A5031201244- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Colorectal Cancer Screening and Detection
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Surgical Treatments
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Pancreatitis Pathology and Treatment
- Neuropeptides and Animal Physiology
- Radiopharmaceutical Chemistry and Applications
- Inflammatory mediators and NSAID effects
- Receptor Mechanisms and Signaling
- Pneumocystis jirovecii pneumonia detection and treatment
- Lymphoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Immunotherapy and Immune Responses
- Intestinal Malrotation and Obstruction Disorders
Showa University
2016-2025
Showa University Hospital
2024
Dalian Medical University
2022
National Cancer Center Hospital East
2022
Soochow University
2022
First Affiliated Hospital of Soochow University
2022
Immediate bleeding after cold snare polypectomy (CSP) for colorectal polyps might interfere with confirmation of residuals and prolong the time required resection. We investigated whether submucosal epinephrine-added saline injection reduces CSP procedure.We conducted a single-center, prospective, randomized controlled trial (clinical registration number: UMIN000046770). Patients ≤ 10 mm were randomly allocated to either (CEMR group) or conventional (CSP group). The primary outcome was...
Background Because of the potential anti-inflammatory effects, linagliptin, a therapeutic dipeptidyl peptidase-4 inhibitor, is used as an effective drug for diabetic patients whom inflammation prognosis-related factor. We investigated mechanism linagliptin using seven markers. Methods pretreated human umbilical vein endothelial cells (HUVECs), with and lipopolysaccharide (LPS). The cytosolic fractions were evaluated protein kinase A (PKA), B (PKB), C (PKC), ratio reactive oxygen species...
AIM: It is expected that the detection of early gastric cancer (EGC) improved by image enhanced endoscopy including Narrow band imaging (NBI) and Texture color enhancement (TXI).This study aimed to investigate usefulness NBI TXI in improving visibility superficial EGC using difference.METHODS: Among EGCs underwent endoscopic submucosal dissection between August 2020 March 2021, we examined 51 which were observed all three observation methods, NBI, TXI, white light (WLI).For each lesion,...
A woman in her 80s had not defecated for several days and was rushed to our hospital. CT scan showed a fecal mass lodged the colon, diagnosis ileus. The images did indicate any strangulation or necrosis of so we attempted an urgent colonoscopy eliminate mass. completed because abdominal pain became more intense. patient defecate another 4 four days, again performed removed with endoscopic snare. There ulcer, partial obstruction blood flow from sigmoid region rectum. In cases obstructive...
We report a case of male patient in his 70s with Borrmann type 4 gastric cancer, accompanied by obstructive jaundice and duodenal invasion. He was referred to our institution due unexplained liver dysfunction dilation the common bile duct. Upon undergoing upper gastrointestinal endoscopy, stenosis identified. A biopsy from lesion located greater curvature vestibule revealed poorly differentiated adenocarcinoma, specifically signet-ring cell carcinoma (Group 5). Due suspected peritoneal...
Rituximab （RTX） is an anti-CD20 human-mouse chimeric monoclonal antibody that exhibits antibody-dependent, cell-mediated cytotoxicity and complement-dependent cytotoxicity, resulting in antitumor effect with immune cells or complement. RTX approved for the treatment of many diseases including B cell lymphoma rheumatoid arthritis. We examined whether combined gamma interferon （IFNγ） therapy provides a higher than single using B-cell cells. In addition, we investigated mechanisms underlying...
Serum levels of tumor markers, such as carcinoembryonic antigen （CEA） and carbohydrate 19-9 （CA19-9）, are often measured to detect potential malignancy. When these high, the presence or absence malignancy is confirmed via a more detailed examination using gastrointestinal （GI） endoscopy computed tomography. The rate confirmation upon follow-up unknown. This study aimed investigate detection GI for patients with high serum CEA CA19-9. All who underwent between January 2018 February 2019 at...
Abstract A 44‐year‐old man presented to our hospital with lower gastrointestinal bleeding. We performed balloon‐assisted enteroscopy, which revealed diverticulum and stricture at the ileum. The patient underwent segmental small bowel resection diagnosed Meckel's diverticulum. should keep in mind possibility of intestinal due
Aim: Factors that may make endoscopic submucosal dissection (ESD) difficult for operators have been evaluated according to results based on the performance of experienced endoscopists. This study aimed verify predictors gastric ESD beginners. Methods: From January 2015 December 2021, 466 superficial neoplasms were treated with at Showa University Hospital. Excluding 103 lesions performed by experts who more than 80 ESDs, a total 363 included. The divided into two groups experience operator:...
Sessile serrated adenoma/polyps (SSA/Ps) are thought to be precursors of colorectal cancers. However, current endoscopic techniques for differentiating SSA/Ps from conventional hyperplastic polyps (HPs) have low diagnostic accuracy. The aim the present study was assess ability mucosal crypt patterns distinguish HPs. We examined 140 lesions 93 patients that had been diagnosed histologically as or HPs at Showa University Hospital between June 2010 and May 2012. Three experienced colonoscopists...
A 30s-year-old man was admitted to our hospital with abdominal distension. The physical examination revealed jaundice right hypochondralgia, and the laboratory data showed high levels of hepatobiliary enzyme. CT finding cystic dilatation common bile duct (CBD) gallbladder wall thickness. EUS sludges in dilated CBD a stone pancreatic duct. ERCP two defects main (MPD) . He underwent endoscopic sphincterotomy nasopancreatic drainage. Later, he received percutaneous transhepatic drainage (PTGBD)...
Some serrated polyps (SPs) are thought to be precursors of colorectal cancers.However, the endoscopic diagnosis sessile adenoma / (SSA Ps) has been reported have a low accuracy.The aim this study was clarify ability distinguish between SSA Ps and non-SSA by using mucosal crypt patterns combined with ndings.In total, 457 consecutive patients who underwent resection for at Showa University Hospital from April 2007 December 2010 were prospectively enrolled in study.Before treatment, lesions...
We reported that Trastuzumab and gamma interferon combined therapy showed higher synergistic antitumor effect than usual in vitro vivo mouse model before.
ErbB2 is amplified in ～30% of breast cancer patients, and its amplification associated with poor prognosis worse survival outcome. We have studied about the antitumor mechanism Herceptin which a monoclonal antibody to human receptor. When we used anti ErbB2-neu mouse xenograft model, found that number activation interferon gamma positive CD8T cells are changed when effectiveness changed. that. started combined therapy model. Gamma alone showed malignant effects, indicating immune therapies...
Abstract Anti-HER2 antibody is molecular targeted for cancer therapy. Approximately 20% of breast cancers are characterized by overexpression HER2 protein. However, the recurrence rate was 30% and metastasis 18% one year after treatment positive cancer. The resistance to a major problem patients. We previously reported that Gamma Interferon (IFN-γ) combined therapy showed higher anti-tumor effect than usual in vitro vivo mouse experiments. In this study, we evaluated whether anti-HER2 IFN-γ...
The anti-human epidermal growth factor receptor 2 (HER2) antibody (Ab) is a molecularly targeted Ab for cancer therapy. In the field of breast cancer, approximately 20% overexpress HER2 protein. However, recurrence rate 30% and metastasis 18% one year after treatment anti-HER2 positive cancer. resistance to major problem patients. We previously reported that Gamma Interferon (IFN-γ) combined therapy show higher anti-tumor effect than typical in vitro vivo mouse experiments. this study, we...
A 44-year-old man presented to our hospital with lower gastrointestinal bleeding. We performed balloon-assisted enteroscopy, which revealed diverticulum and stricture at the ileum . The patient underwent segmental small bowel resection diagnosed Meckel's diverticulum. should keep in mind possibility of intestinal due
A 20-year-old woman was admitted to our hospital for consolidation therapy acute leukemia. Seventeen days after her treatment, she developed abdominal pain, vomiting, and hematemesis. Laboratory data showed a decrease in neutrophils high inflammatory response. Contrast-enhanced computed tomography (CT) diffuse edematous thickening of the gastric wall small amount ascites. Esophagogastroduodenoscopy hemorrhagic findings with prominent white moss adherence from body fornix. No mucosal changes...
Surgical resection for colorectal cancer（CRC）that deeply invades the submucosa（≥1,000µm）（T1b）has been recommended to reduce potential risk of lymph node metastasis. In clinical settings, cases pathological T1b exist, and these are treated with endoscopic resection（ER）for various reasons. However, factors that influence choice ER treat CRC remain unknown. Therefore, in this study, we investigated associated treatments patients diagnosed or a more invading CRC. To achieve aim, conducted case...