A5080856249- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Glycosylation and Glycoproteins Research
- Children's Physical and Motor Development
- Neural dynamics and brain function
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Ubiquitin and proteasome pathways
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Photoreceptor and optogenetics research
- Spaceflight effects on biology
- Cellular transport and secretion
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Parkinson's Disease and Spinal Disorders
- Galectins and Cancer Biology
- Olfactory and Sensory Function Studies
- Pain Mechanisms and Treatments
- Sleep and Wakefulness Research
- Muscle activation and electromyography studies
- 14-3-3 protein interactions
- Vestibular and auditory disorders
- Cannabis and Cannabinoid Research
Université de Lille
2011-2025
Unité de Recherche Pluridisciplinaire Sport, Santé, Société
2015-2025
Université d'Artois
2022-2025
Université Lille Nord de France
2011-2015
Laboratoire Roberval
2015
Johannes Gutenberg University Mainz
2005-2009
Aarhus University
2000-2009
Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes
1997
Sorbonne Université
1997
Collège de France
1995
Our aim was to analyze the role of phosphatidylinositol 3-kinase (PI3K)-AKT and MAPK signaling pathways in regulation muscle mass slow-to-fast phenotype transition during hindlimb unloading (HU). For that purpose, we studied, rat slow soleus fast extensor digitorum longus muscles, time course anabolic PI3K-AKT-mammalian target rapamycin, catabolic PI3K-AKT-forkhead box O (FOXO), pathway activation after 7, 14, 28 days HU. Moreover, performed chronic low-frequency electrostimulation HU...
A sedentary lifestyle can lead to motor and cognitive deficits, increasing the risk of neurodegenerative diseases in ageing. Emerging hypotheses suggest that these functional alterations may be related energy metabolism. Indeed, ATP produced by mitochondria is essential for muscle contraction, neurotransmission brain plasticity processes. Although a has been associated with mitochondrial skeletal muscle, potential effects on structures have yet investigated. The present study aimed determine...
Alterations in dopamine neurotransmission animal models of epilepsies have been frequently demonstrated using invasive neuroscience or ex vivo techniques. We aimed to test whether corresponding alterations could be detected by noninvasive brain imaging with positron emission tomography (PET) the chronic phase rat pilocarpine model temporal lobe epilepsy.Six pilocarpine-treated Wistar rats exhibiting spontaneous recurrent seizures and nine control were studied PET [(18)F]-fallypride, a...
Childhood is a period of construction the organism, during which interactions with environment and regular physical activity are necessary for maturation neuronal networks. An atypical sensorimotor childhood (due to bed-rest or neurodevelopmental disorders) impacts development neuromuscular system. A model restriction (SMR) developed in rats has shown that casting pups' hind limbs from postnatal day 1 (P1) P28 induced severe perturbation motor behavior, due muscle weakness as well...
Abstract Children with neurodevelopmental disorders, such as developmental coordination disorder (DCD), exhibit gross to fine sensorimotor impairments, reduced physical activity and interactions the environment people. This co‐exists cognitive deficits, executive dysfunctions learning impairments. Previously, we demonstrated in rats that limited amounts atypical patterns of movements somatosensory feedback during early movement restriction manifested adulthood degraded postural locomotor...
Although modifications of the survival motor neurone gene are responsible for most spinal muscular atrophy (SMA) cases, molecular pathophysiology and target proteins involved still unknown. The aim this study was to compare expression contractile regulatory protein isoforms in quadriceps muscles from SMA children with age-matched control quadriceps.The isoform patterns myosin heavy chains (MHC), troponin subunits (T, C I) tropomyosin were determined by immunoblotting, reverse...
A chronic reduction in neuromuscular activity through prolonged body immobilization human alters motor task performance a combination of peripheral and central factors. Studies performed rat model sensorimotor restriction have shown functional biochemical changes cortex. However, the underlying mechanisms are still unclear. Interest was turned towards possible implication Insulin-like Growth Factor 1 (IGF-1), growth factor known to mediate neuronal excitability synaptic plasticity by...
Interaction with the environment appears necessary for maturation of sensorimotor and cognitive functions in early life. In rats, a model restriction (SMR) from postnatal day 1 (P1) to P28 has shown that low atypical activities induced perturbation motor behavior due muscle weakness functional disorganization primary somatosensory cortices. present study, our objective was understand how SMR affects muscle–brain dialogue. We focused on irisin, myokine secreted by skeletal muscles response...
Immortalized neural precursor cell lines carrying the polyoma large tumor (T) gene have been shown previously to retain a clear-cut contact inhibition of growth and differentiate in vitro. In present study, we identified isolated cDNA clones corresponding RNA expressed preferentially when these cells reach confluence. One them, NPDC-1, is specifically nervous system. The transfection dividing with NPDC-1 expression vector results proliferation. addition, stable introduction into transformed...
Sensorimotor restriction by a 14-day period of hindlimb unloading (HU) in the adult rat induces reorganization topographic maps and receptive fields. However, underlying mechanisms are still unclear. Interest was turned towards possible implication intracellular MAPK signaling pathway since Extracellular-signal-Regulated Kinase 1/2 (ERK1/2) is known to play significant role control synaptic plasticity. In order better understand cortical plasticity rats submitted sensorimotor restriction, we...