A5005402087- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Echinoderm biology and ecology
- Marine Bivalve and Aquaculture Studies
- Viral Infections and Immunology Research
- interferon and immune responses
- MicroRNA in disease regulation
- Ocean Acidification Effects and Responses
- Coral and Marine Ecosystems Studies
- Mosquito-borne diseases and control
- Ubiquitin and proteasome pathways
- Genetic Associations and Epidemiology
- Glycosylation and Glycoproteins Research
- Protein Degradation and Inhibitors
- Virology and Viral Diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Herpesvirus Infections and Treatments
- Circular RNAs in diseases
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
Dalian Ocean University
2021-2025
Peking University
2025
Chinese Academy of Agricultural Sciences
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Shanxi Medical University
2023-2024
Jilin University
2019-2024
Shaanxi Provincial People's Hospital
2024
Shanxi Academy of Medical Sciences
2023-2024
Ministry of Agriculture and Rural Affairs
2021-2023
ZheJiang Academy of Agricultural Sciences
2022
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has a global health crisis; its structural protein envelope (E) is critical for viral entry, budding, production, and induction of pathology which makes it potential target therapeutics against COVID-19. Here, we find that the E3 ligase RNF5 interacts with catalyzes ubiquitination E on 63rd lysine, leading to degradation ubiquitin-proteasome system (UPS). Importantly,...
Enveloped viruses encased within a lipid bilayer membrane are highly contagious and can cause many infectious diseases like influenza COVID-19, thus calling for effective prevention inactivation strategies. Here, we develop diatomic iron nanozyme with lipoxidase-like (LOX-like) activity the of enveloped virus. The sites destruct viral envelope via peroxidation, displaying non-specific virucidal property. In contrast, natural LOX exhibits low antiviral performance, manifesting advantage over...
The cellular biological function of the ubiquitin-proteasome pathway as an important modulator for regulation many fundamental processes has been greatly appreciated. critical role in viral pathogenesis become increasingly apparent. It is a powerful tool that host cells use to defend against infection. Some proteins can restriction factors limit infection by ubiquitin-dependent degradation. In this research, we identificated CUL4B-DDB1-PRPF19 E3 Ubiquitin Ligase Complex mediate proteasomal...
SARS-CoV-2, the causative agent of COVID-19 pandemic, undergoes continuous evolution, highlighting an urgent need for development novel antiviral therapies. Here we show a quantitative mass spectrometry-based succinylproteomics analysis SARS-CoV-2 infection in Caco-2 cells, revealing dramatic reshape succinylation on host and viral proteins. promotes several key enzymes TCA, leading to inhibition cellular metabolic pathways. We demonstrated that protein is regulated by nonstructural (NSP14)...
Seed oleic acid is an important quality trait sought in rapeseed breeding programs. Many methods exist to increase seed content, such as the CRISPR/Cas9-mediated genome editing system, yet there no report on content improvement via this system’s precise of double loci BnFAD2 . Here, a encoded (A5 and C5) was established. The results demonstrated high efficiency regeneration transformation, with genotype screened ratios 20.18% 85.46%, respectively. total 64.35%, whereas single locus-...
Immune checkpoint blockade (ICB) has significantly improved the prognosis of patients with cancer, although majority such achieve low response rates; consequently, new therapeutic approaches are urgently needed. The upregulation sialic acid-containing glycans is a common characteristic cancer-related glycosylation, which drives disease progression and immune escape via numerous pathways. Herein, development self-assembled core-shell nanoscale coordination polymer nanoparticles loaded...
The contradiction between the rapid development of breeding scale and relatively backward technology is a bottleneck that has restricted Japanese sea cucumber (Apostichopus japonicus) industry. Finding new way to produce seedlings instead traditional model will be highly significant. Previously, we found ecological seedling produced A. japonicus individuals with red body color. Most artificially bred are green, color not yet been reported for japonicus. Therefore, it particularly important...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne hemorrhagic disease high fatality rate of 10%-20%. Vaccines or specific therapeutic measures remain lacking. Human interferon inducible transmembrane protein 3 (hIFITM3) a broad-spectrum antiviral factor targeting viral entry. However, the activity hIFITM3 against SFTS virus (SFTSV) and functional mechanism IFITM3 remains unclear. Here we demonstrate that endogenous provides protection SFTSV infection participates...
Porcine epidemic diarrhea (PED) and transmissible gastroenteritis (TGE) caused by porcine virus (PEDV) (TGEV) are two highly contagious intestinal diseases in the swine industry worldwide. Notably, coinfection of TGEV PEDV is common piglets with diarrhea-related diseases. In this study, epithelial cells (IPEC-J2) were single or coinfected and/or TGEV, followed comparison differentially expressed genes (DEGs), especially interferon-stimulated (ISGs), between different groups via...
Strongylocentrotus intermedius is one of the most economically valuable sea urchin species in China and has experienced mass mortality owing to outbreaks bacterial diseases such as black mouth disease. This caused serious economic losses farming industry. To investigate immune response mechanism S. with different tube feet colors Vibrio harveyi infection, we examined feet-colored under V. challenge compared their transcriptome microRNA (miRNA) profiles using RNA-Seq. We obtained 1813...
Nipah virus (NiV) is a highly lethal zoonotic with potential large-scale outbreak, which poses great threat to world health and security. In order explore more factors associated NiV, proximity labeling method was applied investigate the F, G, host protein interactions systematically. We screened 1996 1524 high-confidence proteins that interacted NiV fusion (F) glycoprotein attachment (G) in HEK293T cells by technology, 863 of them both F G. The results GO KEGG enrichment analysis showed...
Whether women have a higher risk of adverse events compared with men following coronary angiography (CAG) and percutaneous intervention (PCI) remains controversial. We aimed to investigate the sex differences in characteristics, treatments outcomes among patients undergoing CAG PCI large Chinese cohort.We analyzed and/or this multi-center registry cohort study Cardiorenal ImprovemeNt II (CIN-II) 5 tertiary hospitals from 2007 2020. Clinical treatment (discharge medication PCI) in-hospital...
Abstract Background Apostichopus japonicus is an economically important species in the global aquaculture industry. Russian A. , mainly harvested Vladivostok region, exhibits significant phenotypic differentiation, including many traits, compared with Chinese owing to differences their habitat. However, both genetic basis for divergence and population structure of are unknown. Result In this study, 210 individuals from seven populations were sampled whole-genome resequencing. The analysis...
Porcine deltacoronavirus (PDCoV) is a zoonotic pathogen with global distribution, capable of infecting both pigs and humans. To mitigate the risk cross-species transmission potential outbreaks, it crucial to characterize novel antiviral genes, particularly those from human hosts.
The coronavirus disease 2019 (COVID-19) pandemic has driven major advances in virus research. role of glycans viral infection been revealed, with research demonstrating that terminal sialic acids are key receptors during attachment and into host cells. However, there is an urgent demand for universal tools to study the mechanism infections, as well develop therapeutic agents against epidemic viruses through downregulation acid residues on acting a glyco-virus checkpoint accelerate clearance....
Polyploid breeding is widely used in aquaculture as an important area of new research. We have previously grown Apostichopus japonicus triploids with a growth advantage. The body length, weight, and aestivation time triploid diploid A. were measured this study, the transcriptome metabolome to examine advantage japonicus. results showed that proportion length 6-12 cm 12-18 was significantly higher than japonicus, had shorter (39 days) (63 days). discovered 3296 differentially expressed genes...
Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has posed a constant threat to human beings and the world economy for more than two years. Vaccination is first choice control prevent pandemic. However, an effective SARS-CoV-2 vaccine against virus infection still needed. This study designed prepared four kinds of virus-like particles (VLPs) using insect expression system. Two constructs encoded wild-type spike (S) fused with...