A5085782360- Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Viral-associated cancers and disorders
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Antibiotic Resistance in Bacteria
- Acute Myeloid Leukemia Research
- Breast Lesions and Carcinomas
- Metastasis and carcinoma case studies
- Breast Cancer Treatment Studies
- Gastrointestinal Tumor Research and Treatment
- Mast cells and histamine
- Eosinophilic Disorders and Syndromes
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Toxin Mechanisms and Immunotoxins
- T-cell and Retrovirus Studies
- Hematopoietic Stem Cell Transplantation
- HER2/EGFR in Cancer Research
- Cytomegalovirus and herpesvirus research
- Cancer Immunotherapy and Biomarkers
- Multiple Myeloma Research and Treatments
Showa University
2013-2025
Showa University Koto Toyosu Hospital
2018
Koto Hospital
2018
Showa University Hospital
2017
Tokyo Metropolitan Institute of Medical Science
2011
Toshima Hospital
2000-2002
Metropolitan Hospital
2000
Metropolitan Hospital Center
2000
University of Vienna
1992-1993
Background. Proliferating cell nuclear antigen (PCNA), a proliferation marker, epidermal growth factor receptor (EGFR), glycoprotein that plays role in tumorigenesis by binding the mitogenic factor, and P-glycoprotein, mdr gene product, are considered to be of prognostic relevance different tumor types. Parameters allow prediction course disease colorectal cancer would aid development improved treatment strategies. Methods. Immunohistochemical staining was performed on paraffin-embedded...
Although dysfunction of VE-cadherin-mediated adherence junctions in vascular endothelial cells (ECs) is thought to be one the initial steps atherosclerosis, little known regarding how VE-cadherin disrupted during atherogenic development. This study focused on role calpain, an intracellular cysteine protease, proteolytic disorganization and subsequent progression atherosclerosis.Increased expression m-calpain was observed aortic ECs atherosclerotic lesions humans low-density lipoprotein...
S ummary . The cell surface molecule encoded by the proto‐oncogene c‐kit has recently been identified as receptor for a growth factor variously termed stem (SCF), mast or steel factor. Using antibody 17F11 we analysed, in triple staining experiments, profile and scatter characteristics of + CD34 human haemopoietic progenitor cells. In 10 normal bone marrow samples found 19–51% cells to coexpress c‐kit. These turned out represent phenotypically heterogeneous population. A considerable...
Eosinophilic gastroenteritis (EGE) is characterized by eosinophilic infiltration of the digestive organs, most commonly stomach and duodenum. Symptoms EGE are nonspecific include nausea, vomiting, abdominal pain, dyspepsia, malabsorption, ascites weight loss. The various symptoms depend on its location depth gastrointestinal eosinophil infiltration. We report a case presenting with acute pancreatitis caused milk allergy. patient's rapidly improved after treatment corticosteroids, he remained...
Abstract Aim Laser microdissection (LMD) and liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) enable clinicians to analyse proteins from tissue sections. In nephrology, these methods are used diagnose diseases of abnormal protein deposition, such as amyloidosis, but they seldom applied the diagnosis pathophysiological understanding human glomerular diseases. Methods Renal biopsy specimens were obtained five patients with IgA nephropathy (IgAN), membranous (MN) kidney transplant...
Antibody–drug conjugates (ADCs), which are currently being developed, may become promising cancer therapeutics. Folate receptor α (FOLR1), a glycosylphosphatidylinositol-anchored membrane protein, is an attractive target of ADCs, as it largely absent from normal tissues but overexpressed in malignant tumors epithelial origin, including ovarian, lung, and breast cancer. In this study, we tested the effects novel anti-FOLR1 antibody–eribulin conjugate MORAb-202 non-small cell lung (NSCLC)...
Background: Pancreatic and hepatic mucinous cyst neoplasms (MCNs) have a malignant potential, but indolent MCNs are not uncommon. Materials Methods: The pathological genetic characteristics of resected (n=15) categorized by the amount mucin lining epithelium were investigated. Results: divided into two groups: (i) rich (r)-MCN group (n=6), in which more than half was lined abundant epithelium; (ii) poor (p)-MCN (n=9), consisted remaining cases. Three patients r-MCN showed invasive carcinoma...
Pancreatic cancer has an extremely poor prognosis, and identification of novel predictors therapeutic efficacy prognosis is urgently needed. Chemoresistance-related molecules are correlated with may be effective targets for treatment. Here, we aimed to identify chemoresistance in pancreatic cancer. We established 10 patient-derived xenograft (PDX) lines from patients performed next-generation sequencing (NGS) tumor tissues PDXs after treatment standard drugs. a gene-transferred cell line...
Glycocalyx (GCX) is a thin layer of negatively charged glycoproteins that covers the vascular endothelial surface and regulates various biological processes. Because delicate fragile properties this structure, it difficult to detect GCX morphologically. We established simple method for three-dimensional visualization using low-vacuum scanning electron microscopy (LVSEM) on formalin-fixed paraffin-embedded (FFPE) sections. Mouse kidney tissue was fixed with 10% buffered formalin containing 1%...
Abstract Background Dedicated breast positron emission tomography (dbPET) has been developed for detecting smaller cancer. We investigated the diagnostic performance of dbPET in patients with known Methods Eighty-two preoperative cancer were included study (84 tumours: 11 ductal carcinomas situ [DCIS], 73 invasive cancers). They underwent mammography (MMG), ultrasonography (US), and contrast-enhanced magnetic resonance imaging (MRI) before whole-body PET/MRI (WBPET/MRI) dbPET. evaluated...
Rituximab is widely used for the treatment of B‐cell non‐Hodgkin's lymphoma (NHL), and encouraging results have been obtained. However, some CD20‐positive NHL show minimal response to rituximab, indicating that effect depends on presence or absence an unidentified factor. We analyzed relationship between rituximab plus chemotherapy expression Ki‐67, p53 bcl‐2 several clinical variables in cases B‐NHL, particularly follicular (FL) diffuse large (DLBCL). Forty‐four patients were included...
Senile EBV‐associated B‐cell lymphoproliferative disorder (LPD) was proposed as a new disease entity in 2003. This condition has high incidence elderly people without underlying immunodeficiencies, and is characterized by EBV‐positive proliferation with polymorphic composition. Histologically, the two subtypes. The LPD (PLPD) subtype preferable prognosis, whereas large cell lymphoma (LCL) involves aggressive progression. Reported herein case of senile EBV‐BLPD indolent clinical features PLPD...
Abstract Background and Aim: The World Health Organization (WHO) has adopted criteria for the histological differential diagnosis of gastric extranodal marginal zone B‐cell lymphoma mucosa‐associated lymphoid tissue (GML) based on proposed by Wotherspoon in 1993 (WHO/Wotherspoon score). These are commonly used pathologists initial diagnoses, but have not been uniformly post‐treatment evaluation GML. In 2003, Groupe d’Etude des Lymphomes de l’Adult (GELA) a new grading system (GELA grade)...
Pagetoid reticulosis is a rare cutaneous T‐cell lymphoma with striking epidermotropism similar to that present in Paget's disease. There are two forms of pagetoid reticulosis: localized and disseminated. Reported herein an autopsy case disseminated CD4 – /CD8 phenotype T cells massive invasion the lungs pancreas. The abnormal epidermis expressed protein derived from rearranged receptor β gene, this feature was used confirm monoclonality these by polymerase chain reaction. At present, World...
The patient was a 54-year-old male who had been suffering from extensive ulcerative colitis (UC) for 17 years. Colonoscopy revealed an elevated lesion in the affected rectum, and its biopsy demonstrated neuroendocrine carcinoma (NEC). surgical specimen obtained on laparoscopic high anterior resection showed active inflammatory dysplastic lesions three grossly visible multifocal malignant lesions: polypoid fungating tumor of NEC (type 1, 20 mm diameter, pT3) that preoperatively noticed,...
Recent studies have highlighted the pathogenic roles of IL-17-producing CD8+ T cells (T-cytotoxic 17 [Tc17]) in psoriasis. However, underlying mechanisms Tc17 induction remain unclear. In this study, we focused on subsets Th17 and their mechanism promotion responses. We determined that Th17-enriched fraction expressed melanoma cell adhesion molecule (MCAM) CCR6, but not CD161, because subset produced IL-17A abundantly presence these peripheral blood patients has been correlated with severity...
The patient was a 60-year-old man without any particular complaints, but he underwent abdominal computed tomography (CT) and magnetic resonance cholangiopancreatography (MRCP) due to fatty liver, which revealed two similar cystic lesions regarded as branch duct-type intraductal papillary mucinous neoplasm (BD-IPMN) in the pancreatic body [BD-IPMN (b), 16 mm size] tail (t), 13 “high-risk stigmata” or “worrisome features”. He subsequently received follow-up by MRCP every 6 months. Two years...