A5103148746- Wound Healing and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Electrospun Nanofibers in Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Nerve injury and regeneration
- Neuroblastoma Research and Treatments
- Autoimmune Neurological Disorders and Treatments
- Hydrogels: synthesis, properties, applications
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Magnesium in Health and Disease
- Drug-Induced Ocular Toxicity
- Genetic Neurodegenerative Diseases
- Inhalation and Respiratory Drug Delivery
- Inflammasome and immune disorders
- Vascular Malformations Diagnosis and Treatment
- Soft tissue tumor case studies
- Plant Surface Properties and Treatments
- Respiratory viral infections research
- Membrane-based Ion Separation Techniques
First Affiliated Hospital of Zhengzhou University
2023-2025
Hubei University of Medicine
2024
Taihe Hospital
2024
Hong Kong Polytechnic University
2024
Nantong University
2019-2024
Guangdong Province Women and Children Hospital
2022-2023
Southern Medical University
2021
Nanfang Hospital
2021
Donghua University
2015-2020
China-Japan Friendship Hospital
2018-2019
The development of self-healing conductive hydrogels is critical in electroactive nerve tissue engineering. Typical materials such as polypyrrole (PPy) are commonly used to fabricate artificial conduits. Moreover, the field engineering has advanced toward use products hyaluronic acid (HA) hydrogels. Although HA-modified PPy films prepared for various biological applications, cell-matrix interaction mechanisms remain poorly understood; furthermore, there no reports on PPy-injectable...
Developing multifunctional self-healing hydrogels as wound dressings, including strong tissue adhesion, spray film-forming ability, and excellent bioactivity, are highly desired for full-thickness skin healing applications. In this study, chondroitin sulfate (CSA) was firstly oxidized to aldehyde-based (OHC-CSA), then dopamine (DA) grafted onto OHC-CSA form OHC-CSA-DA. Thereafter, the OHC-CSA-DA carboxymethyl chitosan (COOH-CS) based hydrogel (CSA-DA-CS) successfully fabricated through...
Citric modified chitosan (CC) hydrogel containing antibacterial drugs is developed by the freezing and thawing treatment method. The SEM image of CC revealed a porous structure. rheological properties, porosity, swelling rate, water uptake, tensile properties in vitro degradation were found to be tunable via concentration. To enhance tetracycline hydrochloride (TH) representing drug model, was integrated into hydrogel. cumulative release also loaded showed enhanced antimicrobial activity...
Interleukin (IL)-25 is shown to potentiate type-2 immunity and contribute chronic airway inflammation remodeling in allergic diseases. However, the role of IL-25 idiopathic pulmonary fibrosis (IPF), dominated by nonatopic immunity, still remains largely unclear. Herein, we detected expression levels IL-17BR (IL-25’s receptor) using lung tissue samples gained from IPF patients normal subjects. Also, directly intranasal (IN) instillation mice, examined potential roles mechanisms development...
In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, but-3-yn-2-one base on Schiff thiol-alkynone double cross-links. The structure properties of the were characterized by scanning electron microscope, Fourier-transform infrared, rheological test, followed in vivo biocompatibility tests. results showed that exhibited good self-healing, mechanical properties,...
In this study, an antibacterial and shape-memory chitosan cryogel with high blood absorption fast recovery from non-compressible wounds was prepared using a one-step method. Herein, we shape-memory-reduced graphene/chitosan (rGO-CTS) method frozen mixing solution of chitosan, citric acid, dopamine, graphene oxide, before treating it alkaline solutions. The not only promoted the double cross-linking but also induced dopamine to form polydopamine-reducing oxide. Scanning electron microscope...
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by variable progression. The prealbumin (PA) parameter in routine blood biochemistry examination. We sought to investigate the prognostic value IPF patients.To evaluate prognosis patients with IPF.Blood examination, demographics, function data from consulted Beijing Chao-Yang Hospital and China-Japan Friendship between July 2012 December 2016 were collected. Infection, liver kidney dysfunction...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by scarring and excessive extracellular matrix depositon. When stimulated, alveolar epithelial cells (AECs) are aberrantly activated, the expression of profibrotic molecules enhanced, promoted, but mechanism for this unclear. It has been reported that downregulation Na,K‑ATPase β1 subunit in renal involved development, role protein remains unknown. In present study, was revealed to be...
For pediatric patients with solid abdominal tumors, early diagnosis can guide clinical treatment decisions, and comprehensive preoperative evaluation is essential to reduce surgical risk. The aim of this study was explore the feasibility multiphase enhanced CT-based transformer in tumors prediction risk events (SRE).
Bone cancer pain (BCP) is a common clinical problem in patients. The plasticity of excitatory neurons within the spinal dorsal horn plays significant role development BCP. This study explored roles absent melanoma 2 (AIM2) and stimulator interferon gene (STING) BCP using male C57BL/6J mice. Cancers cells were cultured implanted into tibia to induce pain-like behavior. AIM2-RNAi lentivirus was injected or STING agonist intraperitoneally. protein expressions localization evaluated by qRT-PCR...
Four seasonal coronaviruses, including human coronavirus (HCoV)-229E and HCoV-OC43, HCoV-NL63, HCoV-HKU1 cause approximately 15-30% of common colds in adults. However, the full landscape immune trajectory to these viruses that covers whole childhood period is still not well understood.We evaluated serological responses against four coronaviruses 1886 children aged under 18 years by using enzyme-linked immunosorbent assay. The optical density values each HCoV were determined from sample....
Abstract Background The Rho GTPase-activating protein 26 (ARHGAP26) antibody, or anti-Ca, was recently identified as a subacute cerebellar ataxia autoantibody. Medulloblastoma is the most malignant brain tumor in children, with G4 medulloblastoma being common subgroup. Ten cases involving ARHGAP26 autoantibody-associated autoimmune (ACA) have been reported to date, an age of onset 24 84 years. Five patients had history tumors. However, there no case ACA coexisting medulloblastoma. Case...
Abstract Purpose Pediatric acute myeloid leukemia (AML) is associated with a dismal prognosis, underscoring the urgent need to identify potential biomarkers that can aid in management of pediatric AML patients. Methods The adult dataset GSE201492 was partitioned into distinct prognostic groups following identification key genes through screening differentially expressed genes, enrichment analysis, and protein-protein interaction (PPI) analysis. Subsequently, these were validated obtained...
Abstract Background The Rho GTPase-activating protein 26 (ARHGAP26) antibody, or anti-Ca, was recently identified as a subacute cerebellar ataxia autoantibody. Medulloblastoma is the most malignant brain tumor in children, with G4 medulloblastoma being common subgroup. Ten cases involving ARHGAP26 autoantibody-associated autoimmune (ACA) have been reported to date, an age of onset 24 84 years. Five patients had history tumors. However, there no case ACA coexisting medulloblastoma. Case...