A5064907266- Reproductive Biology and Fertility
- Childhood Cancer Survivors' Quality of Life
- Renal and related cancers
- Reproductive Health and Technologies
- Ethics and Legal Issues in Pediatric Healthcare
- Assisted Reproductive Technology and Twin Pregnancy
- Abdominal Surgery and Complications
- Cystic Fibrosis Research Advances
- Ovarian function and disorders
- BRCA gene mutations in cancer
- Electrolyte and hormonal disorders
- Fungal Infections and Studies
- Birth, Development, and Health
- Child and Adolescent Health
- Antifungal resistance and susceptibility
- Ovarian cancer diagnosis and treatment
- Anesthesia and Neurotoxicity Research
Princess Máxima Center
2020-2024
NGC Aerospace (Canada)
2022
Kidney size is sex-dimorphic and regulated by androgens in adult humans mice. However, the effects of developmental androgen deficiency on kidneys remain elusive. We hypothesized that program future kidney growth during a fetal development. Male mice lacking main testosterone-producing enzyme HSD17B3 had reduced testosterone at embryonic day 15.5, but concentrations increased E18.5, creating short time window resulting males. In male Hsd17b3-/- kidneys, nephron development was qualitatively...
Background Childhood cancer patients often remain uninformed regarding their potential risk of gonadal damage. In our hospital we introduced a five step standard oncofertility care plan for all newly diagnosed female aiming to identify, inform and triage 100% counsel at high (HR) This observational retrospective study (PEARL study) evaluated the use this in first full year national cohort. Methods The steps consist 1)timely (preferably before start gonadotoxic treatment) identification new...
The survival of childhood Wilms tumor is currently around 90%, with many survivors reaching reproductive age. Chemotherapy and radiotherapy are established risk factors for gonadal damage used in both COG SIOP treatment protocols. infertility patients low but increases intensification including the use alkylating agents, whole abdominal radiation or to pelvis. Both protocols aim limit gonadotoxic treatment, unfortunately this cannot be avoided all patients. Infertility considered one most...
The 5-year survival rate of childhood cancer exceeds 80%, however, many survivors develop late effects including infertility. aim this study was to evaluate the current status oncofertility care at Vilnius University Hospital Santaros Klinikos (VULSK) within framework EU-Horizon 2020 TREL project.All parents or patients aged 12-17.9 years treated from July 1, 2021 until 2022 were invited complete an oncofertility-care-evaluation questionnaire. After completing questionnaire, triaged low-risk...
Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in children with cancer. Studies on the clinical characteristics IFI solid tumors limited. This Dutch retrospective cohort study reviewed medical records 61 to analyze during their full treatment period. Seven episodes were reported 6/61 patients (10%), all diagnosed intermediate-risk or high-risk Wilms tumor neuroblastoma. Larger studies necessary reveal determinants this group value prophylaxis.
Currently the five-year survival of childhood cancer is up to 80% due improved treatment modalities. However, majority survivors develop late effects including infertility. Survivors describe infertility as an important and life-altering effect. Fertility preservation options are becoming available pre- postpubertal patients diagnosed with fertility care now aspect in treatment. The use depends on quality counseling this delicate issue. aim manuscript present a questionnaire determine impact...
<h3>Objective</h3> To discover new variants associated with low ovarian reserve after gonadotoxic treatment among adult female childhood cancer survivors using a genome-wide association study approach. <h3>Design</h3> Genome-wide study. <h3>Setting</h3> Not applicable. <h3>Patients</h3> A discovery cohort of from the pan-European PanCareLIFE (n = 743; median age: 25.8 years), excluding those who received bilateral irradiation, oophorectomy, central nervous system or total body stem cell...