A5101809649- Ear Surgery and Otitis Media
- Facial Nerve Paralysis Treatment and Research
- Airway Management and Intubation Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Folate and B Vitamins Research
- Surgical Simulation and Training
- Genetics and Neurodevelopmental Disorders
- Ultrasound and Hyperthermia Applications
- Lysosomal Storage Disorders Research
- Medical Imaging and Analysis
- Antimicrobial Peptides and Activities
- Genomic variations and chromosomal abnormalities
- Bipolar Disorder and Treatment
- Ear and Head Tumors
- Porphyrin Metabolism and Disorders
- RNA modifications and cancer
- Ion Transport and Channel Regulation
- RNA regulation and disease
- Voice and Speech Disorders
- Infrared Thermography in Medicine
- Health, Environment, Cognitive Aging
- Thyroid and Parathyroid Surgery
- Foreign Body Medical Cases
- Technology and Human Factors in Education and Health
McGill University Health Centre
2000-2024
Jewish General Hospital
2022-2024
McGill University
2003-2024
Western University
2013-2019
University of Toronto
2011-2017
Hospital for Sick Children
2015-2017
SickKids Foundation
2017
McGill Genome Centre
2001-2006
University of Calgary
2002
Vitamin B 12 (cobalamin) is an essential cofactor of two enzymes, methionine synthase and methylmalonyl-CoA mutase. The conversion the vitamin to its coenzymes requires a series biochemical modifications for which several genetic diseases are known, comprising eight complementation groups ( cblA through cblH ). objective this study was clone gene responsible group thought represent mitochondrial cobalamin reductase. Examination bacterial operons containing genes in close proximity mutase...
Proper understanding of the roles of, and interactions between genetic, lifestyle, environmental psycho-social factors in determining risk development and/or progression chronic diseases requires access to very large high-quality databases. Because financial, technical time burdens related developing maintaining studies, scientific community is increasingly synthesizing data from multiple studies construct However, items collected by individual must be inferentially equivalent meaningfully...
Glutamate formiminotransferase deficiency, an autosomal recessive disorder and the second most common inborn error of folate metabolism, is presumed to be due defects in bifunctional enzyme glutamate formiminotransferase-cyclodeaminase (FTCD). Features a severe phenotype, first identified patients Japanese descent, include elevated levels formiminoglutamate (FIGLU) urine response histidine administration, megaloblastic anemia, mental retardation. mild phenotype high urinary excretion FIGLU...
The primary objective of this study was to use high-resolution micro-CT images create accurate three-dimensional (3D) models several intratemporal structures, and compare surgically important dimensions within the temporal bone. secondary a statistical shape model (SSM) dominant non-dominant sigmoid sinus (SS) provide template for automated segmentation algorithms.A free image processing software, 3D Slicer, utilized reconstructions SS, jugular bulb (JB), facial nerve (FN), external auditory...
ABSTRACT Candida albicans is an opportunistic human pathogen causing both superficial and disseminated diseases. It a dimorphic fungus, switching between yeast hyphal forms, depending on cues from its microenvironment. Hyphae play important role in the pathogenesis of candidiasis. The host's response to infection multifaceted includes participation granulocytes as key effector cells. aim this investigation was study host gene expression during granulocyte- interaction. Effector cells were...
Purpose Magnetic resonance‐guided focused ultrasound ( MR g FUS ) is emerging as a treatment alternative for osteoid osteoma and painful bone metastases. This study describes new simulation platform that predicts the distribution of heat generated by when applied to tissue. Methods Calculation temperature was performed using two mathematical models. The first determined propagation absorption acoustic energy through each medium, this multilayered approximation Rayleigh integral method....
Hypothesis: To characterize anatomical measurements and shape variation of the facial nerve within temporal bone, to create statistical models (SSMs) enhance knowledge bone anatomy aid in automated segmentation. Background: The is a fundamental structure otologic surgery, detailed anatomic with surgical experience are needed avoid its iatrogenic injury. Trainees can use simulators practice techniques, however manual segmentation required develop simulations be time consuming. Consequently,...
Purpose: This paper presents the design of a micro‐CT guided small animal robotic needle positioning system. In order to simplify and maintain targeting error, novel implementation remote center motion is used in The system has been developed with objective achieving mean error <200 μm while maintaining high degree user friendliness. Methods: robot compact enough operate within 25 cm diameter bore. Small animals can be imaged an intervention performed without need transport from one...
Background Obstructive upper airway pathologies are a great clinical challenge for the surgeon. Protection against acute obstruction is critical, but avoidance of unnecessary tracheostomy must also be considered. Decision‐making regarding airway, although supported by some objective findings, largely guided subjective experience and training. This investigation aims to study relationship between respiratory distress measures resistance in laryngeal cancer as determined computational fluid...
Abstract Hypersensitivity to bloodworms (chironomid larvae) leading asthma and other related allergic disorders is becoming common in individuals who keep or work with fish due the increased use of as food bait.
To help improve therapeutic results for treatment of bone tumors, high intensity focused ultrasound (HIFU) is being investigated as a non-invasive alternative to surgery and radiotherapy. HIFU ablative treatments require an imaging modality guidance, magnetic resonance (MR) currently the strongest choice it able provide temperature mapping throughout process. Unfortunately, feedback that critical ensuring safety optimal soft tissue ablation often unobtainable in structures. As obtaining...
A healthy teenager presented to the emergency department with high-grade fever, neck pain, and a foreign body sensation in throat after eating chicken 3 days prior. What is your diagnosis?
Abstract Background The American Thyroid Association supports same-day thyroid surgery (SDT) in select patients. In practice, it is common for surgeons to monitor patients overnight postoperative complications such as cervical hematoma, recurrent laryngeal nerve injury (RLN) and symptomatic hypocalcemia. We sought determine the safety profile predictive factors of adverse outcomes SDT based on experience three large institutions. Methods A retrospective cohort study was conducted all...
Lattice defects in crystalline materials create long-range elastic fields which can be modelled on the atomistic scale using an infinite system of discrete nonlinear force balance equations. Starting with these equations, this work rigorously derives a novel far-field expansion fields: The is computable and expressed as sum continuum correctors multipole terms decay increasing algebraic rate order increases. Truncating leaves remainder describing defect core structure, localised sense that...