Paulo César de Lima Nogueira

ORCID: 0000-0003-0832-1047
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About
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Research Areas
  • Essential Oils and Antimicrobial Activity
  • Phytochemistry and Biological Activities
  • Insect Pest Control Strategies
  • Traditional and Medicinal Uses of Annonaceae
  • Phytochemistry Medicinal Plant Applications
  • Natural product bioactivities and synthesis
  • Plant and animal studies
  • Phytochemicals and Antioxidant Activities
  • Natural Compound Pharmacology Studies
  • Plant biochemistry and biosynthesis
  • Phytochemical compounds biological activities
  • Insect and Pesticide Research
  • Bee Products Chemical Analysis
  • Plant Parasitism and Resistance
  • Chemical synthesis and alkaloids
  • Allelopathy and phytotoxic interactions
  • Bioactive Natural Diterpenoids Research
  • Plant Diversity and Evolution
  • Ethnobotanical and Medicinal Plants Studies
  • Insect-Plant Interactions and Control
  • Phytochemistry and Bioactivity Studies
  • Rural Development and Agriculture
  • Ruminant Nutrition and Digestive Physiology
  • Agricultural Science and Fertilization
  • Biological Stains and Phytochemicals

Universidade Federal de Sergipe
2016-2025

Universidade Federal do Ceará
1995-2012

Universidade Estadual de Campinas (UNICAMP)
1998-2001

Medicinal plants are one of the most important sources drugs used in pharmaceutical industry. Among traditional medicinal plants, Lippia gracilis Schauer (Verbenaceae) had been for several purposes Brazilian northeastern. In this study, leaf essential oil (EO) L. was prepared using hydrodistillation. Followed by GC–MS analysis, its composition characterized presence thymol (55.50%), as major constituent. The effects EO on cell proliferation and apoptosis induction were investigated HepG2...

10.1016/j.phymed.2013.01.015 article EN publisher-specific-oa Phytomedicine 2013-02-28

Abstract Introduction The species Lantana camara is used in folk medicine. biological activities of this medicinal plant are attributable to the presence various derivatives triterpenoids and phenolic compounds present its preparations, indicating excellent economic potential. Objective In study, operational conditions ultrasound‐assisted extraction (UAE) microwave‐assisted (MAE) were optimized using Box–Behnken design improve total content (TPC) recovered hydroethanolic extracts L. leaves....

10.1002/pca.3335 article EN Phytochemical Analysis 2024-02-18

Herbal drugs have been used since ancient times to treat a wide range of diseases. Morinda citrifolia Linn (popularly known as "Noni") has in folk medicine by Polynesians for over 2,000 years. It is reported broad therapeutic effects, including effects against headache, fever, arthritis, gingivitis, respiratory disorders, infections, tuberculosis, and diabetes. The aim this study was investigate the antioxidant, anti-inflammatory, antinociceptive, antibacterial properties aqueous extract...

10.1089/jmf.2010.0254 article EN Journal of Medicinal Food 2011-05-07

The antioxidant capacity by oxygen radical absorbance (ORAC)-FL method and antimicrobial activity using the broth microdilution of aporphinoids (liriodenine 1, anonaine 2 asimilobine 3) other alkaloids (reticuline 4 cleistopholine 5) isolated from bark Annona salzmannii A. DC. (Annonaceae) were evaluated. For activity, most active alkaloid was with ORAC value 2.09 relative trolox equivalents. some showed significant minimal inhibitory concentration (MIC) values in range 25-100 µg mL(-1)....

10.1080/14786419.2012.688044 article EN Natural Product Research 2012-05-15

The essential oils from the leaves of Annona salzmannii and A. pickelii (Annonaceae) growing in Sergipe, northeastern region Brazil, were obtained by hydrodistillation using a Clevenger-type apparatus, analyzed GC/MS GC/FID. Thirty-four compounds identified oil twenty-seven that pickelii; sesquiterpenes predominated both oils. Bicyclogermacrene (20.3%), ( E)-caryophyllene (19.9%), δ-cadinene (15.3%), α-copaene (10.0%), allo-aromadendrene (5.7%) main components salzmannii, bicyclogermacrene...

10.1177/1934578x1100600636 article EN Natural Product Communications 2011-06-01

Ruthenium-based compounds have gained great interest due to their potent cytotoxicity in cancer cells; however, much of potential applications remain unexplored. In this paper, we report the synthesis a novel ruthenium complex with xanthoxylin (RCX) and investigation its cellular molecular action human hepatocellular carcinoma HepG2 cells. We found that RCX exhibited cytotoxic effect panel cell lines monolayer cultures 3D model multicellular spheroids formed from This compound is detected at...

10.1038/s41419-017-0104-6 article EN cc-by Cell Death and Disease 2018-01-23

The production of Ocimum basilicum (basil) crop depends upon the availability all nutrients in soil solution. There is a lack information about its performance, at tropical conditions, using new fertilizer formulations, such as organo-mineral fertilizers, mainly under protected cultivation. These types fertilizers combine benefits main used agriculture (organic and chemical). Therefore, enhance health, provide balanced nutrient supply, improve yields quality. promote environmental...

10.3390/plants14070997 article EN cc-by Plants 2025-03-22

► Leaves of Annona pickelii yielded terpenes, lignans, and isoquinoline alkaloids. Isolated compounds are reported for the first time. Isoquinoline alkaloids chemotaxonomic marker genus . Furofuranic type lignans predominant in leaves A. The NMR data nornuciferine ( 8 ) were revised.

10.1016/j.bse.2011.12.011 article EN publisher-specific-oa Biochemical Systematics and Ecology 2012-01-14

The essential oil from the leaves of Annona vepretorun was obtained by hydrodistillation using a Clevenger-type apparatus and analyzed GC-MS GC-FID. Eighteen compounds representing 98.1% crude were identified. major identified bicyclogermacrene (43.7%), spathulenol (11.4%), alpha-felandrene (10.0%), alpha-pinene (7.1%), (E)-beta-ocimene (6.8%), germacrene D (5.8%), p-cymene (4.2%). trypanocidal activity against Trypanosoma cruzi epimastigote forms, as well as, antimicrobial antioxidant...

10.1177/1934578x1200700240 article EN Natural Product Communications 2012-02-01

► Bark of Annona salzmannii yielded sesquiterpenes, steroids, and isoquinoline alkaloids. Isoquinoline alkaloids are the chemotaxonomic marker genus . The NMR data for reticuline ( 12 ) were revised. Selin-11-en-4 α -ol 3 is reported first time in

10.1016/j.bse.2011.06.008 article EN publisher-specific-oa Biochemical Systematics and Ecology 2011-07-24

Caesalpinia pyramidalis Tul. (Fabaceae) is a plant found in the Northeast of Brazil that popularly used to treat inflammation. Acute pancreatitis (AP) an inflammatory disease for which abdominal pain relevant symptom. As there no specific therapy AP, we investigated effect ethanol extract from inner bark C. (EECp) on AP induced by common bile duct obstruction (CBDO) rats.AP was male Wistar rats (200-250 g, n=6-8) through laparotomy and subsequent CBDO. Animals were euthanized after 6 (G6h)...

10.1016/j.jep.2012.05.015 article EN publisher-specific-oa Journal of Ethnopharmacology 2012-05-22

Phytochemical investigation of the hexane extract from stem Xylopia laevigata led to isolation ent-kaurane diterpenoids, ent-kaur-16-en-19-oic acid, 4-epi-kaurenic ent-16β-hydroxy-17-acetoxy-kauran-19-al, ent-3β-hydroxy-kaur-16-en-19-oic and ent-16β,17-dihydroxy-kauran-19-oic as well spathulenol a mixture β-sitosterol, stigmasterol campesterol. The identification compounds was performed on basis spectrometric methods including GC-MS, IR, 1D 2D NMR. Potent larvicidal activity against Aedes...

10.1590/s0100-40422012000800015 article EN cc-by-nc Química Nova 2012-01-01

"Aspectos químicos e biológicos do gênero Lippia enfatizando gracilis Schauer". Esta revisão apresenta um estudo sobre os principais constituintes aspectos de espécies a Schauer. O Verbenaceae) possui aproximadamente 200 ervas, arbustos pequenas árvores, cujos maiores centros dispersão se encontram em países das Américas Sul Central, como também territórios da África tropical. Inúmeras são usadas na medicina popular para o tratamento resfriados, gripes, bronquites tosse. As pesquisas...

10.1590/s0100-46702011000100005 article PT cc-by Eclética Química 2011-01-01

Pelargonium graveolens l'Herit AND Lippia alba (Mill) N. E. Brown AGAINST Spodoptera frugiperda (J.E. Smith).Insecticidal activity of essential oils graveolens, and compounds geraniol, linalool, 1,8-cineole, limonene, carvone, citral Azamax ® were evaluated against frugiperda.Topical application assay showed oil P. has acute toxicity larvae (third instar) with LD 50 1.13 µg/mg per insect 90 2.56 insect.Three L. also exhibited insecticidal ranging from 1.20 to 1.56 2.60 3.75 insect.Geraniol,...

10.1590/s0100-40422013000900020 article EN cc-by-nc Química Nova 2013-01-01

Essential oils from leaves of Xylopia frutescens (XFMJ) and two specimens laevigata (XLMC XLSI) were obtained by hydrodistillation using a Clevenger-type apparatus, analyzed GC-MS GC-FID. Sesquiterpenes dominated the essential oils. The main constituents XFMJ (E)-caryophyllene (24.8%), bicyclogermacrene (20.8%), germacrene D (17.0%), beta-elemene (7.9%), (E)-beta-ocimene (6.8%). XLMC contained significant quantities (18.9%), (18.4%), (9.5%), delta-selinene (9.2%), (8.5%), B (5.7%)...

10.1177/1934578x1300800332 article EN Natural Product Communications 2013-03-01

The aim of this study was to evaluate the concentration and chemical composition essential oil leaves basil cultivars hybrids cultivated in different cropping seasons: dry season rainy season.The variables evaluated were content oils two seasons.The ranged from 0.66% 3.21% 0.80% 4.20% major compounds found among genotypes linalool, methyl chavicol, neral, geranial, eugenol, (E)cinnamate, defining formation five groups each season, classified following chemotypes: chavicol (Group 1), citral...

10.35588/blacpma.19.18.1.05 article EN Boletin Latinoamericano y del Caribe de plantas Medicinales y Aromaticas 2019-01-01
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