Diseases
- Viral-associated cancers and disorders
- Immune Response and Inflammation
- Genetic Neurodegenerative Diseases
- Immunotherapy and Immune Responses
- Fungal and yeast genetics research
- HIV/AIDS Research and Interventions
- Cytomegalovirus and herpesvirus research
- IL-33, ST2, and ILC Pathways
- Lymphoma Diagnosis and Treatment
- DNA Repair Mechanisms
- Blood groups and transfusion
- Herpesvirus Infections and Treatments
Duke University
2024
University of North Carolina at Chapel Hill
2016-2022
Tufts University
2011
Spinocerebellar ataxia 10 (SCA10) is an autosomal dominant disease caused by large-scale expansions of the (ATTCT)(n) repeat within intron human ATXN10 gene. In contrast to other expandable repeats, this pentanucleotide does not form stable intra- or interstranded DNA structures, being a unwinding element instead. We analyzed instability in yeast experimental system, where its led inactivation URA3 reporter The was due dramatic decrease mRNA levels owing premature transcription termination...
Latency is the defining characteristic of Herpesviridae and central to tumorigenesis phenotype Kaposi’s sarcoma-associated herpesvirus (KSHV). KSHV-driven primary effusion lymphomas (PEL) rapidly develop resistance therapy, suggesting tumor instability plasticity.
Most infant deaths occur in the first year of life. Yet, our knowledge immune development during this period is scarce, and derived from cord blood only. To more effectively combat pediatric diseases, a deeper understanding kinetics factors that regulate maturation functions early life needed. Increased disease susceptibility infants generally attributed to T helper 2 (Th2)- biased responses. The differentiation CD4+ cells along specific Th cell lineage dependent on pathogen type,...
The HIV epidemics in infants and adolescent women are linked. Young of childbearing age at high risk for infection and, due to poor testing rates low adherence antiretroviral therapy, mother-to-infant transmission. We hypothesize that vaccine regimens initiated early life would provide the necessary time frame induce mature highly functional Env-specific antibody responses could potentially also protect against acquisition later life. present study was designed test two regimens, a clade C...
ABSTRACT Nonhuman primate (NHP) models are invaluable for HIV pathogenesis, intervention and cure studies. To enhance the translational potential of NHP vaccine studies, clinically relevant R5-tropic, tier 2 neutralization sensitive, mucosally transmissible simian-human immunodeficiency viruses (SHIVs) have been designed. Towards our goal developing vaccines to prevent breastmilk transmission HIV, we evaluated virological outcomes three distinct SHIVs in repeated weekly oral exposure...
The details of the pediatric immune system that supports induction antibodies capable neutralizing geographically-diverse or heterologous HIV-1 is currently unclear. Here we explore environment in neonatal macaque undergoing Simian-HIV infection. infection 11 pairs therapy-naive dams and infant rhesus macaques for 24 months results 64% young compared to 18% adult macaques. Heterologous emerge by 12 post-infection macaques, association with lower expression immunosuppressive genes, fewer...
Abstract In 2014, an estimated 220,000 children became newly HIV-infected, with 50% being transmitted via breast-feeding. The present study assessed whether inclusion of oral route immunization would increase pediatric vaccine efficacy in the rhesus macaque model SIV infection. Two groups 6 neonatal macaques received 2 DNA-SIV immunizations at weeks 0 and 3, followed by boosts modified vaccinia Ankara virus (MVA)-SIVgag/pol/env 9. Group A was immunized intramuscular (IM) route. Infants B...
Abstract Natural Killer (NK) cells are an important component of the innate immune system, capable providing a fast and effective response against virally infected cells. NK mainly characterized by their cytotoxic function ability to secrete cytokines. It has been shown that infant have decreased cytotoxicity cytokine-secreting function, suggesting hyporesponsiveness during first year life. Because cell activation is dependent on cytokine stimulation, we hypothesized hyporesponsive due...