A5064773060- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Kruppel-like factors research
- Immune Response and Inflammation
- Immune cells in cancer
- Cancer-related gene regulation
- Genetic Syndromes and Imprinting
- Immune responses and vaccinations
- Hematopoietic Stem Cell Transplantation
- FOXO transcription factor regulation
- Sepsis Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Galectins and Cancer Biology
- Platelet Disorders and Treatments
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Autoimmune and Inflammatory Disorders
- IL-33, ST2, and ILC Pathways
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Immunodeficiency and Autoimmune Disorders
- Psoriasis: Treatment and Pathogenesis
- Toxoplasma gondii Research Studies
- Cell Adhesion Molecules Research
University of Minnesota
2009-2025
St. Luke's Hospital
2023-2025
University of Minnesota Medical Center
2007-2015
National Institute of Allergy and Infectious Diseases
2010-2011
National Institutes of Health
2008-2011
Abstract Nonlymphoid T cell populations control local infections and contribute to inflammatory diseases, thus driving efforts understand the regulation of their migration, differentiation, maintenance. Numerous observations indicate that trafficking differentiation within lung are starkly different from what has been described in most nonlymphoid tissues, including intestine skin. After systemic infection, we found >95% memory CD8 cells isolated mouse via standard methods were...
Ig class switch recombination (CSR) and somatic hypermutation serve to diversify antibody responses are orchestrated by the activity of activation-induced cytidine deaminase many proteins involved in DNA repair genome surveillance. Msh5, a gene encoded central MHC III region, its obligate heterodimerization partner Msh4 have critical role regulating meiotic homologous not been implicated CSR. Here, we show that MRL/lpr mice carrying congenic H-2(b/b) interval exhibit several abnormalities...
Proteasomes are multisubunit proteases that initiate degradation of many Ags presented by MHC class I molecules. Vertebrates express alternate forms each the three catalytic proteasome subunits: standard subunits, and immunosubunits, which constitutively expressed APCs induced in other cell types exposure to cytokines. The assembly mixed proteasomes containing subunits immunosubunits is regulated a tissue specific manner. In this study, we report presence immune cells LMP2(-/-) mice...
Naive antiviral CD8+ T cells are activated in the draining LN (DLN) by dendritic (DCs) presenting viral antigens. However, many viruses infect macrophages, which participate initiation of innate immunity and B cell activation. To better understand how why select infected DCs rather than we performed intravital microscopy ex vivo analyses after infecting mice with vaccinia virus (VV), a large DNA that infects both macrophages DCs. Although interact peripheral interfollicular region (PIR),...
Both common and rare genetic variants of laccase domain-containing 1 (LACC1, previously C13orf31) are associated with inflammatory bowel disease, leprosy, Behcet systemic juvenile idiopathic arthritis. However, the functional relevance these is unclear. In this study, we use LACC1-deficient mice to gain insight into role LACC1 in regulating inflammation. Following oral administration Citrobacter rodentium, knockout (KO) had more severe colon lesions compared wildtype (WT) controls....
Uropathogenic
Successful vaccination strategies offer the potential for lifelong immunity against infectious diseases and cancer. There has been increased attention regarding limited translation of some preclinical findings generated using specific pathogen-free (SPF) laboratory mice to humans. One reason difference between clinical lies in maturation status immune system at time challenge. In this study, we used a "dirty" mouse model, where SPF were cohoused (CoH) with pet store permit microbe transfer...
Abstract Thus far, CD8 T cell responses to respiratory infections have been restricted broad tissue analyses, which may not accurately represent the true nature of tissue, nor response infection. In order thoroughly explore dynamics response, we used and systemic infection models perform a detailed analysis anatomic location, phenotype, migration capacity, longevity CD8s in lung. Interestingly, found that as many 98% cells would commonly be perceived were actually capillaries. We show...
Abstract Memory T cells, unlike naïve have the capacity to traffic and be retained in non-lymphoid tissue (NLT). Because most infections originate NLT early detection of pathogens can lead a more effective immune response, identifying factors contributing memory cell residence is an important aspect potential. The transcription factor kruppel-like 2 (KLF2) controls naive trafficking (primarily through inducing sphingosine 1 phosphate receptor (S1Pr1)), yet KLF2 expression cells has not been...