A5067012889- Palliative Care and End-of-Life Issues
- Suicide and Self-Harm Studies
- Patient-Provider Communication in Healthcare
- Regulation of Appetite and Obesity
- Grief, Bereavement, and Mental Health
- Neuropeptides and Animal Physiology
- Childhood Cancer Survivors' Quality of Life
- Hemodynamic Monitoring and Therapy
- Biochemical Analysis and Sensing Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Patient Dignity and Privacy
- Respiratory Support and Mechanisms
- Mental Health Treatment and Access
- Qualitative Research Methods and Ethics
- Adipose Tissue and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Heart Rate Variability and Autonomic Control
- Cancer survivorship and care
- Neurotransmitter Receptor Influence on Behavior
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Operations and Scheduling Optimization
- Scheduling and Timetabling Solutions
- Social Media in Health Education
- Anatomy and Medical Technology
- Surgical site infection prevention
The University of Texas Medical Branch at Galveston
2016-2024
Cardiff University
2013-2021
Public Health Wales
2020
Marie Curie
2014-2020
Queens College, CUNY
2012-2014
Peterborough and Stamford Hospitals NHS Foundation Trust
2013
University of Rochester
1994
Monroe Community Hospital
1994
To present and discuss the views of researchers at an academic palliative care research centre on encounters with terminally ill patients in home setting to generate a list recommendations for qualitative working end-of-life care.Eight took part consensus meeting their experiences undertaking interviews. The were varying backgrounds all reported having experience interviewing patients, but one had environment.The main areas discussed by included: whether participation unintentionally becomes...
Abstract Background Excess tumor necrosis factor (TNF) is implicated in the pathogenesis of hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels fibrin(ogen) brain, behavioral changes, and mortality. However, role TNF eCM within brain parenchyma, particularly directly on neurons, remains underdefined. Here, we investigate electrophysiological consequences neuronal excitability cell signaling mechanisms that contribute to observed phenotypes. Methods The...
Abstract Obesity is a large and growing global health problem with few effective therapies. The present study investigated metabolic physiological benefits of nicotinamide N-methyltransferase inhibitor (NNMTi) treatment combined lean diet substitution in diet-induced obese mice. NNMTi accelerated improved body weight fat loss, increased whole-body mass to ratio, reduced liver epididymal white adipose tissue weights, decreased adiposity, hepatic steatosis, relative alone. Importantly,...
This study was designed to examine the relationship between cognitive function and endogenous levels of NGF, low-affinity NGF receptor (LNGFR), amyloid precursor protein (APP) mRNAs. Using 3 month (n = 5), 18 40), 29 17) Fischer-344 male rats, assessed with Morris water maze, reverse transcription polymerase chain reaction were used quantify APP mRNAs, LNGFR determined an ELISA. Cognitive declined progressively age from months months, but only RNA content in tissue significantly months....
Obesity is a growing public health concern, with 37.5% of the adult population in need therapeutics that are more efficacious better side effect profile. An innovative target this regard neuromedin U, neuropeptide shown to suppress food intake and attenuate weight gain animal models. These effects U on feeding behavior thought be related agonism at centrally expressed receptor 2 (NMUR2). As peptides present unique challenges limit their therapeutic potential, discovery small-molecule NMUR2...
Physiological closed-loop controlled (PCLC) medical devices, such as those designed for blood pressure regulation, require substantial evidence of safety and efficacy in real-world clinical settings. However, relying solely on limited animal studies may not capture the diverse range physiological conditions. Credible mathematical models can complement these by allowing testing device against simulated patient scenarios. This research involves development validation a low-order...
Objective To study how treatment decisions are made alongside the lung cancer clinical pathway. Methods A prospective, multicentre, multimethods, five-stage, qualitative study. Mediated discourse, thematic, framework and narrative analysis were used to analyse transcripts. Results 51 health professionals, 15 patients with advanced cancer, family members 18 expert stakeholders recruited from three UK NHS trusts. Multidisciplinary team (MDT) constructed recommendations around patient...
Global loss of the neuropeptide Neuromedin-U (NMU) is associated with increased bone formation and high mass in male female mice by twelve weeks age, suggesting that NMU suppresses osteoblast differentiation and/or activity vivo. highly expressed numerous anatomical locations including skeleton hypothalamus. This raises possibility exerts indirect effects on remodeling from an extra-skeletal location such as brain. Thus, present study we used microinjection to deliver viruses carrying...
Abstract Self‐harm in young people remains a significant concern. Studies of emergency departments have centred on negative professional attitudes. There has been limited interrogation and theorisation what drives such attitudes, the contexts that sustain them. Adopting complex systems lens, this study aimed to explore how shape patient interactions. It draws upon interviews with healthcare affiliated professionals ( n = 14) UK case hospital, primary focus department. Data were analysed...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> To develop a high-fidelity mathematical model intended to replicate the cardiovascular (CV) responses of critically ill patient vasoplegic shock-induced hypotension and vasopressor therapy. xmlns:xlink="http://www.w3.org/1999/xlink">Methods:</i> The consists lumped-parameter CV physiology with baroreflex modulation feedback phenomenological dynamic dose-response vasopressor....
In healthcare, many service evaluation questionnaires use free-text boxes without formal mechanisms for analysis. Patients and carers spend time documenting concerns that are often ignored or managed locally in an ad hoc manner. Currently, palliative care experiences of patients Wales measured using a questionnaire, comprising both closed open-ended questions. Previous research, exploring responses from this suggests questionnaire refinement should accommodate users' expressed priorities...
Introduction Patient-centred care is essential to the delivery of healthcare; however, this necessitates direct patient involvement in clinical decision-making and can be challenging for patients diagnosed with advanced non-small cell lung cancer where there may misunderstanding extent disease, prognosis aims treatment. In context, decisions are complex a need balance risks benefits, including treatment palliative intent. The aim PACT study identify information decision support needs...
Abstract This paper presents a virtual patient generator (VPG) intended to be used for pre-clinical in silico evaluation of autonomous vasopressor administration algorithms the setting experimentally induced vasoplegia. Our VPG consists two main components: (i) mathematical model that replicates physiological responses experimental vasoplegia (induced by sodium nitroprusside (SNP)) and resuscitation via phenylephrine (PHP) (ii) parameter vector sample form multi-dimensional probability...
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrotic interstitial lung disease of unknown origin and median survival three years. National Institute for Clinical Excellence guidelines promote patient carer centred approaches, emphasising multidisciplinary, supportive palliative care interventions. However there limited evidence experiences to guide pathways. Aim(s) method(s) Multi-centre mixed methods study identifying needs patients carers inform future clinical...
Background The iWantGreatCare (iWGC) questionnaire was developed by the Palliative Care Implementation Board and aims to evaluate palliative care service provision in Wales, through appraisal of care, as encapsulated 10 questions a free text box. In order fully reflect patients' families' experiences we previously undertook qualitative analysis comments 596 patients carers, which highlighted areas not assessed scored results. Following this analysis, are undertaking further project refine...
Introduction Online communities are full of discussions about illness, death and dying these communications increasingly repositioned within research environments as sources publically available data. As a palliative care centre, we have been keen to embrace social media our work, however, with no definitive set ethical or practical guidelines unsure how best proceed. The centre thus initiated two consensus days construct workable, framework for future in the field. Aim(s) method(s)...