A5028716718- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Tuberous Sclerosis Complex Research
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Sarcoidosis and Beryllium Toxicity Research
- Histiocytic Disorders and Treatments
- Occupational and environmental lung diseases
- Vascular Anomalies and Treatments
- Congenital Diaphragmatic Hernia Studies
- Corporate Governance and Law
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Vascular Tumors and Angiosarcomas
- Cardiovascular Issues in Pregnancy
- Neuroscience of respiration and sleep
- Streptococcal Infections and Treatments
- Infectious Diseases and Mycology
- Bacterial Identification and Susceptibility Testing
- Plant and Fungal Interactions Research
- Diphtheria, Corynebacterium, and Tetanus
- Extracellular vesicles in disease
- Neuroblastoma Research and Treatments
Hospices Civils de Lyon
2021-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2025
Hôpital Louis Pradel
2020-2025
Université Claude Bernard Lyon 1
2022-2025
Harvard University
2024-2025
Brigham and Women's Hospital
2025
École Pratique des Hautes Études
2024
Laboratoire National de Référence
2022
Hôpital de la Croix-Rousse
2021
Background: Antibodies against Ku have been described in patients with various connective tissue diseases. The objective of this study was to describe the clinical, functional, and imaging characteristics interstitial lung disease anti-Ku antibodies. Methods: This single-center, retrospective observational conducted at a tertiary referral institution. Patients positive antibodies identified between 2007 2022 were included. Clinical, immunological, data systematically reviewed. Results:...
LAM is a rare multi-cystic lung disease for which treatment with sirolimus indicated in cases of moderate or severe declining function. The aim this study was to describe patients treated and their outcomes. This retrospective observational based on data from the French national health insurance system (SNDS). All adult women receiving were identified France between 2014 2021. In absence specific code system, an algorithm developed identify possible exclusion other indications...
<title>Abstract</title> Pulmonary lymphangioleiomyomatosis (LAM) is metastatic sarcoma but mechanisms of LAM metastasis are unknown. Extracellular vesicles (EV) regulate cancer their roles in have not yet been thoroughly investigated. Here, we report the discovery distinct LAM-EV subtypes derived from primary tumor or metastasizing cells that promote through ITGα6/β1-c-Src-FAK signaling, triggered by shuttling ATP synthesis to cell pseudopodia activation integrin adhesion complex,...
Diffuse interstitial lung diseases (ILD) constitute a heterogeneous group of conditions with complex etiological diagnoses requiring multidisciplinary approach. Much is still unknown about them, particularly their relationship occupational exposures. The primary objective this study was to investigate the distribution exposures according type ILD. secondary objectives were estimate proportion ILDs possibly related exposure and evaluate added value participation an disease consultant in ILD...
Abstract Background and Objective Variants in surfactant genes SFTPC or ABCA3 are responsible for interstitial lung disease (ILD) children adults, with few studies adults. Methods We conducted a multicentre retrospective study of all consecutive adult patients diagnosed ILD associated variants the French rare pulmonary diseases network, OrphaLung. chest computed tomography (CT) features were centrally reviewed. Results included 36 (median age: 34 years, 20 males), 22 group 14 group. Clinical...
Several rare surfactant-related gene (SRG) variants associated with interstitial lung disease are suspected to be cancer, but data missing. We aimed study the epidemiology and phenotype of cancer in an international cohort SRG variant carriers.
Pulmonary alveolar proteinosis (PAP) is characterized by the accumulation of lipoproteins in pulmonary alveoli due to defective clearance macrophages [1]. It may be associated with myriad immune, metabolic, and infectious diseases. In adults, autoimmune PAP anti–granulocyte-macrophage colony stimulating factor (GM-CSF) antibodies. children, hereditary biallelic mutations CSF2RA (MIM 306250) CSF2RB 138981) encoding alpha or beta chains, respectively, GM-CSF receptor. Footnotes This manuscript...
ENTV (Enzootic Nasal Tumor Virus) and JSRV (Jaagsiekte Sheep Retrovirus) are β-retroviruses responsible for respiratory cancers in sheep goats. In this study, we analyzed the genetic features of goat β-Retroviruses (29 24 strains) circulating France to identify molecular signatures associated with disease severity flocks.
Mutations in the Tuberous Sclerosis Complex (TSC) genes result hyperactivation of mechanistic/mammalian target rapamycin 1 (mTORC1) growth pathway mesenchymal pulmonary cells. Rapamycin (Sirolimus
Background. Antibodies against Ku have been described in patients with various connective tissue diseases. The objective of this study was to describe the clinical, functional and imaging characteristics interstitial lung disease anti-Ku antibodies. Methods. This single-center, retrospective observational conducted at a tertiary referral institution. Patients positive antibodies disease, identified between 2007 2022 were included. Clinical, immunological, functional, data systematically...
Background Interstitial lung disease (ILD) is rarer in children (chILD) than adults, but with increasing diagnostic awareness, more cases are being discovered. chILD prognosis often poor, numbers now surviving into adulthood. Aim To characterize chILD-survivors and identify their impact on adult-ILD centers. Methods European study (34 centers) reporting incident/prevalent of from January to July 2023. Epidemiological, clinical, physiological genetic data were collected. Results 244 patients...
<b>Introduction:</b> Mutations in surfactant genes SFTPC or ABCA3 are responsible for interstitial lung disease (ILD) children and adults. Despite numerous paediatric data, few studies described these entities <b>Methods:</b> We conducted a multicenter retrospective study of adult patients with ILD associated mutations the French rare pulmonary diseases network OrphaLung. <b>Results:</b> We included 36 patients, 22 <i>SFTPC</i> group 14 <i>ABCA3</i> group. Clinical...
We report here the case of a 49-year-old man admitted for diagnostic work-up bilateral lung nodules. Empyema rapidly developed after chest computed-tomodensitometry guided puncture. Despite lack obvious aetiology two biopsies, diagnosis was reached by performing 16S ribosomal DNA (rDNA) sequence analysis, which identified Prevotella spp in pleural liquid. The empyema and nodules resolved appropriate antibiotic therapy.