A5037467951- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
- NF-κB Signaling Pathways
- Cannabis and Cannabinoid Research
- Essential Oils and Antimicrobial Activity
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- SARS-CoV-2 and COVID-19 Research
- Diet, Metabolism, and Disease
- Plant biochemistry and biosynthesis
- Traditional Chinese Medicine Analysis
- Osteoarthritis Treatment and Mechanisms
- Plant-based Medicinal Research
- Coenzyme Q10 studies and effects
- Epigenetics and DNA Methylation
- Image Processing and 3D Reconstruction
- Peripheral Neuropathies and Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Periodontal Regeneration and Treatments
- Sesquiterpenes and Asteraceae Studies
- Microbial Natural Products and Biosynthesis
Charité - Universitätsmedizin Berlin
2020-2022
Wroclaw Medical University
2017-2022
Humboldt-Universität zu Berlin
2022
Freie Universität Berlin
2022
Orthopädische Universitätsklinik
2003
Heidelberg University
2003
University Hospital Heidelberg
2003
More than a year has passed since the world began to fight novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for Coronavirus disease 2019 (COVID-19) pandemic, and still it spreads around world, mutating at same time. One of sources compounds with potential antiviral activity is Traditional Chinese Medicinal (TCM) plants used in China supportive treatment COVID-19. Reynoutria japonica important part Shu Feng Jie Du Granule/Capsule-TCM herbal formula, recommended...
The rapidly developing pandemic, known as coronavirus disease 2019 (COVID-19) and caused by the severe acute respiratory syndrome 2 (SARS-CoV-2), has recently spread across 213 countries territories. This pandemic is a dire public health threat—particularly for those suffering from hypertension, cardiovascular diseases, pulmonary or diabetes; without approved treatments, it likely to persist recur. To facilitate rapid discovery of inhibitors with clinical potential, we have applied ligand-...
The CB1 cannabinoid receptor (CB1R) contains one of the longest N termini among class A G protein-coupled receptors. Mutagenesis studies suggest that allosteric binding site cannabidiol (CBD) involves residues from terminal domain. In order to study CBD CB1R we modeled whole N-terminus this using replica exchange molecular dynamics with solute tempering (REST2) approach. Then, obtained structures terminus were used for ligand docking. natural agonist, Δ9-THC, was docked orthosteric and a...
Abstract Betulin is a heavily studied natural compound for its use as an anticancer or pro-regenerative agent. The structural similarity between betulin to steroids gives rise the idea that substance may well act anti-inflammatory drug. This study first describe properties of betulinic acid, betulin, and derivatives with amino acids 1,4-diaminebutane (Dab), 1,3-diaminepropane (Dap), Ornithine (Orn), lysine (Lys) on murine macrophages from lymphoma site. compounds were compared dexamethasone....
Background: The COVID-19 pandemic is being battled via the largest vaccination campaign in history, with more than eight billion doses administered thus far. Therefore, discussions about potentially adverse reactions, and broader safety concerns, are critical. U.S. Vaccination Adverse Event Reporting System (VAERS) has recorded side effects for over 30 years. About 580,000 events have been filed far, primarily Johnson & (New Jersey, USA), Pfizer/BioNTech (Mainz, Germany), Moderna (Cambridge,...
Inhibition of cholinesterases remains one a few available treatment strategies for neurodegenerative dementias such as Alzheimer’s disease and related conditions. The current study was inspired by previous data on anticholinesterase properties diterpenoids from Perovskia atriplicifolia other Lamiaceae species. acetylcholinesterase (AChE) butyrylcholinesterase (BChE) inhibition the three new natural compounds—(1R,15R)-1-acetoxycryptotanshinone (1), (1R)-1-acetoxytanshinone IIA (2),...
Vanicosides A and B are the esters of hydroxycinnamic acids with sucrose, occurring in a few plant species from Polygonaceae family. So far, vanicosides have not been evaluated for anticancer activity against human malignant melanoma. In this study, we tested these two natural products, isolated Reynoutria sachalinensis rhizomes, melanoma cell lines (amelanotic C32 line melanotic A375 line, both bearing endogenous BRAFV600E mutation) normal lines—keratinocytes (HaCaT) primary fibroblast...
Botanicals used in Traditional Chinese Medicine (TCM) are a rich source for drug discovery and provide models multi-component development. To facilitate the studies of actions TCM drugs expand their applications, comprehensive database is urgently required. One online resource connects all relevant data from multiple scientific sources languages. Drug information published databases official Pharmacopoeia as well specialized meta-websites such Kew's Medicinal Plant Names Service was...
Leaves of Eriobotryajaponica (loquat) have been used in Traditional Chinese Medicine with beneficial effects numerous diseases. Extracts from loquat leaves are rich antioxidants, containing among others: triterpenes, sesquiterpenes, flavonoids, tannins, and megastigmane glycosides. However, there is no conclusive study revealing which these compounds the main bioactive principles. The goal this was to pinpoint responsible for strong antioxidant activity. Eriobotryaefolium extracted...
Fragestellung: Tissue Engineering von Bandscheibengewebe (BS) könnte ein attraktiver Ansatz zur kausalen Therapie Bandscheibenerkrankungen sein. Adulte mesenchymale Stammzellen (MSC) stellen eine autologe Zellquelle mit vielversprechenden Differenzierungseigenschaften dar. Ziel dieser Studie war es, den molekularen Phänotyp kultivierter BS-Zellen dem Chondrozyten aus Knorpel zu vergleichen und prüfen, ob MSC in vitro BS-ähnlichen Zellen ausdifferenzieren können.
Abstract Betulin is a heavily studied natural compound for its use as an anticancer or pro-regenerative agent. The structural similarity of betulin to steroids gives rise the idea, that substance may well act anti-inflammatory drug. This study first describe properties betulinic acid, betulin, and derivatives with amino acids - 1,4-diaminebutane (Dab), 1,3-diaminepropane (Dap), Ornithine (Orn), Lysine (Lys) on murine macrophages from lymphoma site. compounds were compared dexamethasone. To...