A5039314616- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Respiratory viral infections research
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Birth, Development, and Health
- Gut microbiota and health
- Congenital Anomalies and Fetal Surgery
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Immunodeficiency and Autoimmune Disorders
- Neuroscience of respiration and sleep
- Telomeres, Telomerase, and Senescence
- Preterm Birth and Chorioamnionitis
- Pediatric health and respiratory diseases
- Neonatal and fetal brain pathology
- Diabetes and associated disorders
- Thermal Regulation in Medicine
- Child and Adolescent Health
- Clinical Nutrition and Gastroenterology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Breastfeeding Practices and Influences
- Parvovirus B19 Infection Studies
- Obesity, Physical Activity, Diet
- Pancreatic function and diabetes
Karolinska Institutet
2013-2025
Karolinska University Hospital
2011-2025
Ottawa Hospital
2021-2025
Ottawa Hospital Research Institute
2021-2025
Science for Life Laboratory
2020-2022
Ottawa University
2021
Health Canada
2021
Sachs' Children and Youth Hospital
2004
Epidemiological data suggest that early life exposures are key determinants of immune-mediated disease later in life. Young children also particularly susceptible to infections, warranting more analyses immune system development Such mostly have been performed mouse models or human cord blood samples, but these cannot account for the complex environmental influencing newborns after birth. Here, we longitudinal 100 newborn children, sampled up 4 times during their first 3 months From μL...
Immune-microbe interactions early in life influence the risk of allergies, asthma, and other inflammatory diseases. Breastfeeding guides healthier immune-microbe relationships by providing nutrients to specialized microbes that turn benefit host's immune system. Such bacteria have co-evolved with humans but are now increasingly rare modern societies. Here we show a lack bifidobacteria, particular depletion genes required for human milk oligosaccharide (HMO) utilization from metagenome, is...
Increasing numbers of survivors preterm birth are growing into adulthood today. Long-term health-effects prematurity still poorly understood, but include increased risk for diabetes, obesity and cardiovascular diseases in adult life. To test if reduced physical fitness may be a link the causal chain later life, association exercise capacity was investigated. The hypothesis that contributes independently other factors to lower adulthood.Population-based national cohort study all males...
Abstract Preterm newborns are more likely to suffer from infectious diseases at birth compared children delivered term. Whether this is due compromised cellular, humoral, or organ-specific development remains unclear. To begin define whether maternal–fetal antibody transfer profiles differ across preterm (PT) and fullterm (FT) infants, the overall quantity functional quality of an array 24 vaccine-, endemic pathogen-, common antigen-specific antibodies were assessed a cohort 11 PT 12...
Pediatric organ transplant recipients have a higher risk for wait list mortality due to the scarcity of size matched organs. Neonatal donation could potentially ameliorate discrepancy but is currently not implemented in Sweden. This study aims evaluate potential neonatal central Sweden using standardized protocol with specific criteria. Data on 2,061 neonates who deceased from 2006 2016 were collected; 308 met criteria possible donation. Medical records all donors reviewed, identifying 85...
There are few independent, population-based reports that estimate the risk of hospitalization respiratory syncytial virus (RSV)-infected infants before and during palivizumab era. We present figures from greater Stockholm area three seasons after introduction relate them to data based on 1400 hospitalizations for RSV disease in same population 1987 through 1998.The number births, neonatal complications prescriptions was obtained. retrieved information about all infant confirmed infections...
SUMMARY Immune-microbe interactions early in life influence an individual’s risk of developing allergies, asthma and some autoimmune disorders. Breastfeeding helps guide the development healthy immune-microbe relationships, part by providing nutrients to specialized microbes that turn benefit host its immune system. Such bacteria having co-evolved with humans are associated reduced risks mediated diseases but increasingly rare modern societies. Here we map immunological sequence events,...
Pyridoxine-dependent epilepsy is a rare autosomal recessive disease usually associated with neonatal seizures that do not respond to common antiseizure medications but are controlled by pyridoxine administration. Because the symptoms can mimic disorders, diagnosis be initially missed or delayed. We report fatal case of boy who was diagnosed respiratory distress, birth asphyxia, and persistent pulmonary hypertension whose condition rapidly deteriorated during first day life.
Abstract Aim Inflammation is a major factor in the pathophysiology of bronchopulmonary dysplasia ( BPD ), and it contributes to accelerated telomere shortening cellular ageing. This study aimed determine its effect on length lung function school‐aged children born preterm with . Methods We examined 29 , Stockholm county 1998–99, along 28 allergic asthma at term matched for age gender. At 10 years age, we measured relative RTL ) blood by quantitative polymerase chain reaction, spirometry...
Hepatocyte transplantation is a promising treatment for liver failure and inborn metabolic diseases, but progress has been hampered by scarcity of available organs. Here, hepatocytes isolated from livers procured neonatal hepatocyte donation program within research setting were assessed function suitability transplantation. Organ was considered infants who died in intensive care the Stockholm region during 2015–2021. Inclusion when decision to discontinue life-sustaining had made hepatectomy...
Extremely preterm infants are born with immature lungs and exposed to an inflammatory environment as a result of oxidative stress. This may lead airway remodeling, cellular aging the development bronchopulmonary dysplasia (BPD). Reliable markers that predict long-term consequences BPD in infancy still lacking. We analyzed two biomarkers lung function, telomere length YKL-40, respectively, at 10 years age children history (n = 29). For comparison, these were also evaluated sex-and-age-matched...
Abstract Aim Neonatal diabetes is rare, and treatment challenging. We present aspects on treatment, genetics incidence. Method This was a prospective cohort study including all cases in our area Sweden. compared with data from the National Diabetes Registry, Quality Register Patient Register. Results In 19‐year period January 1, 1998 to December 31, 2016, we treated seven infants, five of them boys. Six patients used subcutaneous insulin pump, smallest patient started at weight 938 g. Most...
Gregory and associates introduced CPAP for newborns in 1971. (1) At this time, ventilators were not designed newborns, mechanical ventilation was used only as an ultimate therapy, often with very poor outcome. The head chamber, or so-called box, rapidly gained interest around the world, its effectiveness striking, mortality respiratory distress syndrome (RDS) decreasing from 35% to 55% 15% 20%. In late 1970s 1980s, infant developed rapidly. focus care of newborn shifted toward ventilation,...
Background . After perinatal asphyxia, the cerebellum presents more damage than previously suggested. Objectives To explore if antioxidant N-acetylcysteine amide (NACA) could reduce cerebellar injury after hypoxia-reoxygenation in a neonatal pig model. Methods Twenty-four newborn pigs two intervention groups were exposed to 8% oxygen and hypercapnia, until base excess fell −20 mmol/l or mean arterial blood pressure declined <20 mmHg. hypoxia, they received either NACA (NACA group,...
Abstract Background Antisecretory Factor (AF) is a protein present in breastmilk that regulates inflammatory processes. We aimed to investigate the level of AF mothers’ own milk (MOM) relation sepsis and other neonatal morbidities preterm infants. Methods Samples infant plasma were collected at 1, 4, 12 weeks after birth from 38 mothers their 49 infants born before 30 gestation. AF-compleasome MOM was determined by sandwich enzyme-linked immunosorbent assay (ELISA) markers panel 92 proteins....
Preterm infants are more susceptible to inflammatory complications than term infants. Human milk contains numerous bioactive components protecting the newborn infant. Antisecretory factor, a protein regulating secretory and processes by complex binding with complement factors, is present in human milk.To describe antisecretory factor (1) mother's own preterm infants; (2) donor before after Holder pasteurization.The study was prospective, longitudinal, explorative, descriptive....
Abstract Preterm newborns are more likely to suffer from infectious diseases at birth compared children delivered term. Whether this is due compromised cellular, humoral, or organ-specific development remains unclear. Recent studies have shown that while preterm an aberrant cellular immune response, these infants receive similar maternal anti-viral IgG repertoires term children, albeit lower concentrations. These data point selectivity in placental transfer distinct gestational ages, ensure...