A5042244536- Thyroid Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Cytokine Signaling Pathways and Interactions
- Melanoma and MAPK Pathways
- PI3K/AKT/mTOR signaling in cancer
- Thyroid and Parathyroid Surgery
- Cancer Immunotherapy and Biomarkers
- Child Nutrition and Water Access
- Diabetes and associated disorders
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Diet, Metabolism, and Disease
- Neuroendocrine Tumor Research Advances
- Geriatric Care and Nursing Homes
- Family and Patient Care in Intensive Care Units
- Pituitary Gland Disorders and Treatments
- Cancer Research and Treatments
- Trace Elements in Health
- Diet and metabolism studies
- Mechanical Circulatory Support Devices
- Metabolism, Diabetes, and Cancer
Advocate Christ Medical Center
2021
Johns Hopkins Medicine
2011-2020
Johns Hopkins University
2007-2020
University of Baltimore
2013
The optimal diet to improve glycemia in patients with type 2 diabetes remains unclear. Low carbohydrate, high fat (LCHF) diets can glycemic control, but have not been investigated real-world settings.
We completed a phase I clinical trial to test the safety and toxicity of combined treatment with cixutumumab (anti-IGF-1R antibody) selumetinib (MEK 1/2 inhibitor). Patients advanced solid tumours, refractory standard therapy received hydrogen sulphate capsules orally twice daily, intravenously on days 1 15 each 28-day cycle. The study used 3+3 design, dose-finding cohort followed by an expansion at maximally tolerated dose that included pharmacokinetic pharmacodynamic correlative studies....
Abstract Purpose: Differentiated thyroid cancer (DTC) responds to VEGF receptor inhibitors. signals through RAS/RAF/MEK signaling. We evaluated the safety and efficacy of inhibitor pazopanib MEK trametinib in advanced solid tumors DTC. Patients Methods: with were enrolled a phase I, multicenter trial DTC expansion cohort. received 400–800 mg 1–2 daily. Efficacy cohort was assessed objective response (OR) at 6 months treatment. Results: Twenty-six patients five dose levels. MTD not reached;...
We present a rare case of autoimmune diabetes mellitus and hypothyroidism in an elderly man initiated on nivolumab two months prior to admission for treatment high-grade neuroendocrine rectal tumor. This patient presented local community hospital with one-week history severe nausea, thirst, bilateral leg edema. Biochemical studies confirmed the diagnosis diabetic ketoacidosis setting primary hypothyroidism, likely due use. illustrates acute complication secondary novel anticancer agent....
Abstract Background: P is a small molecule tyrosine kinase inhibitor that selectively inhibits VEGFR1-3, PDGFR-α, PDGFR-β, c-kit, and FGFR 1-3 approved for renal cancer STS. T potent, highly selective, allosteric of MEK1/2 BRAF-mutated advanced melanoma. Increased signaling growth factor receptor kinases have been shown to be important cell survival in multiple tumor types, their inhibition has effective therapeutically STS, DTC, ChCa. In addition, increased RAS/RAF/MEK/ERK plays critical...
TPS3117 Background: Mutations of the RAS/RAF/MEK/ERK signaling pathway, especially RAS, BRAF and IGF-I/II receptor genes play a critical role in development many different types cancers, including breast, colorectal, melanoma, NSCLC, thyroid. Differentiated thyroid cancer (DTC) is most common endocrine malignancy, but there currently no approved therapy for advanced radioiodine-resistant disease. In DTC xenograft models, vertical inhibition this achieved by targeting vascular endothelial...
3020 Background: Significant crosstalk exists between the PI3K and Raf/MEK/ERK pathways treatment of select cell lines with a MEK inhibitor an IGF1-R has been shown to cause greater inhibition growth than either agent alone. IMC-A12 (I) is recombinant human monoclonal antibody directed IGFI-R; it blocks interaction IGF-1R its ligands, IGF-I -II. AZD6244 (A) highly selective, non-competitive ½ inhibitor. Methods: The study phase I, dose-escalation standard 3+3 design. Eligible patients had...
Background: Micronutrient malnutrition is a widespread problem in developing countries. Supplemental zinc has been shown to improve growth undernourished children, but the effect infants or when combined with iron less known. We assessed of low-dose weekly and/or supplementation on among from 6–12 mo age. Methods: Bangladeshi were randomized receive 20 mg (Fe), (Zn), both (Fe + Zn), riboflavin alone Weight and length at baseline, 8, 10, 12 Changes anthropometric indicators compared using...
Abstract Background A multi-specialty approach is required during patient selection for left ventricular assist device (LVAD) implantation. In addition to a comprehensive medical evaluation, patients undergo an extensive psychiatric work up ensure their candidacy when pursuing durable support devices. We aim analyze the impact of illnesses on 2-year outcomes after VAD Methods This study was single center, retrospective analysis 263 who underwent LVAD implantation between 2015 and 2017. All...